MACF1
MACF1 (англ. Microtubule-actin crosslinking factor 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. [2] Довжина поліпептидного ланцюга білка становить 7 388 амінокислот, а молекулярна маса — 838 308[3].
Послідовність амінокислот
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSSSDEETLS | ERSCRSERSC | RSERSYRSER | SGSLSPCPPG | DTLPWNLPLH | ||||
| EQKKRKSQDS | VLDPAERAVV | RVADERDRVQ | KKTFTKWVNK | HLMKVRKHIN | ||||
| DLYEDLRDGH | NLISLLEVLS | GIKLPREKGR | MRFHRLQNVQ | IALDFLKQRQ | ||||
| VKLVNIRNDD | ITDGNPKLTL | GLIWTIILHF | QISDIYISGE | SGDMSAKEKL | ||||
| LLWTQKVTAG | YTGIKCTNFS | SCWSDGKMFN | ALIHRYRPDL | VDMERVQIQS | ||||
| NRENLEQAFE | VAERLGVTRL | LDAEDVDVPS | PDEKSVITYV | SSIYDAFPKV | ||||
| PEGGEGISAT | EVDSRWQEYQ | SRVDSLIPWI | KQHTILMSDK | TFPQNPVELK | ||||
| ALYNQYIHFK | ETEILAKERE | KGRIEELYKL | LEVWIEFGRI | KLPQGYHPND | ||||
| VEEEWGKLII | EMLEREKSLR | PAVERLELLL | QIANKIQNGA | LNCEEKLTLA | ||||
| KNTLQADAAH | LESGQPVQCE | SDVIMYIQEC | EGLIRQLQVD | LQILRDENYY | ||||
| QLEELAFRVM | RLQDELVTLR | LECTNLYRKG | HFTSLELVPP | STLTTTHLKA | ||||
| EPLTKATHSS | STSWFRKPMT | RAELVAISSS | EDEGNLRFVY | ELLSWVEEMQ | ||||
| MKLERAEWGN | DLPSVELQLE | TQQHIHTSVE | ELGSSVKEAR | LYEGKMSQNF | ||||
| HTSYAETLGK | LETQYCKLKE | TSSFRMRHLQ | SLHKFVSRAT | AELIWLNEKE | ||||
| EEELAYDWSD | NNSNISAKRN | YFSELTMELE | EKQDVFRSLQ | DTAELLSLEN | ||||
| HPAKQTVEAY | SAAVQSQLQW | MKQLCLCVEQ | HVKENTAYFQ | FFSDARELES | ||||
| FLRNLQDSIK | RKYSCDHNTS | LSRLEDLLQD | SMDEKEQLIQ | SKSSVASLVG | ||||
| RSKTIVQLKP | RSPDHVLKNT | ISVKAVCDYR | QIEITICKND | ECVLEDNSQR | ||||
| TKWKVISPTG | NEAMVPSVCF | LIPPPNKDAI | EMASRVEQSY | QKVMALWHQL | ||||
| HVNTKSLISW | NYLRKDLDLV | QTWNLEKLRS | SAPGECHQIM | KNLQAHYEDF | ||||
| LQDSRDSVLF | SVADRLRLEE | EVEACKARFQ | HLMKSMENED | KEETVAKMYI | ||||
| SELKNIRLRL | EEYEQRVVKR | IQSLASSRTD | RDAWQDNALR | IAEQEHTQED | ||||
| LQQLRSDLDA | VSMKCDSFLH | QSPSSSSVPT | LRSELNLLVE | KMDHVYGLST | ||||
| VYLNKLKTVD | VIVRSIQDAE | LLVKGYEIKL | SQEEVVLADL | SALEAHWSTL | ||||
| RHWLSDVKDK | NSVFSVLDEE | IAKAKVVAEQ | MSRLTPERNL | DLERYQEKGS | ||||
| QLQERWHRVI | AQLEIRQSEL | ESIQEVLGDY | RACHGTLIKW | IEETTAQQEM | ||||
| MKPGQAEDSR | VLSEQLSQQT | ALFAEIERNQ | TKLDQCQKFS | QQYSTIVKDY | ||||
| ELQLMTYKAF | VESQQKSPGK | RRRMLSSSDA | ITQEFMDLRT | RYTALVTLTT | ||||
| QHVKYISDAL | RRLEEEEKVV | EEEKQEHVEK | VKELLGWVST | LARNTQGKAT | ||||
| SSETKESTDI | EKAILEQQVL | SEELTTKKEQ | VSEAIKTSQI | FLAKHGHKLS | ||||
