MUC5B
MUC5B (англ. Mucin 5B, oligomeric mucus/gel-forming) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 5 762 амінокислот, а молекулярна маса — 596 340[4].
Послідовність амінокислот
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MGAPSACRTL | VLALAAMLVV | PQAETQGPVE | PSWENAGHTM | DGGAPTSSPT | ||||
| RRVSFVPPVT | VFPSLSPLNP | AHNGRVCSTW | GDFHYKTFDG | DVFRFPGLCN | ||||
| YVFSEHCRAA | YEDFNVQLRR | GLVGSRPVVT | RVVIKAQGLV | LEASNGSVLI | ||||
| NGQREELPYS | RTGLLVEQSG | DYIKVSIRLV | LTFLWNGEDS | ALLELDPKYA | ||||
| NQTCGLCGDF | NGLPAFNEFY | AHNARLTPLQ | FGNLQKLDGP | TEQCPDPLPL | ||||
| PAGNCTDEEG | ICHRTLLGPA | FAECHALVDS | TAYLAACAQD | LCRCPTCPCA | ||||
| TFVEYSRQCA | HAGGQPRNWR | CPELCPRTCP | LNMQHQECGS | PCTDTCSNPQ | ||||
| RAQLCEDHCV | DGCFCPPGTV | LDDITHSGCL | PLGQCPCTHG | GRTYSPGTSF | ||||
| NTTCSSCTCS | GGLWQCQDLP | CPGTCSVQGG | AHISTYDEKL | YDLHGDCSYV | ||||
| LSKKCADSSF | TVLAELRKCG | LTDNENCLKA | VTLSLDGGDT | AIRVQADGGV | ||||
| FLNSIYTQLP | LSAANITLFT | PSSFFIVVQT | GLGLQLLVQL | VPLMQVFVRL | ||||
| DPAHQGQMCG | LCGNFNQNQA | DDFTALSGVV | EATGAAFANT | WKAQAACANA | ||||
| RNSFEDPCSL | SVENENYARH | WCSRLTDPNS | AFSRCHSIIN | PKPFHSNCMF | ||||
| DTCNCERSED | CLCAALSSYV | HACAAKGVQL | SDWRDGVCTK | YMQNCPKSQR | ||||
| YAYVVDACQP | TCRGLSEADV | TCSVSFVPVD | GCTCPAGTFL | NDAGACVPAQ | ||||
| ECPCYAHGTV | LAPGEVVHDE | GAVCSCTGGK | LSCLGASLQK | STGCAAPMVY | ||||
| LDCSNSSAGT | PGAECLRSCH | TLDVGCFSTH | CVSGCVCPPG | LVSDGSGGCI | ||||
| AEEDCPCVHN | EATYKPGETI | RVDCNTCTCR | NRRWECSHRL | CLGTCVAYGD | ||||
| GHFITFDGDR | YSFEGSCEYI | LAQDYCGDNT | THGTFRIVTE | NIPCGTTGTT | ||||
| CSKAIKLFVE | SYELILQEGT | FKAVARGPGG | DPPYKIRYMG | IFLVIETHGM | ||||
| AVSWDRKTSV | FIRLHQDYKG | RVCGLCGNFD | DNAINDFATR | SRSVVGDALE | ||||
| FGNSWKLSPS | CPDALAPKDP | CTANPFRKSW | AQKQCSILHG | PTFAACRSQV | ||||
| DSTKYYEACV | NDACACDSGG | DCECFCTAVA | AYAQACHDAG | LCVSWRTPDT | ||||
| CPLFCDFYNP | HGGCEWHYQP | CGAPCLKTCR | NPSGHCLVDL | PGLEGCYPKC | ||||
| PPSQPFFNED | QMKCVAQCGC | YDKDGNYYDV | GARVPTAENC | QSCNCTPSGI | ||||
| QCAHSLEACT | CTYEDRTYSY | QDVIYNTTDG | LGACLIAICG | SNGTIIRKAV | ||||
| ACPGTPATTP | FTFTTAWVPH | STTSPALPVS | TVCVREVCRW | SSWYNGHRPE | ||||
| PGLGGGDFET | FENLRQRGYQ | VCPVLADIEC | RAAQLPDMPL | EELGQQVDCD | ||||
| RMRGLMCANS | QQSPPLCHDY | ELRVLCCEYV | PCGPSPAPGT | SPQPSLSAST | ||||
| EPAVPTPTQT | TATEKTTLWV | TPSIRSTAAL | TSQTGSSSGP | VTVTPSAPGT | ||||
| TTCQPRCQWT | EWFDEDYPKS | EQLGGDVESY | DKIRAAGGHL | CQQPKDIECQ | ||||
| AESFPNWTLA | QVGQKVHCDV | HFGLVCRNWE | QEGVFKMCYN | YRIRVLCCSD | ||||
| DHCRGRATTP | PPTTELETAT | TTTTQALFST | PQPTSSPGLT | RAPPASTTAV | ||||
| PTLSEGLTSP | RYTSTLGTAT | TGGPTTPAGS | TEPTVPGVAT | STLPTRSALP | ||||
