Ангіотензиноген

Ангіотензиноген (англ. Angiotensinogen) – білок, який кодується геном AGT, розташованим у людей на короткому плечі першої хромосоми[3]. Довжина поліпептидного ланцюга білка становить 485 амінокислот, а молекулярна маса — 53 154[4].

Ангіотензиноген
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 2WXW, 2X0B, 4APH,%%s1N9U, 1N9V,%%s1N9V, 1N9U, 3CK0, 4AA1, 4APH, 5E2Q
Ідентифікатори
Символи	AGT, ANHU, SERPINA8, hFLT1, angiotensinogen
Зовнішні ІД	MGI: 87963 HomoloGene: 14 GeneCards: AGT
Онтологія гена Молекулярна функція • GO:0001948 protein binding • serine-type endopeptidase inhibitor activity • type 1 angiotensin receptor binding • hormone activity • superoxide-generating NADPH oxidase activator activity • growth factor activity • type 2 angiotensin receptor binding • sodium channel regulator activity • angiotensin receptor binding • receptor ligand activity Клітинна компонента • цитоплазма • Екзосома • blood microparticle • extracellular space • гіалоплазма • extracellular region • collagen-containing extracellular matrix Біологічний процес • uterine smooth muscle contraction • renal system process • vasoconstriction • GO:0048554 positive regulation of catalytic activity • positive regulation of cardiac muscle hypertrophy • cell surface receptor signaling pathway • cellular response to mechanical stimulus • stress-activated MAPK cascade • artery smooth muscle contraction • regulation of systemic arterial blood pressure by renin-angiotensin • regulation of apoptotic process • negative regulation of neurotrophin TRK receptor signaling pathway • regulation of long-term neuronal synaptic plasticity • positive regulation of renal sodium excretion • positive regulation of fibroblast proliferation • cellular sodium ion homeostasis • ERK1 and ERK2 cascade • activation of phospholipase C activity • angiotensin maturation • positive regulation of extracellular matrix constituent secretion • positive regulation of blood pressure • negative regulation of cell growth • regulation of norepinephrine secretion • female pregnancy • negative regulation of tissue remodeling • regulation of heart rate • smooth muscle cell proliferation • regulation of calcium ion transport • regulation of transmission of nerve impulse • cell growth involved in cardiac muscle cell development • response to muscle activity involved in regulation of muscle adaptation • positive regulation of nitric oxide biosynthetic process • angiotensin-mediated drinking behavior • cell-cell signaling • старіння людини • vasodilation • positive regulation of cell population proliferation • fibroblast proliferation • negative regulation of angiogenesis • positive regulation of superoxide anion generation • positive regulation of L-lysine import across plasma membrane • positive regulation of cardiac muscle cell apoptotic process • positive regulation of vascular associated smooth muscle cell proliferation • positive regulation of cytosolic calcium ion concentration • negative regulation of endopeptidase activity • positive regulation of vascular associated smooth muscle cell migration • regulation of molecular function • regulation of lipid metabolic process • positive regulation of L-arginine import across plasma membrane • regulation of signaling receptor activity • positive regulation of neuron projection development • response to estradiol • cellular response to angiotensin • protein import into nucleus • associative learning • Оперантне обумовлення • positive regulation of insulin receptor signaling pathway • regulation of extracellular matrix assembly • positive regulation of cholesterol esterification • phospholipase C-activating G protein-coupled receptor signaling pathway • blood vessel remodeling • positive regulation of reactive oxygen species metabolic process • positive regulation of extrinsic apoptotic signaling pathway • positive regulation of cellular protein metabolic process • positive regulation of branching involved in ureteric bud morphogenesis • kidney development • positive regulation of transcription, DNA-templated • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of inflammatory response • positive regulation of protein tyrosine kinase activity • regulation of blood pressure • positive regulation of macrophage derived foam cell differentiation • regulation of vasoconstriction • positive regulation of NF-kappaB transcription factor activity • positive regulation of NAD(P)H oxidase activity • nitric oxide mediated signal transduction • G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger • positive regulation of epidermal growth factor receptor signaling pathway • regulation of blood volume by renin-angiotensin • regulation of cardiac conduction • maintenance of blood vessel diameter homeostasis by renin-angiotensin • regulation of renal sodium excretion • positive regulation of cytokine production • positive regulation of membrane hyperpolarization • negative regulation of sodium ion transmembrane transporter activity • renin-angiotensin regulation of aldosterone production • positive regulation of endothelial cell migration • low-density lipoprotein particle remodeling • regulation of cell population proliferation • regulation of cell growth • positive regulation of gap junction assembly • positive regulation of phosphatidylinositol 3-kinase signaling • angiotensin-activated signaling pathway • negative regulation of gene expression • regulation of renal output by angiotensin • positive regulation of activation of Janus kinase activity • G protein-coupled receptor signaling pathway Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	183	11606
Ensembl	ENSG00000135744	ENSMUSG00000031980
UniProt	P01019	P11859 Q3UTR7
RefSeq (мРНК)	NM_000029 NM_001382817 NM_001384479	NM_007428
RefSeq (білок)	NP_000020 NP_001369746	NP_031454
Локус (UCSC)	Хр. 1: 230.69 – 230.75 Mb	Хр. 8: 124.56 – 124.57 Mb
PubMed search	[1]	[2]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Цей білок за функціями належить до вазоактивних білків, вазоконстрикторів (має судинозвужуючий ефект). Регулятор артеріального тиску та водно-сольового обміну організму. Секретований назовні.