| EKEKKQISEQ | LNALNKAYHD | LCDGSANQLQ | QLQSQLAHQT | EQKECRAVAG | ||||
| VIDLGTVEIF | PIFKAMQKGL | LDQDTGLVLL | ESQVIMSGLI | APETGENLSL | ||||
| EEGIARNLIN | PQMYQQLREL | QDALALISRL | TESRGPLSVV | EAIEKRIISE | ||||
| TVGLKILEAH | LATGGFSLSP | SENCINLEEA | FHQGLISAWL | HSVLESYLRT | ||||
| SKNLIDPNTA | EKIGLLDLMQ | RCIVHQESGF | KLLPVKQLAG | GMVSLKSGRK | ||||
| VSIFRAVQEG | LIDRQVTVRL | LEAQLFAGGI | VDPRTGHRLT | VEEAVRHNLI | ||||
| DQDMACAILI | RQLQTGGIID | TVTGQRLTID | EAVSNDLVAA | KIALVILESL | ||||
| WSFMGLLWPE | SGEILPITDA | LEQGIVSTEL | AHKILSNRQH | IKALFLPATT | ||||
| EILSWKKAIE | SGILDRDLAN | NLKSICIPDV | MPHMQLADSA | EQNINPGAAV | ||||
| LPCSKSHPKA | TASQSENLLF | QLMTHSYINV | QNGQRLLLLD | KELMETLTSR | ||||
| DEYQTSPPKV | VEIGHQRQKT | PEGLQESANV | KISGTFSSGW | TVRLPEFQFS | ||||
| SQNKEYPDRE | DCTTEKGKKT | TVETEDSSVE | NPEQDLFVEQ | KERNPNIDAL | ||||
| KVINKVKLEV | QRQLIGTQRE | DQTAVSVREN | ASRGHLLTIP | PAEAEGVPLV | ||||
| VDKDVFSVET | PKKEHQPLRN | TSFTCQNEQA | HTLETEYIHD | ETGGSHIKPQ | ||||
| SKKLQVQVKK | TLGIKLELKS | ETDGNVHPLD | KKEMLKKTFL | AKDDHKESQE | ||||
| AQNIAGGSMM | MSEKTDEEDS | GREIFLSCSH | PLELLEEATL | NVLSAQLLDG | ||||
| GIFHEQTGQK | LLLNEAISRG | IVPSHTAVKL | MEKLNMFQGF | FDSQTCESLT | ||||
| TEEVINEGLM | DEKLLHNVLM | ADKAISGVLD | PRTQTLCSVK | DAVTVGLLDK | ||||
| ETATRILERQ | VVTGGIIDLK | RGKKVSVTLA | STLGLVDVAD | QPELINLEKA | ||||
| SKGRDAEKTV | RERLISLQME | TTGLIDPDSK | APLTVVQSID | RGLLEREEAV | ||||
| RLLTKQVVDG | GIIHHISGMR | LSVDNAFRHG | LIGEDLAEKL | KRVENLNIHQ | ||||
| IFNPETKENI | SLPKAIKLDL | ITSDLKREIQ | EVQAFTGNFV | DLISGQRLTL | ||||
| AEAKKEGLLT | NEAVLSPGMM | HGIVDPENCR | IVPYSELVKK | CKIDIESGQR | ||||
| YLEVIPFSDI | KDGVSDKVLT | LSQAIQLGKV | DFASTLKVLE | AQANTGGIID | ||||
| TATGKRLTLA | SALEEKLVDE | NMVRIIASHQ | VLNGGIVDIF | SDQRVTLVEA | ||||
| IEKRLISPEL | ANMIQIDSSE | FSDHRAQIEK | QEGIEVCALQ | NEFLGKDMLI | ||||
| ACNQTAEMSC | NKVEESERLF | QVENQSAQEK | VKVRVSDGEQ | AKKSREISLK | ||||
| EFGCKDQRKP | RMSSDAKEFI | SIINPHNLKG | KSLGQVSLTH | PYSECDFKLK | ||||
| EVARNNMGND | TNEEQEKAVT | KIEIISHMKQ | STSCLDSEEI | RENQGEVILE | ||||
| VQETYCETSG | KLPSEQVLQQ | PMNARVKSKR | EKREVIVEES | IRTCKPAFLS | ||||
| EEKLYQETAI | RDEHDSHIKS | QPREMTSSEK | GKEADTEMGF | SITFKIEESS | ||||
| SQVVPQGISV | KHLDALTLFS | SKQANEGKVN | NLSLCLTLKP | EENLSREIAC | ||||
| GAQSEPFPCM | TPRPEGLHYQ | ESDGKAQVTG | PSQISKTDKS | FQGTTRQETN | ||||
| YQDSWVTSKT | KETKHQISSS | NECKEKSYQE | VSFDPARGLK | LEEITVSRPD | ||||
