LYST
LYST (англ. Lysosomal trafficking regulator) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. [4] Довжина поліпептидного ланцюга білка становить 3 801 амінокислот, а молекулярна маса — 429 139[5].
Послідовність амінокислот
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSTDSNSLAR | EFLTDVNRLC | NAVVQRVEAR | EEEEEETHMA | TLGQYLVHGR | ||||
| GFLLLTKLNS | IIDQALTCRE | ELLTLLLSLL | PLVWKIPVQE | EKATDFNLPL | ||||
| SADIILTKEK | NSSSQRSTQE | KLHLEGSALS | SQVSAKVNVF | RKSRRQRKIT | ||||
| HRYSVRDARK | TQLSTSDSEA | NSDEKGIAMN | KHRRPHLLHH | FLTSFPKQDH | ||||
| PKAKLDRLAT | KEQTPPDAMA | LENSREIIPR | QGSNTDILSE | PAALSVISNM | ||||
| NNSPFDLCHV | LLSLLEKVCK | FDVTLNHNSP | LAASVVPTLT | EFLAGFGDCC | ||||
| SLSDNLESRV | VSAGWTEEPV | ALIQRMLFRT | VLHLLSVDVS | TAEMMPENLR | ||||
| KNLTELLRAA | LKIRICLEKQ | PDPFAPRQKK | TLQEVQEDFV | FSKYRHRALL | ||||
| LPELLEGVLQ | ILICCLQSAA | SNPFYFSQAM | DLVQEFIQHH | GFNLFETAVL | ||||
| QMEWLVLRDG | VPPEASEHLK | ALINSVMKIM | STVKKVKSEQ | LHHSMCTRKR | ||||
| HRRCEYSHFM | HHHRDLSGLL | VSAFKNQVSK | NPFEETADGD | VYYPERCCCI | ||||
| AVCAHQCLRL | LQQASLSSTC | VQILSGVHNI | GICCCMDPKS | VIIPLLHAFK | ||||
| LPALKNFQQH | ILNILNKLIL | DQLGGAEISP | KIKKAACNIC | TVDSDQLAQL | ||||
| EETLQGNLCD | AELSSSLSSP | SYRFQGILPS | SGSEDLLWKW | DALKAYQNFV | ||||
| FEEDRLHSIQ | IANHICNLIQ | KGNIVVQWKL | YNYIFNPVLQ | RGVELAHHCQ | ||||
| HLSVTSAQSH | VCSHHNQCLP | QDVLQIYVKT | LPILLKSRVI | RDLFLSCNGV | ||||
| SQIIELNCLN | GIRSHSLKAF | ETLIISLGEQ | QKDASVPDID | GIDIEQKELS | ||||
| SVHVGTSFHH | QQAYSDSPQS | LSKFYAGLKE | AYPKRRKTVN | QDVHINTINL | ||||
| FLCVAFLCVS | KEAESDRESA | NDSEDTSGYD | STASEPLSHM | LPCISLESLV | ||||
| LPSPEHMHQA | ADIWSMCRWI | YMLSSVFQKQ | FYRLGGFRVC | HKLIFMIIQK | ||||
| LFRSHKEEQG | KKEGDTSVNE | NQDLNRISQP | KRTMKEDLLS | LAIKSDPIPS | ||||
| ELGSLKKSAD | SLGKLELQHI | SSINVEEVSA | TEAAPEEAKL | FTSQESETSL | ||||
| QSIRLLEALL | AICLHGARTS | QQKMELELPN | QNLSVESILF | EMRDHLSQSK | ||||
| VIETQLAKPL | FDALLRVALG | NYSADFEHND | AMTEKSHQSA | EELSSQPGDF | ||||
| SEEAEDSQCC | SFKLLVEEEG | YEADSESNPE | DGETQDDGVD | LKSETEGFSA | ||||
