IL1B

IL1B (англ. Interleukin 1 beta) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 2-ї хромосоми. [3] Довжина поліпептидного ланцюга білка становить 269 амінокислот, а молекулярна маса — 30 748[4].

IL1B
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 1HIB, 1I1B, 1IOB, 1ITB, 1L2H, 1S0L, 1T4Q, 1TOO, 1TP0, 1TWE, 1TWM, 21BI, 2I1B, 2KH2, 2NVH, 31BI, 3O4O, 3POK, 41BI, 4DEP, 4G6J, 4G6M, 4GAI, 4I1B, 5I1B, 6I1B, 7I1B, 9ILB, 4GAF, 5BVP
Ідентифікатори
Символи	IL1B, IL-1, IL1-BETA, IL1F2, interleukin 1 beta, IL1beta
Зовнішні ІД	OMIM: 147720 MGI: 96543 HomoloGene: 481 GeneCards: IL1B
Онтологія гена Молекулярна функція • protein domain specific binding • interleukin-1 receptor binding • cytokine activity • integrin binding • GO:0001948 protein binding Клітинна компонента • цитоплазма • гіалоплазма • extracellular region • Лізосома • Екзосома • secretory granule • везикула • extracellular space Біологічний процес • positive regulation of protein phosphorylation • smooth muscle adaptation • positive regulation of calcidiol 1-monooxygenase activity • negative regulation of insulin receptor signaling pathway • cellular response to mechanical stimulus • positive regulation of histone phosphorylation • positive regulation of interleukin-8 production • positive regulation of mitotic nuclear division • response to carbohydrate • embryo implantation • regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of cell population proliferation • Апоптоз • cellular response to organic substance • positive regulation of phagocytosis • regulation of insulin secretion • neutrophil chemotaxis • positive regulation of transcription, DNA-templated • positive regulation of protein export from nucleus • positive regulation of prostaglandin secretion • positive regulation of myosin light chain kinase activity • negative regulation of MAP kinase activity • positive regulation of T cell proliferation • positive regulation of interleukin-6 production • inflammatory response • negative regulation of lipid metabolic process • sequestering of triglyceride • hyaluronan biosynthetic process • positive regulation of heterotypic cell-cell adhesion • positive regulation of lipid catabolic process • cellular response to organic cyclic compound • positive regulation of fever generation • positive regulation of DNA-binding transcription factor activity • positive regulation of angiogenesis • response to lipopolysaccharide • positive regulation of NF-kappaB transcription factor activity • positive regulation of granulocyte macrophage colony-stimulating factor production • Імунна відповідь • ectopic germ cell programmed cell death • leukocyte migration • lipopolysaccharide-mediated signaling pathway • positive regulation of vascular endothelial growth factor receptor signaling pathway • positive regulation of cell adhesion molecule production • response to ATP • monocyte aggregation • protein kinase B signaling • positive regulation of nitric oxide biosynthetic process • cell-cell signaling • positive regulation of monocyte chemotactic protein-1 production • regulation of nitric-oxide synthase activity • positive regulation of membrane protein ectodomain proteolysis • positive regulation of interferon-gamma production • MAPK cascade • positive regulation of histone acetylation • positive regulation of gene expression • negative regulation of glucose transmembrane transport • interleukin-1 beta production • positive regulation of T cell mediated immunity • extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of vascular endothelial growth factor production • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of lipid catabolic process • negative regulation of adiponectin secretion • regulation of establishment of endothelial barrier • positive regulation of cell division • Сигнальна трансдукція • positive regulation of transcription by RNA polymerase II • cytokine-mediated signaling pathway • regulation of defense response to virus by host • fever generation • positive regulation of JNK cascade • positive regulation of cell population proliferation • regulation of signaling receptor activity • positive regulation of epithelial to mesenchymal transition • positive regulation of cell migration • interleukin-6 production • astrocyte activation • regulation of neurogenesis • negative regulation of neurogenesis • negative regulation of synaptic transmission • positive regulation of glial cell proliferation • regulation of ERK1 and ERK2 cascade • interleukin-1-mediated signaling pathway • cellular response to lipopolysaccharide • positive regulation of neuroinflammatory response • positive regulation of p38MAPK cascade • positive regulation of NIK/NF-kappaB signaling • positive regulation of T-helper 1 cell cytokine production • positive regulation of prostaglandin biosynthetic process • positive regulation of complement activation • positive regulation of inflammatory response • response to interleukin-1 • positive regulation of RNA biosynthetic process Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	3553	16176
Ensembl	ENSG00000125538	ENSMUSG00000027398
UniProt	P01584	P10749
RefSeq (мРНК)	NM_000576	NM_008361
RefSeq (білок)	NP_000567	NP_032387
Локус (UCSC)	Хр. 2: 112.83 – 112.84 Mb	Хр. 2: 129.36 – 129.37 Mb
PubMed search	[1]	[2]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Кодований геном білок за функціями належить до цитокінів, мітогенів. Задіяний у таких біологічних процесах як запальна відповідь, поліморфізм. Локалізований у цитоплазмі, лізосомі. Також секретований назовні.