OBSCN

OBSCN (англ. Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. [3] Довжина поліпептидного ланцюга білка становить 7 968 амінокислот, а молекулярна маса — 868 484[4].

Послідовність амінокислот
1020304050
MDQPQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPV
AAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVD
AEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRL
GEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALV
VDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVT
EGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILF
CKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESA
TFLCEVPQPSTEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDA
VYICETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGP
VHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTS
TQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGERPVTIDGYLV
EKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPY
LEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVASAGEWFLDGQA
LKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAA
PGLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTLSPGP
KYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHK
DMAGSCVDAVAGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVG
TRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKVVFAKEQLARRKL
QAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQ
QAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASA
TLSCEVAQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAG
DYSCEARGQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQ
AQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGG
QRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEVTWY
KDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLH
ITEPKAVFAKEQLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSS
SSKVRIEAAGCMRQLVVQQAGQADAGEYTCEAGGQRLSFHLDVSEPKAVF
AKEQLAHRKVQAEAGAIATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEA
VGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQPVHR
EVQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLV
VQQAGQAVAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEAGT
SATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQAD
AGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEV
AQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQAEAGEYSCEA
GGQQLSFRLQVAELEPQISERPCRREPLVVKEHEDIILTATLATPSAATV
TWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCRVGAEGQDF
PVQVEEVAAKFCRLLEPVCGELGGTVTLACELSPACAEVVWRCGNTQLRV
GKRFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVK
FMSGLSTVVAEEGGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAISQSG
ASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKLEPQTVE
ERSSVTLEVELTRPWPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVG
FADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQL
SHADVDGSWTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKA
EGVHTSARLVVTELPVSFSRPLQDVVTTEKEKVTLECELSRPNVDVRWLK
DGVELRAGKTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKV
QGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLRVKELPVTLVRPLRDKI
AMEKHRGVLECQVSRASAQVRWFKGSQELQPGPKYELVSDGLYRKLIISD
VHAEDEDTYTCDAGDVKTSAQFFVEEQSITIVRGLQDVTVMEPAPAWFEC
ETSIPSVRPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPVH
FTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQSVVLSCDFRPAPKAVQ
WYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSSTE
VTVEAREVTVTGPLQDAEATEEGWASFSCELSHEDEEVEWSLNGMPLYND
SFHEISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKPVVFL
KALDDLSAEERGTLALQCEVSDPEAHVVWRKDGVQLGPSDKYDFLHTAGT
RGLVVHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKTMEVLEG
ESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVREAA
PSDAGEVVFSVRGLTSKASLIVRERPAAIIKPLEDQWVAPGEDVELRCEL
SRAGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEV
EASKSTASLHVEEKANCFTEELTNLQVEEKGTAVFTCKTEHPAATVTWRK
GLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTCDIGQAQSRAQLLV
QGRRVHIIEDLEDVDVQEGSSATFRCRISPANYEPVHWFLDKTPLHANEL
NEIDAQPGGYHVLTLRQLALKDSGTIYFEAGDQRASAALRVTEKPSVFSR
ELTDATITEGEDLTLVCETSTCDIPVCWTKDGKTLRGSARCQLSHEGHRA
QLLITGATLQDSGRYKCEAGGACSSSIVRVHARPVRFQEALKDLEVLEGG
AATLRCVLSSVAAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQD
SGRYSCSFGDQTTSATLTVTALPAQFIGKLRNKEATEGATATLRCELSKA
APVEWRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEER
TSASLTIRPMPAHFIGRLRHQESIEGATATLRCELSKAAPVEWRKGRESL
RDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCGEERTSATLTVKALPA
KFTEGLRNEEAVEGATAMLWCELSKVAPVEWRKGPENLRDGDRYILRQEG
TRCELQICGLAMADAGEYLCVCGQERTSATLTIRALPARFIEDVKNQEAR
EGATAVLQCELNSAAPVEWRKGSETLRDGDRYSLRQDGTKCELQIRGLAM
ADTGEYSCVCGQERTSAMLTVRALPIKFTEGLRNEEATEGATAVLRCELS
KMAPVEWWKGHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEYLCMCGK
ERTSAMLTVRAMPSKFIEGLRNEEATEGDTATLWCELSKAAPVEWRKGHE
TLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTSATLTVRAL
PARFIEDVKNQEAREGATAVLQCELSKAAPVEWRKGSETLRGGDRYSLRQ
DGTRCELQIHGLSVADTGEYSCVCGQERTSATLTVRAPQPVFREPLQSLQ
AEEGSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQD
LQREDTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCC
ELSRAGASVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTC
DTGHTQSMASLSVRVPRPKFKTRLQSLEQETGDIARLCCQLSDAESGAVV
QWLKEGVELHAGPKYEMRSQGATRELLIHQLEAKDTGEYACVTGGQKTAA
SLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGLPLQ
SNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQLTVRAPEV
TILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITV
EQGTLHLLTLHKVTLEDAGTVSFHVGTCSSEAQLKVTAKNTVVRGLENVE
ALEGGEALFECQLSQPEVAAHTWLLDDEPVHTSENAEVVFFENGLRHLLL
LKNLRPQDSCRVTFLAGDMVTSAFLTVRGWRLEILEPLKNAAVRAGAQAC
FTCTLSEAVPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQPHH
AGEVTFACRDAVASARLTVLGLPDPPEDAEVVARSSHTVTLSWAAPMSDG
GGGLCGYRVEVKEGATGQWRLCHELVPGPECVVDGLAPGETYRFRVAAVG
PVGAGEPVHLPQTVRLAEPPKPVPPQPSAPESRQVAAGEDVSLELEVVAE
AGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAEDQGEYHCGLAQG
SICPAAATFQVALSPASVDEAPQPSLPPEAAQEGDLHLLWEALARKRRMS
REPTLDSISELPEEDGRSQRLPQEAEEVAPDLSEGYSTADELARTGDADL
SHTSSDDESRAGTPSLVTYLKKAGRPGTSPLASKVGAPAAPSVKPQQQQE
PLAAVRPPLGDLSTKDLGDPSMDKAAVKIQAAFKGYKVRKEMKQQEGPMF
SHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLG
DGTCSLLITGLDRADAGCYTCQVSNKFGQVTHSACVVVSGSESEAESSSG
GELDDAFRRAARRLHRLFRTKSPAEVSDEELFLSADEGPAEPEEPADWQT
YREDEHFICIRFEALTEARQAVTRFQEMFATLGIGVEIKLVEQGPRRVEM
CISKETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVT
GQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCL
AENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGT
ESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQP
LTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLV
RGPDEPEEKPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVP
TVHWLREEAERGVLWIGPDTPGYTVASSAQQHSLVLLDVGRQHQGTYTCI
ASNAAGQALCSASLHVSGLPKVEEQEKVKEALISTFLQGTTQAISAQGLE
TASFADLGGQRKEEPLAAKEALGHLSLAEVGTEEFLQKLTSQITEMVSAK
ITQAKLQVPGGDSDEDSKTPSASPRHGRSRPSSSIQESSSESEDGDARGE
IFDIYVVTADYLPLGAEQDAITLREGQYVEVLDAAHPLRWLVRTKPTKSS
PSRQGWVSPAYLDRRLKLSPEWGAAEAPEFPGEAVSEDEYKARLSSVIQE
LLSSEQAFVEELQFLQSHHLQHLERCPHVPIAVAGQKAVIFRNVRDIGRF
HSSFLQELQQCDTDDDVAMCFIKNQAAFEQYLEFLVGRVQAESVVVSTAI
QEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKELIRNK
ARNRQNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQG
HFIVWEGAPGARMPWKGHNRHVFLFRNHLVICKPRRDSRTDTVSYVFRNM
MKLSSIDLNDQVEGDDRAFEVWQEREDSVRKYLLQARTAIIKSSWVKEIC
GIQQRLALPVWRPPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKD
GKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLG
KILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTT
GNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRIQ
SPMLQAQEQCHREQLVAAVEDTTLERADQEVTSVLKRLLGPKAPGPSTGD
LTGPGPCPRGAPALQETGSQPPVTGTSEAPAVPPRVPQPLLHEGPEQEPE
AIARAQEWTVPIRMEGAAWPGAGTGELLWDVHSHVVRETTQRTYTYQAID
THTARPPSMQVTIEDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLVDS
TRLSQQQEGTTYSLVLRHVASKDAGVYTCLAQNTGGQVLCKAELLVLGGD
NEPDSEKQSHRRKLHSFYEVKEEIGRGVFGFVKRVQHKGNKILCAAKFIP
LRSRTRAQAYRERDILAALSHPLVTGLLDQFETRKTLILILELCSSEELL
DRLYRKGVVTEAEVKVYIQQLVEGLHYLHSHGVLHLDIKPSNILMVHPAR
EDIKICDFGFAQNITPAELQFSQYGSPEFVSPEIIQQNPVSEASDIWAMG
VISYLSLTCSSPFAGESDRATLLNVLEGRVSWSSPMAAHLSEDAKDFIKA
TLQRAPQARPSAAQCLSHPWFLKSMPAEEAHFINTKQLKFLLARSRWQRS
LMSYKSILVMRSIPELLRGPPDSPSLGVARHLCRDTGGSSSSSSSSDNEL
APFARAKSLPPSPVTHSPLLHPRGFLRPSASLPEEAEASERSTEAPAPPA
SPEGAGPPAAQGCVPRHSVIRSLFYHQAGESPEHGALAPGSRRHPARRRH
LLKGGYIAGALPGLREPLMEHRVLEEEAAREEQATLLAKAPSFETALRLP
ASGTHLAPGHSHSLEHDSPSTPRPSSEACGEAQRLPSAPSGGAPIRDMGH
PQGSKQLPSTGGHPGTAQPERPSPDSPWGQPAPFCHPKQGSAPQEGCSPH
PAVAPCPPGSFPPGSCKEAPLVPSSPFLGQPQAPPAPAKASPPLDSKMGP
GDISLPGRPKPGPCSSPGSASQASSSQVSSLRVGSSQVGTEPGPSLDAEG
WTQEAEDLSDSTPTLQRPQEQATMRKFSLGGRGGYAGVAGYGTFAFGGDA
GGMLGQGPMWARIAWAVSQSEEEEQEEARAESQSEEQQEARAESPLPQVS
ARPVPEVGRAPTRSSPEPTPWEDIGQVSLVQIRDLSGDAEAADTISLDIS
EVDPAYLNLSDLYDIKYLPFEFMIFRKVPKSAQPEPPSPMAEEELAEFPE
PTWPWPGELGPHAGLEITEESEDVDALLAEAAVGRKRKWSSPSRSLFHFP
GRHLPLDEPAELGLRERVKASVEHISRILKGRPEGLEKEGPPRKKPGLAS
FRLSGLKSWDRAPTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDG
APLESSSRVLISATLKNFQLLTILVVVAEDLGVYTCSVSNALGTVTTTGV
LRKAERPSSSPCPDIGEVYADGVLLVWKPVESYGPVTYIVQCSLEGGSWT
TLASDIFDCCYLTSKLSRGGTYTFRTACVSKAGMGPYSSPSEQVLLGGPS
HLASEEESQGRSAQPLPSTKTFAFQTQIQRGRFSVVRQCWEKASGRALAA
KIIPYHPKDKTAVLREYEALKGLRHPHLAQLHAAYLSPRHLVLILELCSG
PELLPCLAERASYSESEVKDYLWQMLSATQYLHNQHILHLDLRSENMIIT
EYNLLKVVDLGNAQSLSQEKVLPSDKFKDYLETMAPELLEGQGAVPQTDI
WAIGVTAFIMLSAEYPVSSEGARDLQRGLRKGLVRLSRCYAGLSGGAVAF
LRSTLCAQPWGRPCASSCLQCPWLTEEGPACSRPAPVTFPTARLRVFVRN
REKRRALLYKRHNLAQVR
OBSCN
Наявні структури
PDBПошук ортологів: PDBe RCSB
Ідентифікатори
Символи OBSCN, ARHGEF30, UNC89, obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Зовнішні ІД OMIM: 608616 MGI: 2681862 HomoloGene: 70869 GeneCards: OBSCN
Ортологи
Види Людина Миша
Entrez
84033
380698
Ensembl
ENSG00000154358
ENSMUSG00000061462
UniProt
Q5VST9
A2AAJ9
RefSeq (мРНК)
NM_001098623
NM_001271223
NM_052843
NM_001386125
NM_001171512
NM_199152
RefSeq (білок)
NP_001092093
NP_001258152
NP_443075
NP_001164983
NP_954603
Локус (UCSC) Хр. 1: 228.21 – 228.38 Mb Хр. 11: 58.99 – 59.14 Mb
PubMed search [1] [2]
Вікідані
Див./Ред. для людейДив./Ред. для мишей