| SSSPNDLLEN | LTQGEIIYPE | ICMLELNLLS | ASKAKLDVLA | HVFESFLKII | ||||
| RQKEKNVFLL | MQQGTVKNLL | GGFLSILTQD | DSDFQACQRV | LVDLLVSLMS | ||||
| SRTCSEELTL | LLRIFLEKSP | CTKILLLGIL | KIIESDTTMS | PSQYLTFPLL | ||||
| HAPNLSNGVS | SQKYPGILNS | KAMGLLRRAR | VSRSKKEADR | ESFPHRLLSS | ||||
| WHIAPVHLPL | LGQNCWPHLS | EGFSVSLWFN | VECIHEAEST | TEKGKKIKKR | ||||
| NKSLILPDSS | FDGTESDRPE | GAEYINPGER | LIEEGCIHII | SLGSKALMIQ | ||||
| VWADPHNATL | IFRVCMDSND | DMKAVLLAQV | ESQENIFLPS | KWQHLVLTYL | ||||
| QQPQGKRRIH | GKISIWVSGQ | RKPDVTLDFM | LPRKTSLSSD | SNKTFCMIGH | ||||
| CLSSQEEFLQ | LAGKWDLGNL | LLFNGAKVGS | QEAFYLYACG | PNHTSVMPCK | ||||
| YGKPVNDYSK | YINKEILRCE | QIRELFMTKK | DVDIGLLIES | LSVVYTTYCP | ||||
| AQYTIYEPVI | RLKGQMKTQL | SQRPFSSKEV | QSILLEPHHL | KNLQPTEYKT | ||||
| IQGILHEIGG | TGIFVFLFAR | VVELSSCEET | QALALRVILS | LIKYNQQRVH | ||||
| ELENCNGLSM | IHQVLIKQKC | IVGFYILKTL | LEGCCGEDII | YMNENGEFKL | ||||
| DVDSNAIIQD | VKLLEELLLD | WKIWSKAEQG | VWETLLAALE | VLIRADHHQQ | ||||
| MFNIKQLLKA | QVVHHFLLTC | QVLQEYKEGQ | LTPMPREVCR | SFVKIIAEVL | ||||
| GSPPDLELLT | IIFNFLLAVH | PPTNTYVCHN | PTNFYFSLHI | DGKIFQEKVR | ||||
| SIMYLRHSSS | GGRSLMSPGF | MVISPSGFTA | SPYEGENSSN | IIPQQMAAHM | ||||
| LRSRSLPAFP | TSSLLTQSQK | LTGSLGCSID | RLQNIADTYV | ATQSKKQNSL | ||||
| GSSDTLKKGK | EDAFISSCES | AKTVCEMEAV | LSAQVSVSDV | PKGVLGFPVV | ||||
| KADHKQLGAE | PRSEDDSPGD | ESCPRRPDYL | KGLASFQRSH | STIASLGLAF | ||||
| PSQNGSAAVG | RWPSLVDRNT | DDWENFAYSL | GYEPNYNRTA | SAHSVTEDCL | ||||
| VPICCGLYEL | LSGVLLILPD | VLLEDVMDKL | IQADTLLVLV | NHPSPAIQQG | ||||
| VIKLLDAYFA | RASKEQKDKF | LKNRGFSLLA | NQLYLHRGTQ | ELLECFIEMF | ||||
| FGRHIGLDEE | FDLEDVRNMG | LFQKWSVIPI | LGLIETSLYD | NILLHNALLL | ||||
| LLQILNSCSK | VADMLLDNGL | LYVLCNTVAA | LNGLEKNIPM | SEYKLLACDI | ||||
| QQLFIAVTIH | ACSSSGSQYF | RVIEDLIVML | GYLQNSKNKR | TQNMAVALQL | ||||
| RVLQAAMEFI | RTTANHDSEN | LTDSLQSPSA | PHHAVVQKRK | SIAGPRKFPL | ||||
| AQTESLLMKM | RSVANDELHV | MMQRRMSQEN | PSQATETELA | QRLQRLTVLA | ||||
| VNRIIYQEFN | SDIIDILRTP | ENVTQSKTSV | FQTEISEENI | HHEQSSVFNP | ||||
