TLR4

TLR4 (англ. Toll like receptor 4) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 9-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 839 амінокислот, а молекулярна маса — 95 680[4].

TLR4
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 4G8A, 2Z62, 2Z63, 2Z65, 2Z66, 3FXI, 3UL7, 3UL8, 3UL9, 3ULA
Ідентифікатори
Символи	TLR4, ARMD10, CD284, TLR-4, TOLL, toll like receptor 4
Зовнішні ІД	OMIM: 603030 MGI: 96824 HomoloGene: 41317 GeneCards: TLR4
Онтологія гена Молекулярна функція • lipopolysaccharide immune receptor activity • lipopolysaccharide binding • GO:0001948 protein binding • transmembrane signaling receptor activity Клітинна компонента • цитоплазма • мембрана • perinuclear region of cytoplasm • cell surface • integral component of membrane • клітинна мембрана • endosome membrane • intrinsic component of plasma membrane • integral component of plasma membrane • lipopolysaccharide receptor complex • external side of plasma membrane Біологічний процес • positive regulation of MHC class II biosynthetic process • positive regulation of JNK cascade • TRIF-dependent toll-like receptor signaling pathway • cellular response to mechanical stimulus • positive regulation of interleukin-8 production • positive regulation of ERK1 and ERK2 cascade • T-helper 1 type immune response • positive regulation of platelet activation • positive regulation of interleukin-1 production • positive regulation of stress-activated MAPK cascade • positive regulation of NLRP3 inflammasome complex assembly • positive regulation of interleukin-12 production • positive regulation of interferon-alpha production • I-kappaB phosphorylation • positive regulation of nitric-oxide synthase biosynthetic process • positive regulation of B cell proliferation • defense response to bacterium • positive regulation of interleukin-6 production • activation of innate immune response • positive regulation of tumor necrosis factor production • negative regulation of tumor necrosis factor production • Вроджений імунітет • negative regulation of interleukin-17 production • I-kappaB kinase/NF-kappaB signaling • positive regulation of interferon-beta production • positive regulation of inflammatory response • toll-like receptor 4 signaling pathway • positive regulation of macrophage cytokine production • positive regulation of interleukin-10 production • immune system process • astrocyte development • intestinal epithelial structure maintenance • positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway • response to lipopolysaccharide • cellular response to lipoteichoic acid • positive regulation of NF-kappaB transcription factor activity • Імунна відповідь • negative regulation of interleukin-23 production • regulation of inflammatory response • positive regulation of chemokine production • lipopolysaccharide-mediated signaling pathway • detection of fungus • positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway • negative regulation of interferon-gamma production • response to bacterium • negative regulation of osteoclast differentiation • B cell proliferation involved in immune response • positive regulation of nitric oxide biosynthetic process • negative regulation of interleukin-6 production • positive regulation of interferon-gamma production • nitric oxide production involved in inflammatory response • MyD88-dependent toll-like receptor signaling pathway • regulation of dendritic cell cytokine production • positive regulation of gene expression • negative regulation of ERK1 and ERK2 cascade • positive regulation of I-kappaB kinase/NF-kappaB signaling • macrophage activation • detection of lipopolysaccharide • cellular response to lipopolysaccharide • positive regulation of lymphocyte proliferation • positive regulation of transcription by RNA polymerase II • MyD88-independent toll-like receptor signaling pathway • Сигнальна трансдукція • inflammatory response • GO:0051636 defense response to Gram-negative bacterium • toll-like receptor signaling pathway • GO:0060554, GO:0060555 Некроптоз • apoptotic signaling pathway • negative regulation of MyD88-independent toll-like receptor signaling pathway Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	7099	21898
Ensembl	ENSG00000136869	ENSMUSG00000039005
UniProt	O00206	Q9QUK6
RefSeq (мРНК)	NM_138557 NM_003266 NM_138554 NM_138556	NM_021297
RefSeq (білок)	NP_003257 NP_612564 NP_612567	NP_067272
Локус (UCSC)	Хр. 9: 117.7 – 117.72 Mb	н/д
PubMed search	[1]	[2]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Кодований геном білок за функцією належить до рецепторів. Задіяний у таких біологічних процесах, як імунітет, вроджений імунітет, запальна відповідь, альтернативний сплайсинг. Локалізований у клітинній мембрані, мембрані.

TLR4 здатний активувати NF-κB.