FCGBP
FCGBP (англ. Fc fragment of IgG binding protein) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 19-ї хромосоми. [3] Довжина поліпептидного ланцюга білка становить 5 405 амінокислот, а молекулярна маса — 572 017[4].
Послідовність амінокислот
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MGALWSWWIL | WAGATLLWGL | TQEASVDLKN | TGREEFLTAF | LQNYQLAYSK | ||||
| AYPRLLISSL | SESPASVSIL | SQADNTSKKV | TVRPGESVMV | NISAKAEMIG | ||||
| SKIFQHAVVI | HSDYAISVQA | LNAKPDTAEL | TLLRPIQALG | TEYFVLTPPG | ||||
| TSARNVKEFA | VVAGAAGASV | SVTLKGSVTF | NGKFYPAGDV | LRVTLQPYNV | ||||
| AQLQSSVDLS | GSKVTASSPV | AVLSGHSCAQ | KHTTCNHVVE | QLLPTSAWGT | ||||
| HYVVPTLASQ | SRYDLAFVVA | SQATKLTYNH | GGITGSRGLQ | AGDVVEFEVR | ||||
| PSWPLYLSAN | VGIQVLLFGT | GAIRNEVTYD | PYLVLIPDVA | AYCPAYVVKS | ||||
| VPGCEGVALV | VAQTKAISGL | TIDGHAVGAK | LTWEAVPGSE | FSYAEVELGT | ||||
| ADMIHTAEAT | TNLGLLTFGL | AKAIGYATAA | DCGRTVLSPV | EPSCEGMQCA | ||||
| AGQRCQVVGG | KAGCVAESTA | VCRAQGDPHY | TTFDGRRYDM | MGTCSYTMVE | ||||
| LCSEDDTLPA | FSVEAKNEHR | GSRRVSYVGL | VTVRAYSHSV | SLTRGEVGFV | ||||
| LVDNQRSRLP | VSLSEGRLRV | YQSGPRAVVE | LVFGLVVTYD | WDCQLALSLP | ||||
| ARFQDQVCGL | CGNYNGDPAD | DFLTPDGALA | PDAVEFASSW | KLDDGDYLCE | ||||
| DGCQNNCPAC | TPGQAQHYEG | DRLCGMLTKL | DGPFAVCHDT | LDPRPFLEQC | ||||
| VYDLCVVGGE | RLSLCRGLSA | YAQACLELGI | SVGDWRSPAN | CPLSCPANSR | ||||
| YELCGPACPT | SCNGAAAPSN | CSGRPCVEGC | VCLPGFVASG | GACVPASSCG | ||||
| CTFQGLQLAP | GQEVWADELC | QRRCTCNGAT | HQVTCRDKQS | CPAGERCSVQ | ||||
| NGLLGCYPDR | FGTCQGSGDP | HYVSFDGRRF | DFMGTCTYLL | VGSCGQNAAL | ||||
| PAFRVLVENE | HRGSQTVSYT | RAVRVEARGV | KVAVRREYPG | QVLVDDVLQY | ||||
| LPFQAADGQV | QVFRQGRDAV | VRTDFGLTVT | YDWNARVTAK | VPSSYAEALC | ||||
| GLCGNFNGDP | ADDLALRGGG | QAANALAFGN | SWQEETRPGC | GATEPGDCPK | ||||
| LDSLVAQQLQ | SKNECGILAD | PKGPFRECHS | KLDPQGAVRD | CVYDRCLLPG | ||||
| QSGPLCDALA | TYAAACQAAG | ATVHPWRSEE | LCPLSCPPHS | HYEACSYGCP | ||||
| LSCGDLPVPG | GCGSECHEGC | VCDEGFALSG | ESCLPLASCG | CVHQGTYHPP | ||||
| GQTFYPGPGC | DSLCHCQEGG | LVSCESSSCG | PHEACQPSGG | SLGCVAVGSS | ||||
| TCQASGDPHY | TTFDGRRFDF | MGTCVYVLAQ | TCGTRPGLHR | FAVLQENVAW | ||||
| GNGRVSVTRV | ITVQVANFTL | RLEQRQWKVT | VNGVDMKLPV | VLANGQIRAS | ||||
| QHGSDVVIET | DFGLRVAYDL | VYYVRVTVPG | NYYQQMCGLC | GNYNGDPKDD | ||||