| GTTGSLGTWR | PSQPPTLAPT | TMATSRARPT | GTASTASKEP | LTTSLAPTLT | ||||
| SELSTSQAET | STPRTETTMS | PLTNTTTSQG | TTRCQPKCEW | TEWFDVDFPT | ||||
| SGVAGGDMET | FENIRAAGGK | MCWAPKSIEC | RAENYPEVSI | DQVGQVLTCS | ||||
| LETGLTCKNE | DQTGRFNMCF | NYNVRVLCCD | DYSHCPSTPA | TSSTATPSST | ||||
| PGTTWILTKP | TTTATTTAST | GSTATPTSTL | RTAPPPKVLT | TTATTPTVTS | ||||
| SKATPSSSPG | TATALPALRS | TATTPTATSV | TPIPSSSLGT | TWTRLSQTTT | ||||
| PTATMSTATP | SSTPETAHTS | TVLTATATTT | GATGSVATPS | STPGTAHTTK | ||||
| VPTTTTTGFT | ATPSSSPGTA | LTPPVWISTT | TTPTTRGSTV | TPSSIPGTTH | ||||
| TATVLTTTTT | TVATGSMATP | SSSTQTSGTP | PSLTTTATTI | TATGSTTNPS | ||||
| STPGTTPIPP | VLTTTATTPA | ATSNTVTPSS | ALGTTHTPPV | PNTMATTHGR | ||||
| SLPPSSPHTV | RTAWTSATSG | ILGTTHITEP | STVTSHTLAA | TTGTTQHSTP | ||||
| ALSSPHPSSR | TTESPPSPGT | TTPGHTTATS | RTTATATPSK | TRTSTLLPSS | ||||
| PTSAPITTVV | TMGCEPQCAW | SEWLDYSYPM | PGPSGGDFDT | YSNIRAAGGA | ||||
| VCEQPLGLEC | RAQAQPGVPL | RELGQVVECS | LDFGLVCRNR | EQVGKFKMCF | ||||
| NYEIRVFCCN | YGHCPSTPAT | SSTAMPSSTP | GTTWILTELT | TTATTTESTG | ||||
| STATPSSTPG | TTWILTEPST | TATVTVPTGS | TATASSTQAT | AGTPHVSTTA | ||||
| TTPTVTSSKA | TPFSSPGTAT | ALPALRSTAT | TPTATSFTAI | PSSSLGTTWT | ||||
| RLSQTTTPTA | TMSTATPSST | PETVHTSTVL | TTTATTTGAT | GSVATPSSTP | ||||
| GTAHTTKVLT | TTTTGFTATP | SSSPGTARTL | PVWISTTTTP | TTRGSTVTPS | ||||
| SIPGTTHTPT | VLTTTTTTVA | TGSMATPSSS | TQTSGTPPSL | TTTATTITAT | ||||
| GSTTNPSSTP | GTTPIPPVLT | TTATTPAATS | STVTPSSALG | TTHTPPVPNT | ||||
| TATTHGRSLS | PSSPHTVRTA | WTSATSGTLG | TTHITEPSTG | TSHTPAATTG | ||||
| TTQHSTPALS | SPHPSSRTTE | SPPSPGTTTP | GHTRATSRTT | ATATPSKTRT | ||||
| STLLPSSPTS | APITTVVTMG | CEPQCAWSEW | LDYSYPMPGP | SGGDFDTYSN | ||||
| IRAAGGAVCE | QPLGLECRAQ | AQPGVPLREL | GQVVECSLDF | GLVCRNREQV | ||||
| GKFKMCFNYE | IRVFCCNYGH | CPSTPATSST | ATPSSTPGTT | WILTEQTTAA | ||||
| TTTATTGSTA | IPSSTPGTAP | PPKVLTSTAT | TPTATSSKAT | SSSSPRTATT | ||||
| LPVLTSTATK | STATSFTPIP | SFTLGTTGTL | PEQTTTPMAT | MSTIHPSSTP | ||||
| ETTHTSTVLT | TKATTTRATS | SMSTPSSTPG | TTWILTELTT | AATTTAATGP | ||||
| TATPSSTPGT | TWILTEPSTT | ATVTVPTGST | ATASSTRATA | GTLKVLTSTA | ||||
| TTPTVISSRA | TPSSSPGTAT | ALPALRSTAT | TPTATSVTAI | PSSSLGTAWT | ||||
| RLSQTTTPTA | TMSTATPSST | PETVHTSTVL | TTTTTTTRAT | GSVATPSSTP | ||||
| GTAHTTKVPT | TTTTGFTATP | SSSPGTALTP | PVWISTTTTP | TTRGSTVTPS | ||||
| SIPGTTHTAT | VLTTTTTTVA | TGSMATPSSS | TQTSGTPPSL | TTTATTITAT | ||||
| GSTTNPSSTP | GTTPIPPVLT | TTATTPAATS | STVTPSSALG | TTHTPPVPNT | ||||
| TATTHGRSLP | PSSPHTVRTA | WTSATSGILG | TTHITEPSTV | TSHTPAATTS | ||||
| TTQHSTPALS | SPHPSSRTTE | SPPSPGTTTP | GHTRGTSRTT | ATATPSKTRT | ||||
| STLLPSSPTS | APITTVVTTG | CEPQCAWSEW | LDYSYPMPGP | SGGDFDTYSN | ||||
