Муцин-2
Муцин-2 (англ. Mucin 2, oligomeric mucus/gel-forming) – білок, який кодується геном MUC2, розташованим у людей на короткому плечі 11-ї хромосоми.[4] Довжина поліпептидного ланцюга білка становить 5 179 амінокислот, а молекулярна маса — 540 300[5].
Послідовність амінокислот
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MGLPLARLAA | VCLALSLAGG | SELQTEGRTR | YHGRNVCSTW | GNFHYKTFDG | ||||
| DVFRFPGLCD | YNFASDCRGS | YKEFAVHLKR | GPGQAEAPAG | VESILLTIKD | ||||
| DTIYLTRHLA | VLNGAVVSTP | HYSPGLLIEK | SDAYTKVYSR | AGLTLMWNRE | ||||
| DALMLELDTK | FRNHTCGLCG | DYNGLQSYSE | FLSDGVLFSP | LEFGNMQKIN | ||||
| QPDVVCEDPE | EEVAPASCSE | HRAECERLLT | AEAFADCQDL | VPLEPYLRAC | ||||
| QQDRCRCPGG | DTCVCSTVAE | FSRQCSHAGG | RPGNWRTATL | CPKTCPGNLV | ||||
| YLESGSPCMD | TCSHLEVSSL | CEEHRMDGCF | CPEGTVYDDI | GDSGCVPVSQ | ||||
| CHCRLHGHLY | TPGQEITNDC | EQCVCNAGRW | VCKDLPCPGT | CALEGGSHIT | ||||
| TFDGKTYTFH | GDCYYVLAKG | DHNDSYALLG | ELAPCGSTDK | QTCLKTVVLL | ||||
| ADKKKNAVVF | KSDGSVLLNQ | LQVNLPHVTA | SFSVFRPSSY | HIMVSMAIGV | ||||
| RLQVQLAPVM | QLFVTLDQAS | QGQVQGLCGN | FNGLEGDDFK | TASGLVEATG | ||||
| AGFANTWKAQ | STCHDKLDWL | DDPCSLNIES | ANYAEHWCSL | LKKTETPFGR | ||||
| CHSAVDPAEY | YKRCKYDTCN | CQNNEDCLCA | ALSSYARACT | AKGVMLWGWR | ||||
| EHVCNKDVGS | CPNSQVFLYN | LTTCQQTCRS | LSEADSHCLE | GFAPVDGCGC | ||||
| PDHTFLDEKG | RCVPLAKCSC | YHRGLYLEAG | DVVVRQEERC | VCRDGRLHCR | ||||
| QIRLIGQSCT | APKIHMDCSN | LTALATSKPR | ALSCQTLAAG | YYHTECVSGC | ||||
| VCPDGLMDDG | RGGCVVEKEC | PCVHNNDLYS | SGAKIKVDCN | TCTCKRGRWV | ||||
| CTQAVCHGTC | SIYGSGHYIT | FDGKYYDFDG | HCSYVAVQDY | CGQNSSLGSF | ||||
| SIITENVPCG | TTGVTCSKAI | KIFMGRTELK | LEDKHRVVIQ | RDEGHHVAYT | ||||
| TREVGQYLVV | ESSTGIIVIW | DKRTTVFIKL | APSYKGTVCG | LCGNFDHRSN | ||||
| NDFTTRDHMV | VSSELDFGNS | WKEAPTCPDV | STNPEPCSLN | PHRRSWAEKQ | ||||
| CSILKSSVFS | ICHSKVDPKP | FYEACVHDSC | SCDTGGDCEC | FCSAVASYAQ | ||||
| ECTKEGACVF | WRTPDLCPIF | CDYYNPPHEC | EWHYEPCGNR | SFETCRTING | ||||
| IHSNISVSYL | EGCYPRCPKD | RPIYEEDLKK | CVTADKCGCY | VEDTHYPPGA | ||||
| SVPTEETCKS | CVCTNSSQVV | CRPEEGKILN | QTQDGAFCYW | EICGPNGTVE | ||||
| KHFNICSITT | RPSTLTTFTT | ITLPTTPTSF | TTTTTTTTPT | SSTVLSTTPK | ||||
| LCCLWSDWIN | EDHPSSGSDD | GDREPFDGVC | GAPEDIECRS | VKDPHLSLEQ | ||||
| HGQKVQCDVS | VGFICKNEDQ | FGNGPFGLCY | DYKIRVNCCW | PMDKCITTPS | ||||