| FQKPNGSQAG | NANEFGNSWE | EVVPDSPCLP | PTPCPPGSED | CIPSHKCPPE | ||||
| LEKKYQKEEF | CGLLSSPTGP | LSSCHKLVDP | QGPLKDCIFD | LCLGGGNLSI | ||||
| LCSNIHAYVS | ACQAAGGHVE | PWRTETFCPM | ECPPNSHYEL | CADTCSLGCS | ||||
| ALSAPPQCQD | GCAEGCQCDS | GFLYNGQACV | PIQQCGCYHN | GVYYEPEQTV | ||||
| LIDNCRQQCT | CHAGKGMVCQ | EHSCKPGQVC | QPSGGILSCV | TKDPCHGVTC | ||||
| RPQETCKEQG | GQGVCLPNYE | ATCWLWGDPH | YHSFDGRKFD | FQGTCNYVLA | ||||
| TTGCPGVSTQ | GLTPFTVTTK | NQNRGNPAVS | YVRVVTVAAL | GTNISIHKDE | ||||
| IGKVRVNGVL | TALPVSVADG | RISVTQGASK | ALLVADFGLQ | VSYDWNWRVD | ||||
| VTLPSSYHGA | VCGLCGNMDR | NPNNDQVFPN | GTLAPSIPIW | GGSWRAPGWD | ||||
| PLCWDECRGS | CPTCPEDRLE | QYEGPGFCGP | LAPGTGGPFT | TCHAHVPPES | ||||
| FFKGCVLDVC | MGGGDRDILC | KALASYVAAC | QAAGVVIEDW | RAQVGCEITC | ||||
| PENSHYEVCG | SPCPASCPSP | APLTTPAVCE | GPCVEGCQCD | AGFVLSADRC | ||||
| VPLNNGCGCW | ANGTYHEAGS | EFWADGTCSQ | WCRCGPGGGS | LVCTPASCGL | ||||
| GEVCGLLPSG | QHGCQPVSTA | ECQAWGDPHY | VTLDGHRFNF | QGTCEYLLSA | ||||
| PCHGPPLGAE | NFTVTVANEH | RGSQAVSYTR | SVTLQIYNHS | LTLSARWPRK | ||||
| LQVDGVFVTL | PFQLDSLLHA | HLSGADVVVT | TTSGLSLAFD | GDSFVRLRVP | ||||
| AAYAGSLCGL | CGNYNQDPAD | DLKAVGGKPA | GWQVGGAQGC | GECVSKPCPS | ||||
| PCTPEQQESF | GGPDACGVIS | ATDGPLAPCH | GLVPPAQYFQ | GCLLDACQVQ | ||||
| GHPGGLCPAV | ATYVAACQAA | GAQLREWRRP | DFCPFQCPAH | SHYELCGDSC | ||||
| PGSCPSLSAP | EGCESACREG | CVCDAGFVLS | GDTCVPVGQC | GCLHDDRYYP | ||||
| LGQTFYPGPG | CDSLCRCREG | GEVSCEPSSC | GPHETCRPSG | GSLGCVAVGS | ||||
| TTCQASGDPH | YTTFDGRRFD | FMGTCVYVLA | QTCGTRPGLH | RFAVLQENVA | ||||
| WGNGRVSVTR | VITVQVANFT | LRLEQRQWKV | TVNGVDMKLP | VVLANGQIRA | ||||
| SQHGSDVVIE | TDFGLRVAYD | LVYYVRVTVP | GNYYQLMCGL | CGNYNGDPKD | ||||
| DFQKPNGSQA | GNANEFGNSW | EEVVPDSPCL | PPPTCPPGSE | GCIPSEECPP | ||||
| ELEKKYQKEE | FCGLLSSPTG | PLSSCHKLVD | PQGPLKDCIF | DLCLGGGNLS | ||||
| ILCSNIHAYV | SACQAAGGQV | EPWRNETFCP | MECPQNSHYE | LCADTCSLGC | ||||
| SALSAPLQCP | DGCAEGCQCD | SGFLYNGQAC | VPIQQCGCYH | NGAYYEPEQT | ||||
| VLIDNCRQQC | TCHVGKVVVC | QEHSCKPGQV | CQPSGGILSC | VNKDPCHGVT | ||||
| CRPQETCKEQ | GGQGVCLPNY | EATCWLWGDP | HYHSFDGRKF | DFQGTCNYVL | ||||
| ATTGCPGVST | QGLTPFTVTT | KNQNRGNPAV | SYVRVVTVAA | LGTNISIHKD | ||||
| EIGKVRVNGV | LTALPVSVAD | GRISVTQGAS | KALLVADFGL | QVSYDWNWRV | ||||