| IRAAGGAVCE | QPLGLECRAQ | AQPGVPLREL | GQVVECSLDF | GLVCRNREQV | ||||
| GKFKMCFNYE | IRVFCCNYGH | CPSTPATSST | ATPSSTPGTT | WILTKLTTTA | ||||
| TTTESTGSTA | TPSSTPGTTW | ILTEPSTTAT | VTVPTGSTAT | ASSTQATAGT | ||||
| PHVSTTATTP | TVTSSKATPF | SSPGTATALP | ALRSTATTPT | ATSFTAIPSS | ||||
| SLGTTWTRLS | QTTTPTATMS | TATPSSTPET | AHTSTVLTTT | ATTTRATGSV | ||||
| ATPSSTPGTA | HTTKVPTTTT | TGFTVTPSSS | PGTARTPPVW | ISTTTTPTTS | ||||
| GSTVTPSSVP | GTTHTPTVLT | TTTTTVATGS | MATPSSSTQT | SGTPPSLITT | ||||
| ATTITATGST | TNPSSTPGTT | PIPPVLTTTA | TTPAATSSTV | TPSSALGTTH | ||||
| TPPVPNTTAT | THGRSLSPSS | PHTVRTAWTS | ATSGTLGTTH | ITEPSTGTSH | ||||
| TPAATTGTTQ | HSTPALSSPH | PSSRTTESPP | SPGTTTPGHT | TATSRTTATA | ||||
| TPSKTRTSTL | LPSSPTSAPI | TTVVTTGCEP | QCAWSEWLDY | SYPMPGPSGG | ||||
| DFDTYSNIRA | AGGAVCEQPL | GLECRAQAQP | GVPLGELGQV | VECSLDFGLV | ||||
| CRNREQVGKF | KMCFNYEIRV | FCCNYGHCPS | TPATSSTAMP | SSTPGTTWIL | ||||
| TELTTTATTT | ASTGSTATPS | STPGTAPPPK | VLTSPATTPT | ATSSKATSSS | ||||
| SPRTATTLPV | LTSTATKSTA | TSVTPIPSST | LGTTGTLPEQ | TTTPVATMST | ||||
| IHPSSTPETT | HTSTVLTTKA | TTTRATSSTS | TPSSTPGTTW | ILTELTTAAT | ||||
| TTAATGPTAT | PSSTPGTTWI | LTELTTTATT | TASTGSTATP | SSTPGTTWIL | ||||
| TEPSTTATVT | VPTGSTATAS | STQATAGTPH | VSTTATTPTV | TSSKATPSSS | ||||
| PGTATALPAL | RSTATTPTAT | SFTAIPSSSL | GTTWTRLSQT | TTPTATMSTA | ||||
| TPSSTPETVH | TSTVLTATAT | TTGATGSVAT | PSSTPGTAHT | TKVPTTTTTG | ||||
| FTATPSSSPG | TALTPPVWIS | TTTTPTTTTP | TTSGSTVTPS | SIPGTTHTAR | ||||
| VLTTTTTTVA | TGSMATPSSS | TQTSGTPPSL | TTTATTITAT | GSTTNPSSTP | ||||
| GTTPITPVLT | STATTPAATS | SKATSSSSPR | TATTLPVLTS | TATKSTATSF | ||||
| TPIPSSTLWT | TWTVPAQTTT | PMSTMSTIHT | SSTPETTHTS | TVLTTTATMT | ||||
| RATNSTATPS | STLGTTRILT | ELTTTATTTA | ATGSTATLSS | TPGTTWILTE | ||||
| PSTIATVMVP | TGSTATASST | LGTAHTPKVV | TTMATMPTAT | ASTVPSSSTV | ||||
| GTTRTPAVLP | SSLPTFSVST | VSSSVLTTLR | PTGFPSSHFS | TPCFCRAFGQ | ||||
| FFSPGEVIYN | KTDRAGCHFY | AVCNQHCDID | RFQGACPTSP | PPVSSAPLSS | ||||
| PSPAPGCDNA | IPLRQVNETW | TLENCTVARC | VGDNRVVLLD | PKPVANVTCV | ||||
| NKHLPIKVSD | PSQPCDFHYE | CECICSMWGG | SHYSTFDGTS | YTFRGNCTYV | ||||
| LMREIHARFG | NLSLYLDNHY | CTASATAAAA | RCPRALSIHY | KSMDIVLTVT | ||||
| MVHGKEEGLI | LFDQIPVSSG | FSKNGVLVSV | LGTTTMRVDI | PALGVSVTFN | ||||
| GQVFQARLPY | SLFHNNTEGQ | CGTCTNNQRD | DCLQRDGTTA | ASCKDMAKTW | ||||
| LVPDSRKDGC | WAPTGTPPTA | SPAAPVSSTP | TPTPCPPQPL | CDLMLSQVFA | ||||
| ECHNLVPPGP | FFNACISDHC | RGRLEVPCQS | LEAYAELCRA | RGVCSDWRGA | ||||
| TGGLCDLTCP | PTKVYKPCGP | IQPATCNSRN | QSPQLEGMAE | GCFCPEDQIL | ||||
| FNAHMGICVQ | ACPCVGPDGF | PKFPGERWVS | NCQSCVCDEG | SVSVQCKPLP | ||||
