HMCN1
HMCN1 (англ. Hemicentin 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. [3] Довжина поліпептидного ланцюга білка становить 5 635 амінокислот, а молекулярна маса — 613 390[4].
Послідовність амінокислот
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MISWEVVHTV | FLFALLYSSL | AQDASPQSEI | RAEEIPEGAS | TLAFVFDVTG | ||||
| SMYDDLVQVI | EGASKILETS | LKRPKRPLFN | FALVPFHDPE | IGPVTITTDP | ||||
| KKFQYELREL | YVQGGGDCPE | MSIGAIKIAL | EISLPGSFIY | VFTDARSKDY | ||||
| RLTHEVLQLI | QQKQSQVVFV | LTGDCDDRTH | IGYKVYEEIA | STSSGQVFHL | ||||
| DKKQVNEVLK | WVEEAVQASK | VHLLSTDHLE | QAVNTWRIPF | DPSLKEVTVS | ||||
| LSGPSPMIEI | RNPLGKLIKK | GFGLHELLNI | HNSAKVVNVK | EPEAGMWTVK | ||||
| TSSSGRHSVR | ITGLSTIDFR | AGFSRKPTLD | FKKTVSRPVQ | GIPTYVLLNT | ||||
| SGISTPARID | LLELLSISGS | SLKTIPVKYY | PHRKPYGIWN | ISDFVPPNEA | ||||
| FFLKVTGYDK | DDYLFQRVSS | VSFSSIVPDA | PKVTMPEKTP | GYYLQPGQIP | ||||
| CSVDSLLPFT | LSFVRNGVTL | GVDQYLKESA | SVNLDIAKVT | LSDEGFYECI | ||||
| AVSSAGTGRA | QTFFDVSEPP | PVIQVPNNVT | VTPGERAVLT | CLIISAVDYN | ||||
| LTWQRNDRDV | RLAEPARIRT | LANLSLELKS | VKFNDAGEYH | CMVSSEGGSS | ||||
| AASVFLTVQE | PPKVTVMPKN | QSFTGGSEVS | IMCSATGYPK | PKIAWTVNDM | ||||
| FIVGSHRYRM | TSDGTLFIKN | AAPKDAGIYG | CLASNSAGTD | KQNSTLRYIE | ||||
| APKLMVVQSE | LLVALGDITV | MECKTSGIPP | PQVKWFKGDL | ELRPSTFLII | ||||
| DPLLGLLKIQ | ETQDLDAGDY | TCVAINEAGR | ATGKITLDVG | SPPVFIQEPA | ||||
| DVSMEIGSNV | TLPCYVQGYP | EPTIKWRRLD | NMPIFSRPFS | VSSISQLRTG | ||||
| ALFILNLWAS | DKGTYICEAE | NQFGKIQSET | TVTVTGLVAP | LIGISPSVAN | ||||
| VIEGQQLTLP | CTLLAGNPIP | ERRWIKNSAM | LLQNPYITVR | SDGSLHIERV | ||||
| QLQDGGEYTC | VASNVAGTNN | KTTSVVVHVL | PTIQHGQQIL | STIEGIPVTL | ||||
| PCKASGNPKP | SVIWSKKGEL | ISTSSAKFSA | GADGSLYVVS | PGGEESGEYV | ||||
| CTATNTAGYA | KRKVQLTVYV | RPRVFGDQRG | LSQDKPVEIS | VLAGEEVTLP | ||||
| CEVKSLPPPI | ITWAKETQLI | SPFSPRHTFL | PSGSMKITET | RTSDSGMYLC | ||||
| VATNIAGNVT | QAVKLNVHVP | PKIQRGPKHL | KVQVGQRVDI | PCNAQGTPLP | ||||
| VITWSKGGST | MLVDGEHHVS | NPDGTLSIDQ | ATPSDAGIYT | CVATNIAGTD | ||||
| ETEITLHVQE | PPTVEDLEPP | YNTTFQERVA | NQRIEFPCPA | KGTPKPTIKW | ||||
| LHNGRELTGR | EPGISILEDG | TLLVIASVTP | YDNGEYICVA | VNEAGTTERK | ||||