| FQKEIFTYLV | EGFKVSIGSS | KASGSKQQWT | KILWSCKETF | RMQLGRLLVH | ||||
| ILSPAHAAQE | RKQIFEIVHE | PNHQEILRDC | LSPSLQHGAK | LVLYLSELIH | ||||
| NHQGELTEEE | LGTAELLMNA | LKLCGHKCIP | PSASTKADLI | KMIKEEQKKY | ||||
| ETEEGVNKAA | WQKTVNNNQQ | SLFQRLDSKS | KDISKIAADI | TQAVSLSQGN | ||||
| ERKKVIQHIR | GMYKVDLSAS | RHWQELIQQL | THDRAVWYDP | IYYPTSWQLD | ||||
| PTEGPNRERR | RLQRCYLTIP | NKYLLRDRQK | SEDVVKPPLS | YLFEDKTHSS | ||||
| FSSTVKDKAA | SESIRVNRRC | ISVAPSRETA | GELLLGKCGM | YFVEDNASDT | ||||
| VESSSLQGEL | EPASFSWTYE | EIKEVHKRWW | QLRDNAVEIF | LTNGRTLLLA | ||||
| FDNTKVRDDV | YHNILTNNLP | NLLEYGNITA | LTNLWYTGQI | TNFEYLTHLN | ||||
| KHAGRSFNDL | MQYPVFPFIL | ADYVSETLDL | NDLLIYRNLS | KPIAVQYKEK | ||||
| EDRYVDTYKY | LEEEYRKGAR | EDDPMPPVQP | YHYGSHYSNS | GTVLHFLVRM | ||||
| PPFTKMFLAY | QDQSFDIPDR | TFHSTNTTWR | LSSFESMTDV | KELIPEFFYL | ||||
| PEFLVNREGF | DFGVRQNGER | VNHVNLPPWA | RNDPRLFILI | HRQALESDYV | ||||
| SQNICQWIDL | VFGYKQKGKA | SVQAINVFHP | ATYFGMDVSA | VEDPVQRRAL | ||||
| ETMIKTYGQT | PRQLFHMAHV | SRPGAKLNIE | GELPAAVGLL | VQFAFRETRE | ||||
| QVKEITYPSP | LSWIKGLKWG | EYVGSPSAPV | PVVCFSQPHG | ERFGSLQALP | ||||
| TRAICGLSRN | FCLLMTYSKE | QGVRSMNSTD | IQWSAILSWG | YADNILRLKS | ||||
| KQSEPPVNFI | QSSQQYQVTS | CAWVPDSCQL | FTGSKCGVIT | AYTNRFTSST | ||||
| PSEIEMETQI | HLYGHTEEIT | SLFVCKPYSI | LISVSRDGTC | IIWDLNRLCY | ||||
| VQSLAGHKSP | VTAVSASETS | GDIATVCDSA | GGGSDLRLWT | VNGDLVGHVH | ||||
| CREIICSVAF | SNQPEGVSIN | VIAGGLENGI | VRLWSTWDLK | PVREITFPKS | ||||
| NKPIISLTFS | CDGHHLYTAN | SDGTVIAWCR | KDQQRLKQPM | FYSFLSSYAA | ||||
| G |
Задіяний у таких біологічних процесах як транспорт, транспорт білків. Локалізований у цитоплазмі.
Література
- Hillman R.T., Green R.E., Brenner S.E. (2004). An unappreciated role for RNA surveillance.. Genome Biol. 5: R8.1 — R8.16. PubMed DOI:10.1186/gb-2004-5-2-r8
Примітки
- Захворювання, генетично пов'язані з LYST переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:1968 (англ.). Процитовано 25 серпня 2017.
- UniProt, Q99698 (англ.). Процитовано 25 серпня 2017.
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