| PPTTTPSPPP | TTTTTLPPTT | TPSPPTTTTT | TPPPTTTPSP | PITTTTTPLP | ||||
| TTTPSPPIST | TTTPPPTTTP | SPPTTTPSPP | TTTPSPPTTT | TTTPPPTTTP | ||||
| SPPMTTPITP | PASTTTLPPT | TTPSPPTTTT | TTPPPTTTPS | PPTTTPITPP | ||||
| TSTTTLPPTT | TPSPPPTTTT | TPPPTTTPSP | PTTTTPSPPT | ITTTTPPPTT | ||||
| TPSPPTTTTT | TPPPTTTPSP | PTTTPITPPT | STTTLPPTTT | PSPPPTTTTT | ||||
| PPPTTTPSPP | TTTTPSPPIT | TTTTPPPTTT | PSSPITTTPS | PPTTTMTTPS | ||||
| PTTTPSSPIT | TTTTPSSTTT | PSPPPTTMTT | PSPTTTPSPP | TTTMTTLPPT | ||||
| TTSSPLTTTP | LPPSITPPTF | SPFSTTTPTT | PCVPLCNWTG | WLDSGKPNFH | ||||
| KPGGDTELIG | DVCGPGWAAN | ISCRATMYPD | VPIGQLGQTV | VCDVSVGLIC | ||||
| KNEDQKPGGV | IPMAFCLNYE | INVQCCECVT | QPTTMTTTTT | ENPTPPTTTP | ||||
| ITTTTTVTPT | PTPTGTQTPT | TTPITTTTTV | TPTPTPTGTQ | TPTTTPITTT | ||||
| TTVTPTPTPT | GTQTPTTTPI | TTTTTVTPTP | TPTGTQTPTT | TPITTTTTVT | ||||
| PTPTPTGTQT | PTTTPITTTT | TVTPTPTPTG | TQTPTTTPIT | TTTTVTPTPT | ||||
| PTGTQTPTTT | PITTTTTVTP | TPTPTGTQTP | TTTPITTTTT | VTPTPTPTGT | ||||
| QTPTTTPITT | TTTVTPTPTP | TGTQTPTTTP | ITTTTTVTPT | PTPTGTQTPT | ||||
| TTPITTTTTV | TPTPTPTGTQ | TPTTTPITTT | TTVTPTPTPT | GTQTPTTTPI | ||||
| TTTTTVTPTP | TPTGTQTPTT | TPITTTTTVT | PTPTPTGTQT | PTTTPITTTT | ||||
| TVTPTPTPTG | TQTPTTTPIT | TTTTVTPTPT | PTGTQTPTTT | PITTTTTVTP | ||||
| TPTPTGTQTP | TTTPITTTTT | VTPTPTPTGT | QTPTTTPITT | TTTVTPTPTP | ||||
| TGTQTPTTTP | ITTTTTVTPT | PTPTGTQTPT | TTPITTTTTV | TPTPTPTGTQ | ||||
| TPTTTPITTT | TTVTPTPTPT | GTQTPTTTPI | TTTTTVTPTP | TPTGTQTPTT | ||||
| TPITTTTTVT | PTPTPTGTQT | PTTTPITTTT | TVTPTPTPTG | TQTPTTTPIT | ||||
| TTTTVTPTPT | PTGTQTPTTT | PITTTTTVTP | TPTPTGTQTP | TTTPITTTTT | ||||
| VTPTPTPTGT | QTPTTTPITT | TTTVTPTPTP | TGTQTPTTTP | ITTTTTVTPT | ||||
| PTPTGTQTPT | TTPITTTTTV | TPTPTPTGTQ | TPTTTPITTT | TTVTPTPTPT | ||||
| GTQTPTTTPI | TTTTTVTPTP | TPTGTQTPTT | TPITTTTTVT | PTPTPTGTQT | ||||
| PTTTPITTTT | TVTPTPTPTG | TQTPTTTPIT | TTTTVTPTPT | PTGTQTPTTT | ||||
| PITTTTTVTP | TPTPTGTQTP | TTTPITTTTT | VTPTPTPTGT | QTPTTTPITT | ||||
| TTTVTPTPTP | TGTQTPTTTP | ITTTTTVTPT | PTPTGTQTPT | TTPITTTTTV | ||||
| TPTPTPTGTQ | TPTTTPITTT | TTVTPTPTPT | GTQTPTTTPI | TTTTTVTPTP | ||||
| TPTGTQTPTT | TPITTTTTVT | PTPTPTGTQT | PTTTPITTTT | TVTPTPTPTG | ||||
| TQTPTTTPIT | TTTTVTPTPT | PTGTQTPTTT | PITTTTTVTP | TPTPTGTQTP | ||||
| TTTPITTTTT | VTPTPTPTGT | QTPTTTPITT | TTTVTPTPTP | TGTQTPTTTP | ||||