| DVTLPSSYHG | AVCGLCGNMD | RNPNNDQVFP | NGTLAPSIPI | WGGSWRAPGW | ||||
| DPLCWDECRG | SCPTCPEDRL | EQYEGPGFCG | PLAPGTGGPF | TTCHAHVPPE | ||||
| SFFKGCVLDV | CMGGGDRDIL | CKALASYVAA | CQAAGVVIED | WRAQVGCEIT | ||||
| CPENSHYEVC | GPPCPASCPS | PAPLTTPAVC | EGPCVEGCQC | DAGFVLSADR | ||||
| CVPLNNGCGC | WANGTYHEAG | SEFWADGTCS | QWCRCGPGGG | SLVCTPASCG | ||||
| LGEVCGLLPS | GQHGCQPVST | AECQAWGDPH | YVTLDGHRFD | FQGTCEYLLS | ||||
| APCHGPPLGA | ENFTVTVANE | HRGSQAVSYT | RSVTLQIYNH | SLTLSARWPR | ||||
| KLQVDGVFVT | LPFQLDSLLH | AHLSGADVVV | TTTSGLSLAF | DGDSFVRLRV | ||||
| PAAYAGSLCG | LCGNYNQDPA | DDLKAVGGKP | AGWQVGGAQG | CGECVSKPCP | ||||
| SPCTPEQQES | FGGPDACGVI | SATDGPLAPC | HGLVPPAQYF | QGCLLDACQV | ||||
| QGHPGGLCPA | VATYVAACQA | AGAQLREWRR | PDFCPFQCPA | HSHYELCGDS | ||||
| CPGSCPSLSA | PEGCESACRE | GCVCDAGFVL | SGDTCVPVGQ | CGCLHDDRYY | ||||
| PLGQTFYPGP | GCDSLCRCRE | GGEVSCEPSS | CGPHETCRPS | GGSLGCVAVG | ||||
| STTCQASGDP | HYTTFDGHRF | DFMGTCVYVL | AQTCGTRPGL | HRFAVLQENV | ||||
| AWGNGRVSVT | RVITVQVANF | TLRLEQRQWK | VTVNGVDMKL | PVVLANGQIR | ||||
| ASQHGSDVVI | ETDFGLRVAY | DLVYYVRVTV | PGNYYQLMCG | LCGNYNGDPK | ||||
| DDFQKPNGSQ | AGNANEFGNS | WEEVVPDSPC | LPPPTCPPGS | AGCIPSDKCP | ||||
| PELEKKYQKE | EFCGLLSSPT | GPLSSCHKLV | DPQGPLKDCI | FDLCLGGGNL | ||||
| SILCSNIHAY | VSACQAAGGH | VEPWRNETFC | PMECPQNSHY | ELCADTCSLG | ||||
| CSALSAPLQC | PDGCAEGCQC | DSGFLYNGQA | CVPIQQCGCY | HNGVYYEPEQ | ||||
| TVLIDNCRQQ | CTCHVGKVVV | CQEHSCKPGQ | VCQPSGGILS | CVTKDPCHGV | ||||
| TCRPQETCKE | QGGQGVCLPN | YEATCWLWGD | PHYHSFDGRK | FDFQGTCNYV | ||||
| LATTGCPGVS | TQGLTPFTVT | TKNQNRGNPA | VSYVRVVTVA | ALGTNISIHK | ||||
| DEIGKVRVNG | VLTALPVSVA | DGRISVAQGA | SKALLVADFG | LQVSYDWNWR | ||||
| VDVTLPSSYH | GAVCGLCGNM | DRNPNNDQVF | PNGTLAPSIP | IWGGSWRAPG | ||||
| WDPLCWDECR | GSCPTCPEDR | LEQYEGPGFC | GPLSSGTGGP | FTTCHAHVPP | ||||
| ESFFKGCVLD | VCMGGGDRDI | LCKALASYVA | ACQAAGVVIE | DWRAQVGCEI | ||||
| TCPENSHYEV | CGPPCPASCP | SPAPLTTPAV | CEGPCVEGCQ | CDAGFVLSAD | ||||
| RCVPLNNGCG | CWANGTYHEA | GSEFWADGTC | SQWCRCGPGG | GSLVCTPASC | ||||
| GLGEVCGLLP | SGQHGCQPVS | TAECQAWGDP | HYVTLDGHRF | DFQGTCEYLL | ||||
| SAPCHGPPLG | AENFTVTVAN | EHRGSQAVSY | TRSVTLQIYN | HSLTLSARWP | ||||
| RKLQVDGVFV | ALPFQLDSLL | HAHLSGADVV | VTTTSGLSLA | FDGDSFVRLR | ||||
