SZT2
SZT2 (англ. SZT2, KICSTOR complex subunit) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. [3] Довжина поліпептидного ланцюга білка становить 3 432 амінокислот, а молекулярна маса — 378 029[4].
Послідовність амінокислот
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MASERPEPEV | EEAGQVFLLM | KKDYRISRNV | RLAWFLSHLH | QTVQATPQEM | ||||
| LLQSEQELEV | LSVLPPGWQP | DEPVVPRPFL | LVPSTRVTFL | AWQYRFVIEL | ||||
| DLSPSTGIVD | DSTGEILFDE | VFHALSRCLG | GLLRPFRVPG | SCIDFQPEIY | ||||
| VTIQAYSSII | GLQSHQVLVQ | GCLLDPSQRE | VFLQQIYEQL | CLFEDKVATM | ||||
| LQQQYDPQSQ | AEDQSPDSGD | LLGRKVGVSM | VTADLGLVSM | IRQGILALQL | ||||
| LPSNSSAGII | VITDGVTSVP | DVAVCETLLN | QLRSGTVACS | FVQVGGVYSY | ||||
| DCSFGHVPNV | ELMKFIAMAT | FGSYLSTCPE | PEPGNLGLTV | YHRAFLLYSF | ||||
| LRSGEALNPE | YYCGSQHRLF | NEHLVSASSN | PALALRRKKH | TEKEVPADLV | ||||
| STVSVRLREG | YSVREVTLAK | GGSQLEVKLV | LLWKHNMRIE | YVAMAPWPLE | ||||
| PEGPRVTRVE | VTMEGGYDIL | HDVSCALRQP | IRSLYRTHVI | RRFWNTLQSI | ||||
| NQTDQMLAHL | QSFSSVPEHF | TLPDSTKSGV | PLFYIPPGST | TPVLSLQPSG | ||||
| SDSSHAQFAA | YWKPVLSMDA | NSWQRWLHMH | RLVLILEHDT | PIPKHLHTPG | ||||
| SNGRYSTIQC | RISHSSLTSL | LRDWSSFVLV | EGYSYVKLLS | SAPDQPPNSF | ||||
| YMVRIISKAP | CMVLRLGFPI | GTPAPARHKI | VSGLREEILR | LRFPHRVQSK | ||||
| EPTPKVKRKG | LGGAGGGSSP | SKSPPVLGPQ | QALSDRPCLV | VLHKPLDKLL | ||||
| IRYEKLPLDY | RAPFLLTLEP | PGPLPLVSGR | SASSSLASLS | RYLYHQRWLW | ||||
| SVPSGLAPAL | PLSAIAQLLS | ILTEVRLSEG | FHFACSGEGI | INMVLELPIQ | ||||
| NEPPGQAAAE | EKHTCVVQYI | LFPPHSTSTK | DSFSTDDDND | VEVEALEGDS | ||||
| ELNLVTEVWV | EPQYGRVGPG | PGIWKHLQDL | TYSEIPQALH | PRDAACIGSM | ||||
| LSFEYLIQLC | QSKEWGPLPP | EPRVSDGLDQ | GGDTCVHEIP | FHFDLMGLLP | ||||
| QCQQLQMFFL | LLAREPEGVP | FAEGSCPAND | MVLCLLHSCL | GQELSDREIP | ||||
| LTPVDQAAFL | SEVLRRTCHV | PGAEGPLLGV | HGIPKEQAVG | STQATGDSAF | ||||
| TSLSVGLPET | LKPLISAQPP | QWRCYARLVN | PQHVFLTFLP | ATFSDVQRLA | ||||
| ACGLEGPPQE | ETKPKFGDWS | GAPSLKDLGG | TGIKATKSHV | PVLSVTLASD | ||||
| NAQNQGELSP | PFRRDLQAYA | GRQASQTESA | DGPRTRCPVY | IYSCSLEALR | ||||
| EQMVGMQPPQ | APRDLIFRTQ | FLDHPSPSSA | WMEPRYKEAA | NHCALLQEHA | ||||
| QRCYVRGLFR | SLQQAQSVTS | QDLLTAVDAC | EELLQEIDIT | PFLLALCGHT | ||||
| WGLPHAPPSP | GPLSPGPFSS | SMEEGAEPRE | RAILASESSI | ETEDLSEPEF | ||||
| QSTRVPGIPD | PGPEISLTDV | CQLRGEAHGA | LHSVIQEKFL | EISRLHFRTV | ||||
| PSNPHYFFYC | PPSSRREDEG | PRDTVDRKIS | DLEFSEAELM | GEEGDTSACC | ||||
| VVTESDPELE | VEYRESRESD | LGPAGLDSAS | LSDVDTVNPD | EDSFSILGGD | ||||
| SPTGPESFLH | DLPPLFLHLT | CSVRLRGQHS | SVPVCSLPTC | LGQVLSSLEG | ||||
| PPVGGRVPLR | DLSVTLDVFM | LTLPLEVELP | TASDPQHHRS | TSESSASFPR | ||||
| SPGQPSSLRS | DDGLGPPLPP | PEEERHPGLS | NLATPHRLAI | ETTMNEIRWL | ||||
| LEDEMVGALR | RGGIPQSPAL | HRAAAHIHSS | PGRSTCLRQT | LPLSFVFGPE | ||||
| RSLTQFKEEF | RRLHLPGHVL | LEDPDSGFFF | VAAGQQPGGS | HGEPSSAAWA | ||||
| WHSHEDRAEG | IEGETLTASP | QAPGSPEDSE | GVPLISLPRV | PQGGSQPGPS | ||||