| ITTTTTVTPT | PTPTGTQTPT | TTPITTTTTV | TPTPTPTGTQ | TPTTTPITTT | ||||
| TTVTPTPTPT | GTQTPTTTPI | TTTTTVTPTP | TPTGTQTPTT | TPITTTTTVT | ||||
| PTPTPTGTQT | PTTTPITTTT | TVTPTPTPTG | TQTPTTTPIT | TTTTVTPTPT | ||||
| PTGTQTPTTT | PITTTTTVTP | TPTPTGTQTP | TTTPITTTTT | VTPTPTPTGT | ||||
| QTPTTTPITT | TTTVTPTPTP | TGTQTPTTTP | ITTTTTVTPT | PTPTGTQTPT | ||||
| TTPITTTTTV | TPTPTPTGTQ | TPTTTPITTT | TTVTPTPTPT | GTQTPTTTPI | ||||
| TTTTTVTPTP | TPTGTQTPTT | TPITTTTTVT | PTPTPTGTQT | PTTTPITTTT | ||||
| TVTPTPTPTG | TQTPTTTPIT | TTTTVTPTPT | PTGTQTPTTT | PITTTTTVTP | ||||
| TPTPTGTQTP | TTTPITTTTT | VTPTPTPTGT | QTPTTTPITT | TTTVTPTPTP | ||||
| TGTQTPTTTP | ITTTTTVTPT | PTPTGTQTPT | TTPITTTTTV | TPTPTPTGTQ | ||||
| TPTTTPITTT | TTVTPTPTPT | GTQTPTTTPI | TTTTTVTPTP | TPTGTQTPTT | ||||
| TPITTTTTVT | PTPTPTGTQT | PTTTPITTTT | TVTPTPTPTG | TQTPTTTPIT | ||||
| TTTTVTPTPT | PTGTQTPTTT | PITTTTTVTP | TPTPTGTQTP | TTTPITTTTT | ||||
| VTPTPTPTGT | QTPTTTPITT | TTTVTPTPTP | TGTQTPTTTP | ITTTTTVTPT | ||||
| PTPTGTQTPT | TTPITTTTTV | TPTPTPTGTQ | TPTTTPITTT | TTVTPTPTPT | ||||
| GTQTPTTTPI | TTTTTVTPTP | TPTGTQTPTT | TPITTTTTVT | PTPTPTGTQT | ||||
| PTTTPITTTT | TVTPTPTPTG | TQTPTTTPIT | TTTTVTPTPT | PTGTQTPTTT | ||||
| PITTTTTVTP | TPTPTGTQTP | TTTPITTTTT | VTPTPTPTGT | QTPTTTPITT | ||||
| TTTVTPTPTP | TGTQTPTTTP | ITTTTTVTPT | PTPTGTQTPT | TTPITTTTTV | ||||
| TPTPTPTGTQ | TPTTTPITTT | TTVTPTPTPT | GTQTPTTTPI | TTTTTVTPTP | ||||
| TPTGTQTPTT | TPITTTTTVT | PTPTPTGTQT | PTTTPITTTT | TVTPTPTPTG | ||||
| TQTPTTTPIT | TTTTVTPTPT | PTGTQTPTTT | PITTTTTVTP | TPTPTGTQTP | ||||
| TTTPITTTTT | VTPTPTPTGT | QTPTTTPITT | TTTVTPTPTP | TGTQTGPPTH | ||||
| TSTAPIAELT | TSNPPPESST | PQTSRSTSSP | LTESTTLLST | LPPAIEMTST | ||||
| APPSTPTAPT | TTSGGHTLSP | PPSTTTSPPG | TPTRGTTTGS | SSAPTPSTVQ | ||||
| TTTTSAWTPT | PTPLSTPSII | RTTGLRPYPS | SVLICCVLND | TYYAPGEEVY | ||||
| NGTYGDTCYF | VNCSLSCTLE | FYNWSCPSTP | SPTPTPSKST | PTPSKPSSTP | ||||
| SKPTPGTKPP | ECPDFDPPRQ | ENETWWLCDC | FMATCKYNNT | VEIVKVECEP | ||||
| PPMPTCSNGL | QPVRVEDPDG | CCWHWECDCY | CTGWGDPHYV | TFDGLYYSYQ | ||||
| GNCTYVLVEE | ISPSVDNFGV | YIDNYHCDPN | DKVSCPRTLI | VRHETQEVLI | ||||
| KTVHMMPMQV | QVQVNRQAVA | LPYKKYGLEV | YQSGINYVVD | IPELGVLVSY | ||||
| NGLSFSVRLP | YHRFGNNTKG | QCGTCTNTTS | DDCILPSGEI | VSNCEAAADQ | ||||