| VPAAYAASLC | GLCGNYNQDP | ADDLKAVGGK | PAGWQVGGAQ | GCGECVSKPC | ||||
| PSPCTPEQQE | SFGGPDACGV | ISATDGPLAP | CHGLVPPAQY | FQGCLLDACQ | ||||
| VQGHPGGLCP | AVATYVAACQ | AAGAQLGEWR | RPDFCPLQCP | AHSHYELCGD | ||||
| SCPVSCPSLS | APEGCESACR | EGCVCDAGFV | LSGDTCVPVG | QCGCLHDGRY | ||||
| YPLGEVFYPG | PECERRCECG | PGGHVTCQEG | AACGPHEECR | LEDGVQACHA | ||||
| TGCGRCLANG | GIHYITLDGR | VYDLHGSCSY | VLAQVCHPKP | GDEDFSIVLE | ||||
| KNAAGDLQRL | LVTVAGQVVS | LAQGQQVTVD | GEAVALPVAV | GRVRVTAEGR | ||||
| NMVLQTTKGL | RLLFDGDAHL | LMSIPSPFRG | RLCGLCGNFN | GNWSDDFVLP | ||||
| NGSAASSVET | FGAAWRAPGS | SKGCGEGCGP | QGCPVCLAEE | TAPYESNEAC | ||||
| GQLRNPQGPF | ATCQAVLSPS | EYFRQCVYDL | CAQKGDKAFL | CRSLAAYTAA | ||||
| CQAAGVAVKP | WRTDSFCPLH | CPAHSHYSIC | TRTCQGSCAA | LSGLTGCTTR | ||||
| CFEGCECDDR | FLLSQGVCIP | VQDCGCTHNG | RYLPVNSSLL | TSDCSERCSC | ||||
| SSSSGLTCQA | AGCPPGRVCE | VKAEARNCWA | TRGLCVLSVG | ANLTTFDGAR | ||||
| GATTSPGVYE | LSSRCPGLQN | TIPWYRVVAE | VQICHGKTEA | VGQVHIFFQD | ||||
| GMVTLTPNKG | VWVNGLRVDL | PAEKLASVSV | SRTPDGSLLV | RQKAGVQVWL | ||||
| GANGKVAVIV | SNDHAGKLCG | ACGNFDGDQT | NDWHDSQEKP | AMEKWRAQDF | ||||
| SPCYG |
| FCGBP | |||||||
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| Ідентифікатори | |||||||
| Символи | FCGBP, FC(GAMMA)BP, Fc fragment of IgG binding protein, Fc gamma binding protein | ||||||
| Зовнішні ІД | OMIM: 617553 MGI: 2444336 HomoloGene: 68369 GeneCards: FCGBP | ||||||
| Ортологи | |||||||
| Види | Людина | Миша | |||||
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| RefSeq (мРНК) |
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| RefSeq (білок) |
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| Локус (UCSC) | Хр. 19: 39.86 – 39.93 Mb | Хр. 7: 28.07 – 28.12 Mb | |||||
| PubMed search | [1] | [2] | |||||
| Вікідані | |||||||
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Секретований назовні.
Література
- Johansson M.E.V., Thomsson K.A., Hansson G.C. (2009). Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein.. J. Proteome Res. 8: 3549 — 3557. PubMed DOI:10.1021/pr9002504
Примітки
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:13572 (англ.). Процитовано 21 серпня 2017.
- UniProt, Q9Y6R7 (англ.). Процитовано 21 серпня 2017.
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