| CDAQGQPPPC | NRPGFVTVTR | PRAENPCCPE | TVCVCNTTTC | PQSLPVCPPG | ||||
| QESICTQEEG | DCCPTFRCRP | QLCSYNGTFY | GVGATFPGAL | PCHMCTCLSG | ||||
| DTQDPTVQCQ | EDACNNTTCP | QGFEYKRVAG | QCCGECVQTA | CLTPDGQPVQ | ||||
| LNETWVNSHV | DNCTVYLCEA | EGGVHLLTPQ | PASCPDVSSC | RGSLRKTGCC | ||||
| YSCEEDSCQV | RINTTILWHQ | GCETEVNITF | CEGSCPGASK | YSAEAQAMQH | ||||
| QCTCCQERRV | HEETVPLHCP | NGSAILHTYT | HVDECGCTPF | CVPAPMAPPH | ||||
| TRGFPAQEAT | AV |
| MUC5B | |||||||||||||||||
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| Ідентифікатори | |||||||||||||||||
| Символи | MUC5B, MG1, MUC-5B, MUC5, MUC9, mucin 5B, oligomeric mucus/gel-forming | ||||||||||||||||
| Зовнішні ІД | OMIM: 600770 MGI: 1921430 HomoloGene: 136756 GeneCards: MUC5B | ||||||||||||||||
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| Види | Людина | Миша | |||||||||||||||
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| RefSeq (білок) |
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| Локус (UCSC) | Хр. 11: 1.22 – 1.26 Mb | Хр. 7: 141.84 – 141.87 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
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Секретований назовні.
Література
- Chen Y., Zhao Y.H., Di Y.P., Wu R. (2001). Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region.. Am. J. Respir. Cell Mol. Biol. 25: 542 — 553. PubMed DOI:10.1165/ajrcmb.25.5.4298
- Offner G.D., Nunes D.P., Keates A.C., Afdhal N.H., Troxler R.F. (1998). The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions.. Biochem. Biophys. Res. Commun. 251: 350 — 355. PubMed DOI:10.1006/bbrc.1998.9469
- Desseyn J.-L., Buisine M.P., Porchet N., Aubert J.-P., Laine A. (1998). Genomic organization of the human mucin gene MUC5B: cDNA and genomic sequences upstream of the large central exon.. J. Biol. Chem. 273: 30157 — 30164. PubMed DOI:10.1074/jbc.273.46.30157
- Desseyn J.-L., Guyonnet-Duperat V., Porchet N., Aubert J.-P., Laine A. (1997). Human mucin gene MUC5B, the 10.7 kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family.. J. Biol. Chem. 272: 3168 — 3178. PubMed DOI:10.1074/jbc.272.6.3168
- Keates A.C., Nunes D.P., Afdhal N.H., Troxler R.F., Offner G.D. (1997). Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B.. Biochem. J. 324: 295 — 303. PubMed DOI:10.1042/bj3240295
- Troxler R.F., Offner G.D., Zhang F., Iontcheva I., Oppenheim F.G. (1995). Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland.. Biochem. Biophys. Res. Commun. 217: 1112 — 1119. PubMed DOI:10.1006/bbrc.1995.2884
Примітки
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:7516 (англ.). Процитовано 8 вересня 2017.
- UniProt, Q9HC84 (англ.). Процитовано 8 вересня 2017.
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