| WLVNDPSKPH | CPHSSSTTKR | PAVTVPGGGK | TTPHKDCTPS | PLCQLIKDSL | ||||
| FAQCHALVPP | QHYYDACVFD | SCFMPGSSLE | CASLQAYAAL | CAQQNICLDW | ||||
| RNHTHGACLV | ECPSHREYQA | CGPAEEPTCK | SSSSQQNNTV | LVEGCFCPEG | ||||
| TMNYAPGFDV | CVKTCGCVGP | DNVPREFGEH | FEFDCKNCVC | LEGGSGIICQ | ||||
| PKRCSQKPVT | HCVEDGTYLA | TEVNPADTCC | NITVCKCNTS | LCKEKPSVCP | ||||
| LGFEVKSKMV | PGRCCPFYWC | ESKGVCVHGN | AEYQPGSPVY | SSKCQDCVCT | ||||
| DKVDNNTLLN | VIACTHVPCN | TSCSPGFELM | EAPGECCKKC | EQTHCIIKRP | ||||
| DNQHVILKPG | DFKSDPKNNC | TFFSCVKIHN | QLISSVSNIT | CPNFDASICI | ||||
| PGSITFMPNG | CCKTCTPRNE | TRVPCSTVPV | TTEVSYAGCT | KTVLMNHCSG | ||||
| SCGTFVMYSA | KAQALDHSCS | CCKEEKTSQR | EVVLSCPNGG | SLTHTYTHIE | ||||
| SCQCQDTVCG | LPTGTSRRAR | RSPRHLGSG |
| MUC2 | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ідентифікатори | |||||||||||||||||
| Символи | MUC2, MLP, MUC-2, SMUC, mucin 2, oligomeric mucus/gel-forming | ||||||||||||||||
| Зовнішні ІД | OMIM: 158370 MGI: 1339364 HomoloGene: 136755 GeneCards: MUC2 | ||||||||||||||||
| Пов'язані генетичні захворювання | |||||||||||||||||
| interstitial lung disease[1] | |||||||||||||||||
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| Види | Людина | Миша | |||||||||||||||
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| Локус (UCSC) | Хр. 11: 1.07 – 1.11 Mb | н/д | |||||||||||||||
| PubMed search | [2] | [3] | |||||||||||||||
| Вікідані | |||||||||||||||||
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Цей білок за функцією належить до фосфопротеїнів. Секретований назовні.
Література
- Lidell M.E., Johansson M.E.V., Hansson G.C. (2003). An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway.. J. Biol. Chem. 278: 13944 — 13951. PubMed DOI:10.1074/jbc.M210069200
- Johansson M.E.V., Thomsson K.A., Hansson G.C. (2009). Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein.. J. Proteome Res. 8: 3549 — 3557. PubMed DOI:10.1021/pr9002504
- Gum J.R. Jr., Hicks J.W., Toribara N.W., Siddiki B., Kim Y.S. (1994). Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor.. J. Biol. Chem. 269: 2440 — 2446. PubMed
Примітки
- Захворювання, генетично пов'язані з MUC2 переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:7512 (англ.). Процитовано 1 лютого 2018.
- UniProt, Q02817 (англ.). Процитовано 1 лютого 2018.
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