| SKEVRYLEFS | DRKDLHHQGS | KSDDKLCGTL | KSEIATQELT | GEKFLEMANP | ||||
| NVAGLEAGSI | EDIVTQRGSR | VLGSFLPEKL | FKGVSQKENT | GQQNAIISPT | ||||
| VLETSEEKTV | SLTVCSAVKT | EKTPQEKLRE | SPGSEQTPFM | TAPEGKGNGG | ||||
| VNPEPFRATQ | NVFTRQLCLE | HDEKLVSYLS | LLRNIEMRTK | QIQPLELNLA | ||||
| ELQDLLCQAK | VLERELKDLT | TLVSQELECV | NQIIISQPQE | VPAQLLKALE | ||||
| KDAKNLQKSL | SSVSDTWNSR | LLHFQNAVEI | EKTKVLNQHT | QLEGRLQDLR | ||||
| AWVGNKNLIL | NSKGSNSEID | VDSLNLCLQQ | YEDLKQPMAE | RKAQLDALAF | ||||
| DIQFFISEHA | QDLSPQQNRQ | MLRLLNELQR | SFQDILEQTA | AQVDALQGHL | ||||
| QQMEQEALVK | TLQKQQNTCH | QQLEDLCSWV | GQAERALAGH | QGRTTQQDLS | ||||
| ALQKNQSDLK | DLQDDIQNRA | TSFATVVKDI | EGFMEENQTK | LSPRELTALR | ||||
| EKLHQAKEQY | EALQEETRVA | QKELEEAVTS | ALQQETEKSK | AAKELAENKK | ||||
| KIDALLDWVT | SVGSSGGQLL | TNLPGMEQLS | GASLEKGALD | TTDGYMGVNQ | ||||
| APEKLDKQCE | MMKARHQELL | SQQQNFILAT | QSAQAFLDQH | GHNLTPEEQQ | ||||
| MLQQKLGELK | EQYSTSLAQS | EAELKQVQTL | QDELQKFLQD | HKEFESWLER | ||||
| SEKELENMHK | GGSSPETLPS | LLKRQGSFSE | DVISHKGDLR | FVTISGQKVL | ||||
| DMENSFKEGK | EPSEIGNLVK | DKLKDATERY | TALHSKCTRL | GSHLNMLLGQ | ||||
| YHQFQNSADS | LQAWMQACEA | NVEKLLSDTV | ASDPGVLQEQ | LATTKQLQEE | ||||
| LAEHQVPVEK | LQKVARDIME | IEGEPAPDHR | HVQETTDSIL | SHFQSLSYSL | ||||
| AERSSLLQKA | IAQSQSVQES | LESLLQSIGE | VEQNLEGKQV | SSLSSGVIQE | ||||
| ALATNMKLKQ | DIARQKSSLE | ATREMVTRFM | ETADSTTAAV | LQGKLAEVSQ | ||||
| RFEQLCLQQQ | EKESSLKKLL | PQAEMFEHLS | GKLQQFMENK | SRMLASGNQP | ||||
| DQDITHFFQQ | IQELNLEMED | QQENLDTLEH | LVTELSSCGF | ALDLCQHQDR | ||||
| VQNLRKDFTE | LQKTVKEREK | DASSCQEQLD | EFRKLVRTFQ | KWLKETEGSI | ||||
| PPTETSMSAK | ELEKQIEHLK | SLLDDWASKG | TLVEEINCKG | TSLENLIMEI | ||||
| TAPDSQGKTG | SILPSVGSSV | GSVNGYHTCK | DLTEIQCDMS | DVNLKYEKLG | ||||
| GVLHERQESL | QAILNRMEEV | HKEANSVLQW | LESKEEVLKS | MDAMSSPTKT | ||||
| ETVKAQAESN | KAFLAELEQN | SPKIQKVKEA | LAGLLVTYPN | SQEAENWKKI | ||||
| QEELNSRWER | ATEVTVARQR | QLEESASHLA | CFQAAESQLR | PWLMEKELMM | ||||
| GVLGPLSIDP | NMLNAQKQQV | QFMLKEFEAR | RQQHEQLNEA | AQGILTGPGD | ||||
| VSLSTSQVQK | ELQSINQKWV | ELTDKLNSRS | SQIDQAIVKS | TQYQELLQDL | ||||
| SEKVRAVGQR | LSVQSAISTQ | PEAVKQQLEE | TSEIRSDLEQ | LDHEVKEAQT | ||||
| LCDELSVLIG | EQYLKDELKK | RLETVALPLQ | GLEDLAADRI | NRLQAALAST | ||||
| QQFQQMFDEL | RTWLDDKQSQ | QAKNCPISAK | LERLQSQLQE | NEEFQKSLNQ | ||||
| HSGSYEVIVA | EGESLLLSVP | PGEEKRTLQN | QLVELKNHWE | ELSKKTADRQ | ||||
| SRLKDCMQKA | QKYQWHVEDL | VPWIEDCKAK | MSELRVTLDP | VQLESSLLRS | ||||