| RGLSLMSSQG | SVDSDHLGYD | GGSSGSDSEG | PNDTLGEKAP | FTLRTPPGPA | ||||
| PPQPSLSGLP | GPCLPDFWLI | VRVLQDRVEV | YAHARSLIRE | DGGPGTECRH | ||||
| LQQLLVRRVG | EICREVNQRL | LLQDLHDSHV | CNSLLVAESE | EDLWRSETPF | ||||
| HSRQRAPLPS | DDYAADESCA | PRGYLAATMQ | FVPGHFSCDV | VWGTVIRVHS | ||||
| RLKMGPSMGV | SRAIQALRSV | LNAFSVVNRK | NMFVYQERAT | KAVYYLRLLE | ||||
| TSCSDRPWKG | DALPPSLALS | RSQEPIYSEE | ASGPRSPLDM | VSSRSSDAAR | ||||
| PVGQVDRHIQ | LLVHGVGQAG | PEITDELVRV | LCRRLDEATL | DVITVMLVRN | ||||
| CKLTPADVEF | IQPPGSLPSE | VLHLALPTSC | RPWLPALAWY | LRQNLLIFLH | ||||
| SPKYTDSNSR | NHFQHPLPPQ | GGLPDLDIYL | YNKPGGQGTG | GKGVACITLA | ||||
| FVDEGGAPLS | LALWPPSSPG | PPDPLREEEF | EQLTQVIRCP | VVVDSSSAQN | ||||
| GAPRLRLDVW | EKGNISIVQL | EEKLRGAARQ | ALADAIIELQ | LLPASLCTED | ||||
| TPTGSLRNGS | LETKSSAGRA | STFPPAPVPG | EPVTPPSKAG | RRSFWDMLSK | ||||
| TECGDLGSPK | TTDDIVLDRP | EDTRGRRRHK | TESVRTPGGA | ERAPGSDSGA | ||||
| QRQKRRTTQL | EEGEVGTLHP | VFARVAQRWM | EFMVQIGCAS | VSRSSAHMVS | ||||
| RFLLPSILSE | FTALVTSMAG | DTSVRIFEQH | LGSEPEIFGP | CSPGQLGPSP | ||||
| RPAAERHLLL | LGRNFLQWRR | PTQQAAKAMQ | RFEPGGDGSS | GRNAPRQRLL | ||||
| LLEVVDKKLQ | LLTYNWAPDL | GAALGRALVR | LVQWQNARAH | LIFCLLSQKL | ||||
| GLFHHYGQLD | FPVRDEKEPN | PFLLPTMEVE | TLIRSASPPL | SREQGRLSGS | ||||
| SRGGGPLPLD | TFPFDEALRD | ITAARPSSVL | GPVPRPPDPV | TYHGQQFLEI | ||||
| KMAERRELER | QMKMENLFVT | WQQRSTPATM | PISAGELETL | KQSSRLVHYC | ||||
| ATAMLFDPAA | WLHGPPETSG | PPDGQRRHRP | ESGSGSREAP | TSCESLDVSP | ||||
| PGAREEPWLK | ELSLAFLQQY | VQYLQSIGFV | LVPLRPPSPA | RSTSRPRAMA | ||||
| ILGTEGRGSF | SCPKTKTDGS | PKSTSSPVTT | YHLQRALPGG | IILMELAFQG | ||||
| CYFCVKQFAL | ECSRIPMGQA | VNSQLSMLFT | EECDKVRDLM | HVHSFSYDFH | ||||
| LRLVHQHVLG | AHLVLRHGYH | LTTFLRHFLA | HHPDGPHFGR | NHIYQGTLEL | ||||
| PTPLIAAHQL | YNYVADHASS | YHMKPLRMAR | PGGPEHNEYA | LVSAWHSSGS | ||||
| YLDSEGLRHQ | DDFDVSLLVC | HCAAPFEEQG | EAERHVLRLQ | FFVVLTSQRE | ||||
| LFPRLTADMR | RFRKPPRLPP | EPEAPGSSAG | SPGEASGLIL | APGPAPLFPP | ||||
| LAAEVGMARA | RLAQLVRLAG | GHCRRDTLWK | RLFLLEPPGP | DRLRLGGRLA | ||||
| LAELEELLEA | VHAKSIGDID | PQLDCFLSMT | VSWYQSLIKV | LLSRFPQSCR | ||||
| HFQSPDLGTQ | YLVVLNQKFT | DCFVLVFLDS | HLGKTSLTVV | FREPFPVQPQ | ||||
| DSESPPAQLV | STYHHLESVI | NTACFTLWTR | LL |
Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у такому біологічному процесі як альтернативний сплайсинг. Локалізований у мембрані, лізосомі, пероксисомах.
Література
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14: 2121 — 2127. 2004. PubMed DOI:10.1101/gr.2596504
- Peng M., Yin N., Li M.O. (2017). SZT2 dictates GATOR control of mTORC1 signalling.. Nature 543: 433 — 437. PubMed DOI:10.1038/nature21378
Примітки
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:29040 (англ.). Процитовано 28 серпня 2017.
- UniProt, Q5T011 (англ.). Процитовано 28 серпня 2017.
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