JUN

JUN (англ. Jun proto-oncogene, AP-1 transcription factor subunit) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. [3] Довжина поліпептидного ланцюга білка становить 331 амінокислот, а молекулярна маса — 35 676[4].

JUN
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 1A02, 1JNM, 1JUN, 1S9K, 1T2K, 1FOS
Ідентифікатори
Символи	JUN, AP-1, AP1, c-Jun, Jun proto-oncogene, AP-1 transcription factor subunit, p39, cJUN
Зовнішні ІД	OMIM: 165160 MGI: 96646 HomoloGene: 1679 GeneCards: JUN
Онтологія гена Молекулярна функція • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • cAMP response element binding • R-SMAD binding • HMG box domain binding • transcription factor binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • enzyme binding • chromatin binding • GO:0001948 protein binding • double-stranded DNA binding • DNA binding • sequence-specific DNA binding • GO:0001105 transcription coactivator activity • identical protein binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • RNA binding • protein homodimerization activity • protein heterodimerization activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • GO:0000975 transcription cis-regulatory region binding Клітинна компонента • гіалоплазма • transcription repressor complex • клітинне ядро • nuclear chromosome • Нуклеоплазма • transcription regulator complex • transcription factor AP-1 complex Біологічний процес • negative regulation of neuron apoptotic process • negative regulation of DNA binding • outflow tract morphogenesis • transcription by RNA polymerase II • Навчення • monocyte differentiation • response to organic substance • leading edge cell differentiation • Fc-epsilon receptor signaling pathway • positive regulation of neuron apoptotic process • cellular response to hormone stimulus • regulation of DNA-binding transcription factor activity • Циркадний ритм • Ангіогенез • positive regulation of ERK1 and ERK2 cascade • Ras protein signal transduction • transforming growth factor beta receptor signaling pathway • negative regulation of cell population proliferation • response to muscle stretch • cellular response to calcium ion • response to cytokine • regulation of transcription, DNA-templated • SMAD protein signal transduction • axon regeneration • positive regulation of fibroblast proliferation • response to mechanical stimulus • positive regulation of epithelial cell migration • positive regulation of DNA-templated transcription, initiation • transcription, DNA-templated • positive regulation of cell differentiation • positive regulation of monocyte differentiation • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of protein autophosphorylation • membrane depolarization • negative regulation of apoptotic process • eyelid development in camera-type eye • microglial cell activation • positive regulation of DNA replication • response to lipopolysaccharide • response to radiation • response to cAMP • negative regulation of transcription, DNA-templated • response to hydrogen peroxide • positive regulation of smooth muscle cell proliferation • positive regulation of endothelial cell proliferation • response to organic cyclic compound • Старіння людини • regulation of cell cycle • regulation of cell population proliferation • positive regulation of cell population proliferation • liver development • negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • cellular response to potassium ion starvation • cellular process • release of cytochrome c from mitochondria • positive regulation of transcription by RNA polymerase II • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • cellular response to reactive oxygen species • positive regulation of apoptotic process • positive regulation of transcription, DNA-templated • cellular response to cadmium ion • negative regulation of transcription by RNA polymerase II • positive regulation of vascular associated smooth muscle cell proliferation Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	3725	16476
Ensembl	ENSG00000177606	ENSMUSG00000052684
UniProt	P05412	P05627
RefSeq (мРНК)	NM_002228	NM_010591
RefSeq (білок)	NP_002219	NP_034721
Локус (UCSC)	Хр. 1: 58.78 – 58.78 Mb	Хр. 4: 95.05 – 95.05 Mb
PubMed search	[1]	[2]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Кодований геном білок за функцією належить до активаторів. Задіяний у таких біологічних процесах як транскрипція, регуляція транскрипції. Білок має сайт для зв'язування з ДНК. Локалізований у ядрі.