IL10

IL10 (англ. Interleukin 10) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. [4] Довжина поліпептидного ланцюга білка становить 178 амінокислот, а молекулярна маса — 20 517[5].

IL10
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 1ILK, 1INR, 1J7V, 1LK3, 1Y6K, 2ILK, 2H24
Ідентифікатори
Символи	IL10, CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin 10
Зовнішні ІД	OMIM: 124092 MGI: 96537 HomoloGene: 478 GeneCards: IL10
Пов'язані генетичні захворювання
синдром Бехчета, неспецифічний виразковий коліт[1]
Онтологія гена Молекулярна функція • GO:0001948 protein binding • growth factor activity • cytokine activity • interleukin-10 receptor binding • protein dimerization activity Клітинна компонента • extracellular region • extracellular space Біологічний процес • negative regulation of chronic inflammatory response to antigenic stimulus • positive regulation of MHC class II biosynthetic process • negative regulation of endothelial cell apoptotic process • кровотворення • negative regulation of interferon-gamma production • regulation of sensory perception of pain • positive regulation of B cell apoptotic process • negative regulation of chemokine (C-C motif) ligand 5 production • response to inactivity • negative regulation of cytokine activity • negative regulation of interleukin-1 production • cellular response to hepatocyte growth factor stimulus • cellular response to estradiol stimulus • negative regulation of interleukin-6 production • Старіння людини • positive regulation of DNA-binding transcription factor activity • negative regulation of apoptotic process • GO:0002719 negative regulation of cytokine production involved in immune response • response to glucocorticoid • cytoplasmic sequestering of NF-kappaB • negative regulation of interleukin-18 production • negative regulation of MHC class II biosynthetic process • response to activity • response to organic substance • response to carbon monoxide • leukocyte chemotaxis • type 2 immune response • negative regulation of myeloid dendritic cell activation • response to insulin • negative regulation of interleukin-8 production • response to lipopolysaccharide • B cell proliferation • negative regulation of T cell proliferation • negative regulation of nitric oxide biosynthetic process • branching involved in labyrinthine layer morphogenesis • defense response to bacterium • regulation of complement-dependent cytotoxicity • Імунна відповідь • Регуляція експресії генів • B cell differentiation • regulation of isotype switching • negative regulation of tumor necrosis factor production • negative regulation of membrane protein ectodomain proteolysis • inflammatory response • cellular response to lipopolysaccharide • negative regulation of B cell proliferation • negative regulation of inflammatory response • negative regulation of cytokine production • positive regulation of transcription by RNA polymerase II • negative regulation of interleukin-12 production • defense response to protozoan • negative regulation of sensory perception of pain • positive regulation of macrophage activation • liver regeneration • regulation of synapse organization • positive regulation of endothelial cell proliferation • negative regulation of cell population proliferation • negative regulation of heterotypic cell-cell adhesion • positive regulation of heterotypic cell-cell adhesion • positive regulation of cell cycle • negative regulation of mitotic cell cycle • endothelial cell apoptotic process • regulation of response to wounding • negative regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • interleukin-12-mediated signaling pathway • positive regulation of transcription, DNA-templated • negative regulation of autophagy • cytokine-mediated signaling pathway • positive regulation of receptor signaling pathway via JAK-STAT • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of hydrogen peroxide-induced neuron death • positive regulation of sprouting angiogenesis Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	3586	16153
Ensembl	ENSG00000136634	ENSMUSG00000016529
UniProt	P22301	P18893
RefSeq (мРНК)	NM_000572	NM_010548
RefSeq (білок)	NP_000563	NP_034678
Локус (UCSC)	Хр. 1: 206.77 – 206.77 Mb	Хр. 1: 131.02 – 131.02 Mb
PubMed search	[2]	[3]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Кодований геном білок за функцією належить до цитокінів. Секретований назовні.