| YNLKVHVPPV | IKDKEQVTNV | SVLLNQLTNL | FCEVEGTPSP | IIMWYKDNVQ | ||||
| VTESSTIQTV | NNGKILKLFR | ATPEDAGRYS | CKAINIAGTS | QKYFNIDVLV | ||||
| PPTIIGTNFP | NEVSVVLNRD | VALECQVKGT | PFPDIHWFKD | GKPLFLGDPN | ||||
| VELLDRGQVL | HLKNARRNDK | GRYQCTVSNA | AGKQAKDIKL | TIYIPPSIKG | ||||
| GNVTTDISVL | INSLIKLECE | TRGLPMPAIT | WYKDGQPIMS | SSQALYIDKG | ||||
| QYLHIPRAQV | SDSATYTCHV | ANVAGTAEKS | FHVDVYVPPM | IEGNLATPLN | ||||
| KQVVIAHSLT | LECKAAGNPS | PILTWLKDGV | PVKANDNIRI | EAGGKKLEIM | ||||
| SAQEIDRGQY | ICVATSVAGE | KEIKYEVDVL | VPPAIEGGDE | TSYFIVMVNN | ||||
| LLELDCHVTG | SPPPTIMWLK | DGQLIDERDG | FKILLNGRKL | VIAQAQVSNT | ||||
| GLYRCMAANT | AGDHKKEFEV | TVHVPPTIKS | SGLSERVVVK | YKPVALQCIA | ||||
| NGIPNPSITW | LKDDQPVNTA | QGNLKIQSSG | RVLQIAKTLL | EDAGRYTCVA | ||||
| TNAAGETQQH | IQLHVHEPPS | LEDAGKMLNE | TVLVSNPVQL | ECKAAGNPVP | ||||
| VITWYKDNRL | LSGSTSMTFL | NRGQIIDIES | AQISDAGIYK | CVAINSAGAT | ||||
| ELFYSLQVHV | APSISGSNNM | VAVVVNNPVR | LECEARGIPA | PSLTWLKDGS | ||||
| PVSSFSNGLQ | VLSGGRILAL | TSAQISDTGR | YTCVAVNAAG | EKQRDIDLRV | ||||
| YVPPNIMGEE | QNVSVLISQA | VELLCQSDAI | PPPTLTWLKD | GHPLLKKPGL | ||||
| SISENRSVLK | IEDAQVQDTG | RYTCEATNVA | GKTEKNYNVN | IWVPPNIGGS | ||||
| DELTQLTVIE | GNLISLLCES | SGIPPPNLIW | KKKGSPVLTD | SMGRVRILSG | ||||
| GRQLQISIAE | KSDAALYSCV | ASNVAGTAKK | EYNLQVYIRP | TITNSGSHPT | ||||
| EIIVTRGKSI | SLECEVQGIP | PPTVTWMKDG | HPLIKAKGVE | ILDEGHILQL | ||||
| KNIHVSDTGR | YVCVAVNVAG | MTDKKYDLSV | HAPPSIIGNH | RSPENISVVE | ||||
| KNSVSLTCEA | SGIPLPSITW | FKDGWPVSLS | NSVRILSGGR | MLRLMQTTME | ||||
| DAGQYTCVVR | NAAGEERKIF | GLSVLVPPHI | VGENTLEDVK | VKEKQSVTLT | ||||
| CEVTGNPVPE | ITWHKDGQPL | QEDEAHHIIS | GGRFLQITNV | QVPHTGRYTC | ||||
| LASSPAGHKS | RSFSLNVFVS | PTIAGVGSDG | NPEDVTVILN | SPTSLVCEAY | ||||
| SYPPATITWF | KDGTPLESNR | NIRILPGGRT | LQILNAQEDN | AGRYSCVATN | ||||
| EAGEMIKHYE | VKVYIPPIIN | KGDLWGPGLS | PKEVKIKVNN | TLTLECEAYA | ||||
| IPSASLSWYK | DGQPLKSDDH | VNIAANGHTL | QIKEAQISDT | GRYTCVASNI | ||||
| AGEDELDFDV | NIQVPPSFQK | LWEIGNMLDT | GRNGEAKDVI | INNPISLYCE | ||||
| TNAAPPPTLT | WYKDGHPLTS | SDKVLILPGG | RVLQIPRAKV | EDAGRYTCVA | ||||
| VNEAGEDSLQ | YDVRVLVPPI | IKGANSDLPE | EVTVLVNKSA | LIECLSSGSP | ||||