| KAMLNEVEKR | RSLLEILNSA | ADILINSSEA | DEDGIRDEKA | GINQNMDAVT | ||||
| EELQAKTGSL | EEMTQRLREF | QESFKNIEKK | VEGAKHQLEI | FDALGSQACS | ||||
| NKNLEKLRAQ | QEVLQALEPQ | VDYLRNFTQG | LVEDAPDGSD | ASQLLHQAEV | ||||
| AQQEFLEVKQ | RVNSGCVMME | NKLEGIGQFH | CRVREMFSQL | ADLDDELDGM | ||||
| GAIGRDTDSL | QSQIEDVRLF | LNKIHVLKLD | IEASEAECRH | MLEEEGTLDL | ||||
| LGLKRELEAL | NKQCGKLTER | GKARQEQLEL | TLGRVEDFYR | KLKGLNDATT | ||||
| AAEEAEALQW | VVGTEVEIIN | QQLADFKMFQ | KEQVDPLQMK | LQQVNGLGQG | ||||
| LIQSAGKDCD | VQGLEHDMEE | INARWNTLNK | KVAQRIAQLQ | EALLHCGKFQ | ||||
| DALEPLLSWL | ADTEELIANQ | KPPSAEYKVV | KAQIQEQKLL | QRLLDDRKAT | ||||
| VDMLQAEGGR | IAQSAELADR | EKITGQLESL | ESRWTELLSK | AAARQKQLED | ||||
| ILVLAKQFHE | TAEPISDFLS | VTEKKLANSE | PVGTQTAKIQ | QQIIRHKALN | ||||
| EEIVNRKKNV | DQAIKNGQAL | LKQTTGEEVL | LIQEKLDGIK | TRYADITVTS | ||||
| SKALRTLEQA | RQLATKFQST | YEELTGWLRE | VEEELATSGG | QSPTGEQIPQ | ||||
| FQQRQKELKK | EVMEHRLVLD | TVNEVSRALL | ELVPWRAREG | LDKLVSDANE | ||||
| QYKLVSDTIG | QRVDEIDAAI | QRSQQYEQAA | DAELAWVAET | KRKLMALGPI | ||||
| RLEQDQTTAQ | LQVQKAFSID | IIRHKDSMDE | LFSHRSEIFG | TCGEEQKTVL | ||||
| QEKTESLIQQ | YEAISLLNSE | RYARLERAQV | LVNQFWETYE | ELSPWIEETR | ||||
| ALIAQLPSPA | IDHEQLRQQQ | EEMRQLRESI | AEHKPHIDKL | LKIGPQLKEL | ||||
| NPEEGEMVEE | KYQKAENMYA | QIKEEVRQRA | LALDEAVSQS | TQITEFHDKI | ||||
| EPMLETLENL | SSRLRMPPLI | PAEVDKIREC | ISDNKSATVE | LEKLQPSFEA | ||||
| LKRRGEELIG | RSQGADKDLA | AKEIQDKLDQ | MVFFWEDIKA | RAEEREIKFL | ||||
| DVLELAEKFW | YDMAALLTTI | KDTQDIVHDL | ESPGIDPSII | KQQVEAAETI | ||||
| KEETDGLHEE | LEFIRILGAD | LIFACGETEK | PEVRKSIDEM | NNAWENLNKT | ||||
| WKERLEKLED | AMQAAVQYQD | TLQAMFDWLD | NTVIKLCTMP | PVGTDLNTVK | ||||
| DQLNEMKEFK | VEVYQQQIEM | EKLNHQGELM | LKKATDETDR | DIIREPLTEL | ||||
| KHLWENLGEK | IAHRQHKLEG | ALLALGQFQH | ALEELMSWLT | HTEELLDAQR | ||||
| PISGDPKVIE | VELAKHHVLK | NDVLAHQATV | ETVNKAGNEL | LESSAGDDAS | ||||
| SLRSRLEAMN | QCWESVLQKT | EEREQQLQST | LQQAQGFHSE | IEDFLLELTR | ||||
| MESQLSASKP | TGGLPETARE | QLDTHMELYS | QLKAKEETYN | QLLDKGRLML | ||||
| LSRDDSGSGS | KTEQSVALLE | QKWHVVSSKM | EERKSKLEEA | LNLATEFQNS | ||||
| LQEFINWLTL | AEQSLNIASP | PSLILNTVLS | QIEEHKVFAN | EVNAHRDQII | ||||
| ELDQTGNQLK | FLSQKQDVVL | IKNLLVSVQS | RWEKVVQRSI | ERGRSLDDAR | ||||
| KRAKQFHEAW | KKLIDWLEDA | ESHLDSELEI | SNDPDKIKLQ | LSKHKEFQKT | ||||
| LGGKQPVYDT | TIRTGRALKE | KTLLPEDSQK | LDNFLGEVRD | KWDTVCGKSV | ||||