Кодований геном білок за функціями належить до трансфераз, кіназ, cерин/треонінових протеїнкіназ, м'язових білків, білків розвитку, фосфопротеїнів. Задіяний у таких біологічних процесах як диференціація, поліморфізм, альтернативний сплайсинг. Білок має сайт для зв'язування з АТФ, нуклеотидами, молекулою кальмодуліну, іонами металів, іоном магнію. Локалізований у клітинній мембрані, цитоплазмі, ядрі, мембрані.

Література

  • Young P.W., Ehler E., Gautel M. (2001). Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly.. J. Cell Biol. 154: 123 — 136. PubMed DOI:10.1083/jcb.200102110
  • Fukuzawa A., Idowu S., Gautel M. (2005). Complete human gene structure of obscurin: implications for isoform generation by differential splicing.. J. Muscle Res. Cell Motil. 26: 427 — 434. PubMed DOI:10.1007/s10974-005-9025-6
  • Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. (2000). Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.. DNA Res. 7: 273 — 281. PubMed DOI:10.1093/dnares/7.4.271
  • Russell M.W., Raeker M.O., Korytkowski K.A., Sonneman K.J. (2002). Identification, tissue expression and chromosomal localization of human obscurin-MLCK, a member of the titin and Dbl families of myosin light chain kinases.. Gene 282: 237 — 246. PubMed DOI:10.1016/S0378-1119(01)00795-8
  • Bagnato P., Barone V., Giacomello E., Rossi D., Sorrentino V. (2003). Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles.. J. Cell Biol. 160: 245 — 253. PubMed DOI:10.1083/jcb.200208109

Примітки

  1. Human PubMed Reference:.
  2. Mouse PubMed Reference:.
  3. HUGO Gene Nomenclature Commitee, HGNC:15719 (англ.). Процитовано 28 серпня 2017.
  4. UniProt, Q5VST9 (англ.). Процитовано 28 серпня 2017.

Див. також

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