| APRNSWQKDG | QPLLEDDHHK | FLSNGRILQI | LNTQITDIGR | YVCVAENTAG | ||||
| SAKKYFNLNV | HVPPSVIGPK | SENLTVVVNN | FISLTCEVSG | FPPPDLSWLK | ||||
| NEQPIKLNTN | TLIVPGGRTL | QIIRAKVSDG | GEYTCIAINQ | AGESKKKFSL | ||||
| TVYVPPSIKD | HDSESLSVVN | VREGTSVSLE | CESNAVPPPV | ITWYKNGRMI | ||||
| TESTHVEILA | DGQMLHIKKA | EVSDTGQYVC | RAINVAGRDD | KNFHLNVYVP | ||||
| PSIEGPEREV | IVETISNPVT | LTCDATGIPP | PTIAWLKNHK | RIENSDSLEV | ||||
| RILSGGSKLQ | IARSQHSDSG | NYTCIASNME | GKAQKYYFLS | IQVPPSVAGA | ||||
| EIPSDVSVLL | GENVELVCNA | NGIPTPLIQW | LKDGKPIASG | ETERIRVSAN | ||||
| GSTLNIYGAL | TSDTGKYTCV | ATNPAGEEDR | IFNLNVYVTP | TIRGNKDEAE | ||||
| KLMTLVDTSI | NIECRATGTP | PPQINWLKNG | LPLPLSSHIR | LLAAGQVIRI | ||||
| VRAQVSDVAV | YTCVASNRAG | VDNKHYNLQV | FAPPNMDNSM | GTEEITVLKG | ||||
| SSTSMACITD | GTPAPSMAWL | RDGQPLGLDA | HLTVSTHGMV | LQLLKAETED | ||||
| SGKYTCIASN | EAGEVSKHFI | LKVLEPPHIN | GSEEHEEISV | IVNNPLELTC | ||||
| IASGIPAPKM | TWMKDGRPLP | QTDQVQTLGG | GEVLRISTAQ | VEDTGRYTCL | ||||
| ASSPAGDDDK | EYLVRVHVPP | NIAGTDEPRD | ITVLRNRQVT | LECKSDAVPP | ||||
| PVITWLRNGE | RLQATPRVRI | LSGGRYLQIN | NADLGDTANY | TCVASNIAGK | ||||
| TTREFILTVN | VPPNIKGGPQ | SLVILLNKST | VLECIAEGVP | TPRITWRKDG | ||||
| AVLAGNHARY | SILENGFLHI | QSAHVTDTGR | YLCMATNAAG | TDRRRIDLQV | ||||
| HVPPSIAPGP | TNMTVIVNVQ | TTLACEATGI | PKPSINWRKN | GHLLNVDQNQ | ||||
| NSYRLLSSGS | LVIISPSVDD | TATYECTVTN | GAGDDKRTVD | LTVQVPPSIA | ||||
| DEPTDFLVTK | HAPAVITCTA | SGVPFPSIHW | TKNGIRLLPR | GDGYRILSSG | ||||
| AIEILATQLN | HAGRYTCVAR | NAAGSAHRHV | TLHVHEPPVI | QPQPSELHVI | ||||
| LNNPILLPCE | ATGTPSPFIT | WQKEGINVNT | SGRNHAVLPS | GGLQISRAVR | ||||
| EDAGTYMCVA | QNPAGTALGK | IKLNVQVPPV | ISPHLKEYVI | AVDKPITLSC | ||||
| EADGLPPPDI | TWHKDGRAIV | ESIRQRVLSS | GSLQIAFVQP | GDAGHYTCMA | ||||
| ANVAGSSSTS | TKLTVHVPPR | IRSTEGHYTV | NENSQAILPC | VADGIPTPAI | ||||
| NWKKDNVLLA | NLLGKYTAEP | YGELILENVV | LEDSGFYTCV | ANNAAGEDTH | ||||
| TVSLTVHVLP | TFTELPGDVS | LNKGEQLRLS | CKATGIPLPK | LTWTFNNNII | ||||
| PAHFDSVNGH | SELVIERVSK | EDSGTYVCTA | ENSVGFVKAI | GFVYVKEPPV | ||||
| FKGDYPSNWI | EPLGGNAILN | CEVKGDPTPT | IQWNRKGVDI | EISHRIRQLG | ||||
| NGSLAIYGTV | NEDAGDYTCV | ATNEAGVVER | SMSLTLQSPP | IITLEPVETV | ||||