| ERQHKLEEAL | LFSGQFMDAL | QALVDWLYKV | EPQLAEDQPV | HGDLDLVMNL | ||||
| MDAHKVFQKE | LGKRTGTVQV | LKRSGRELIE | NSRDDTTWVK | GQLQELSTRW | ||||
| DTVCKLSVSK | QSRLEQALKQ | AEVFRDTVHM | LLEWLSEAEQ | TLRFRGALPD | ||||
| DTEALQSLID | THKEFMKKVE | EKRVDVNSAV | AMGEVILAVC | HPDCITTIKH | ||||
| WITIIRARFE | EVLTWAKQHQ | QRLETALSEL | VANAELLEEL | LAWIQWAETT | ||||
| LIQRDQEPIP | QNIDRVKALI | AEHQTFMEEM | TRKQPDVDRV | TKTYKRKNIE | ||||
| PTHAPFIEKS | RSGGRKSLSQ | PTPPPMPILS | QSEAKNPRIN | QLSARWQQVW | ||||
| LLALERQRKL | NDALDRLEEL | KEFANFDFDV | WRKKYMRWMN | HKKSRVMDFF | ||||
| RRIDKDQDGK | ITRQEFIDGI | LASKFPTTKL | EMTAVADIFD | RDGDGYIDYY | ||||
| EFVAALHPNK | DAYRPTTDAD | KIEDEVTRQV | AQCKCAKRFQ | VEQIGENKYR | ||||
| FGDSQQLRLV | RILRSTVMVR | VGGGWMALDE | FLVKNDPCRA | RGRTNIELRE | ||||
| KFILPEGASQ | GMTPFRSRGR | RSKPSSRAAS | PTRSSSSASQ | SNHSCTSMPS | ||||
| SPATPASGTK | VIPSSGSKLK | RPTPTFHSSR | TSLAGDTSNS | SSPASTGAKT | ||||
| NRADPKKSAS | RPGSRAGSRA | GSRASSRRGS | DASDFDLLET | QSACSDTSES | ||||
| SAAGGQGNSR | RGLNKPSKIP | TMSKKTTTAS | PRTPGPKR |
Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у таких біологічних процесах як сигнальний шлях Wnt, поліморфізм, ацетиляція, альтернативний сплайсинг. Білок має сайт для зв'язування з молекулою актину, іонами металів, іоном кальцію. Локалізований у клітинній мембрані, цитоплазмі, цитоскелеті, мембрані, клітинних відростках, апараті гольджі.
Література
- Gong T.-W.L., Besirli C.G., Lomax M.I. (2001). MACF1 gene structure: a hybrid of plectin and dystrophin.. Mamm. Genome 12: 852 — 861. PubMed DOI:10.1007/s00335-001-3037-3
- Kakinuma T., Ichikawa H., Tsukada Y., Nakamura T., Toh B.H. (2004). Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery.. Exp. Cell Res. 298: 388 — 398. PubMed DOI:10.1016/j.yexcr.2004.04.047
- Lin C.-M., Chen H.-J., Leung C.L., Parry D.A.D., Liem R.K.H. (2005). Microtubule actin crosslinking factor 1b: a novel plakin that localizes to the Golgi complex.. J. Cell Sci. 118: 3727 — 3738. PubMed DOI:10.1242/jcs.02510
- Zaoui K., Benseddik K., Daou P., Salaun D., Badache A. (2010). ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.. Proc. Natl. Acad. Sci. U.S.A. 107: 18517 — 18522. PubMed DOI:10.1073/pnas.1000975107
Примітки
- Human PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:13664 (англ.). Процитовано 28 серпня 2017.
- UniProt, Q9UPN3 (англ.). Процитовано 28 серпня 2017.
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