GATA3

GATA3 (англ. GATA binding protein 3) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 10-ї хромосоми.[4] Довжина поліпептидного ланцюга білка становить 443 амінокислот, а молекулярна маса — 47 916[5].

GATA3
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 4HC7, 4HC9, 4HCA
Ідентифікатори
Символи	GATA3, HDR, HDRS, GATA binding protein 3
Зовнішні ІД	OMIM: 131320 MGI: 95663 HomoloGene: 1550 GeneCards: GATA3
Пов'язані генетичні захворювання
ревматоїдний артрит, Гострий лімфобластний лейкоз, лімфогранульоматоз, hypoparathyroidism-deafness-renal disease syndrome[1]
Онтологія гена Молекулярна функція • RNA polymerase II transcription regulatory region sequence-specific DNA binding • HMG box domain binding • chromatin binding • зв'язування з іоном металу • DNA binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • interleukin-2 receptor binding • core promoter sequence-specific DNA binding • GO:0000975 transcription cis-regulatory region binding • protein dimerization activity • E-box binding • GO:0001948 protein binding • zinc ion binding • transcription factor binding • GO:0001105 transcription coactivator activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001104 transcription coregulator activity Клітинна компонента • клітинне ядро • transcription regulator complex • Нуклеоплазма Біологічний процес • negative regulation of cell population proliferation • regulation of establishment of cell polarity • ureteric bud formation • negative regulation of cell cycle • thymic T cell selection • response to ethanol • positive regulation of T cell differentiation • erythrocyte differentiation • inner ear morphogenesis • cell maturation • regulation of histone H3-K27 methylation • cardiac right ventricle morphogenesis • phosphatidylinositol 3-kinase signaling • norepinephrine biosynthetic process • ear development • homeostasis of number of cells • sympathetic nervous system development • T-helper 2 cell differentiation • regulation of cellular response to X-ray • Детермінація • post-embryonic development • cellular response to BMP stimulus • mesonephros development • neuron differentiation • regulation of neuron apoptotic process • Сигнальна трансдукція • cellular response to cytokine stimulus • cellular response to interleukin-4 • T cell receptor signaling pathway • neuron migration • positive regulation of interleukin-5 production • regulation of CD4-positive, alpha-beta T cell differentiation • parathyroid gland development • negative regulation of DNA demethylation • positive regulation of interleukin-4 production • negative regulation of mammary gland epithelial cell proliferation • regulation of transcription by RNA polymerase II • thymus development • нейробіологія розвитку • otic vesicle development • regulation of transcription, DNA-templated • positive regulation of T-helper 2 cell cytokine production • regulation of nephron tubule epithelial cell differentiation • positive regulation of thyroid hormone generation • lymphocyte migration • negative regulation of interleukin-2 production • regulation of neuron projection development • uterus development • axon guidance • mesenchymal to epithelial transition • negative regulation of cell proliferation involved in mesonephros development • aortic valve morphogenesis • cellular response to tumor necrosis factor • negative regulation of fat cell differentiation • anatomical structure morphogenesis • cellular response to interferon-alpha • negative regulation of transcription, DNA-templated • T cell differentiation • response to virus • negative regulation of endothelial cell apoptotic process • Вроджений імунітет • canonical Wnt signaling pathway involved in metanephric kidney development • positive regulation of transcription regulatory region DNA binding • positive regulation of endothelial cell migration • positive regulation of interleukin-13 production • in utero embryonic development • negative regulation of interferon-gamma production • humoral immune response • developmental growth • kidney development • positive regulation of ureteric bud formation • positive regulation of gene expression • mast cell differentiation • positive regulation of histone H3-K9 acetylation • positive regulation of cell differentiation • negative regulation of transcription by RNA polymerase II • male gonad development • nephric duct morphogenesis • ventricular septum development • positive regulation of cytokine production • lens development in camera-type eye • negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation • transcription, DNA-templated • negative regulation of gene expression • parathyroid hormone secretion • nephric duct formation • immune system process • negative regulation of inflammatory response • pharyngeal system development • embryonic organ development • response to estrogen • зсідання крові • negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation • positive regulation of signal transduction • ureter maturation • positive regulation of histone H3-K14 acetylation • positive regulation of transcription, DNA-templated • response to gamma radiation • cell morphogenesis • embryonic hemopoiesis • positive regulation of transcription by RNA polymerase II • negative regulation of cell motility • pro-T cell differentiation • TOR signaling • type IV hypersensitivity • defense response • regulation of histone H3-K4 methylation • renal system development • positive regulation of protein kinase B signaling • cell activation • Ремоделювання хроматину • T cell differentiation in thymus • cochlea development • transcription by RNA polymerase II • protein deubiquitination • anatomical structure formation involved in morphogenesis • regulation of hematopoietic stem cell differentiation • cytokine-mediated signaling pathway • heart development • animal organ morphogenesis • Гістогенез • cell development • digestive tract development • immune system development • regulation of epithelial cell differentiation • ureter morphogenesis Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	2625	14462
Ensembl	ENSG00000107485	ENSMUSG00000015619
UniProt	P23771	P23772
RefSeq (мРНК)	NM_001002295 NM_002051	NM_008091 NM_001355110 NM_001355111 NM_001355112
RefSeq (білок)	NP_001002295 NP_002042	NP_032117 NP_001342039 NP_001342040 NP_001342041
Локус (UCSC)	Хр. 10: 8.05 – 8.08 Mb	Хр. 2: 9.86 – 9.89 Mb
PubMed search	[2]	[3]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Кодований геном білок за функціями належить до активаторів, фосфопротеїнів. Задіяний у таких біологічних процесах, як імунітет, вроджений імунітет, транскрипція, регуляція транскрипції, альтернативний сплайсинг. Білок має сайт для зв'язування з іонами металів, іоном цинку, ДНК. Локалізований у ядрі.