| INAGGKIILN | CQATGEPQPT | ITWSRQGHSI | SWDDRVNVLS | NNSLYIADAQ | ||||
| KEDTSEFECV | ARNLMGSVLV | RVPVIVQVHG | GFSQWSAWRA | CSVTCGKGIQ | ||||
| KRSRLCNQPL | PANGGKPCQG | SDLEMRNCQN | KPCPVDGSWS | EWSLWEECTR | ||||
| SCGRGNQTRT | RTCNNPSVQH | GGRPCEGNAV | EIIMCNIRPC | PVHGAWSAWQ | ||||
| PWGTCSESCG | KGTQTRARLC | NNPPPAFGGS | YCDGAETQMQ | VCNERNCPIH | ||||
| GKWATWASWS | ACSVSCGGGA | RQRTRGCSDP | VPQYGGRKCE | GSDVQSDFCN | ||||
| SDPCPTHGNW | SPWSGWGTCS | RTCNGGQMRR | YRTCDNPPPS | NGGRACGGPD | ||||
| SQIQRCNTDM | CPVDGSWGSW | HSWSQCSASC | GGGEKTRKRL | CDHPVPVKGG | ||||
| RPCPGDTTQV | TRCNVQACPG | GPQRARGSVI | GNINDVEFGI | AFLNATITDS | ||||
| PNSDTRIIRA | KITNVPRSLG | SAMRKIVSIL | NPIYWTTAKE | IGEAVNGFTL | ||||
| TNAVFKRETQ | VEFATGEILQ | MSHIARGLDS | DGSLLLDIVV | SGYVLQLQSP | ||||
| AEVTVKDYTE | DYIQTGPGQL | YAYSTRLFTI | DGISIPYTWN | HTVFYDQAQG | ||||
| RMPFLVETLH | ASSVESDYNQ | IEETLGFKIH | ASISKGDRSN | QCPSGFTLDS | ||||
| VGPFCADEDE | CAAGNPCSHS | CHNAMGTYYC | SCPKGLTIAA | DGRTCQDIDE | ||||
| CALGRHTCHA | GQDCDNTIGS | YRCVVRCGSG | FRRTSDGLSC | QDINECQESS | ||||
| PCHQRCFNAI | GSFHCGCEPG | YQLKGRKCMD | VNECRQNVCR | PDQHCKNTRG | ||||
| GYKCIDLCPN | GMTKAENGTC | IDIDECKDGT | HQCRYNQICE | NTRGSYRCVC | ||||
| PRGYRSQGVG | RPCMDINECE | QVPKPCAHQC | SNTPGSFKCI | CPPGQHLLGD | ||||
| GKSCAGLERL | PNYGTQYSSY | NLARFSPVRN | NYQPQQHYRQ | YSHLYSSYSE | ||||
| YRNSRTSLSR | TRRTIRKTCP | EGSEASHDTC | VDIDECENTD | ACQHECKNTF | ||||
| GSYQCICPPG | YQLTHNGKTC | QDIDECLEQN | VHCGPNRMCF | NMRGSYQCID | ||||
| TPCPPNYQRD | PVSGFCLKNC | PPNDLECALS | PYALEYKLVS | LPFGIATNQD | ||||
| LIRLVAYTQD | GVMHPRTTFL | MVDEEQTVPF | ALRDENLKGV | VYTTRPLREA | ||||
| ETYRMRVRAS | SYSANGTIEY | QTTFIVYIAV | SAYPY |
Задіяний у таких біологічних процесах як клітинний цикл, поділ клітини, поліморфізм, альтернативний сплайсинг. Білок має сайт для зв'язування з іоном кальцію. Локалізований у цитоплазмі, клітинних контактах, позаклітинному матриксі, базальній мембрані. Також секретований назовні.
Література
Примітки
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:19194 (англ.). Процитовано 28 серпня 2017.
- UniProt, Q96RW7 (англ.). Процитовано 28 серпня 2017.
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