Тромбоспондин-1

Тромбоспондин-1 (англ. Thrombospondin 1) – білок, який кодується геном THBS1, розташованим у людей на короткому плечі 15-ї хромосоми. [3] Довжина поліпептидного ланцюга білка становить 1 170 амінокислот, а молекулярна маса — 129 383[4].

Тромбоспондин-1
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 1LSL, 1UX6, 1Z78, 1ZA4, 2ERF, 2ES3, 2OUH, 2OUJ, 3R6B, 5FOE
Ідентифікатори
Символи	THBS1, THBS, THBS-1, TSP, TSP-1, TSP1, thrombospondin 1
Зовнішні ІД	OMIM: 188060 MGI: 98737 HomoloGene: 31142 GeneCards: THBS1
Онтологія гена Молекулярна функція • calcium ion binding • heparin binding • extracellular matrix binding • fibroblast growth factor binding • phosphatidylserine binding • proteoglycan binding • collagen V binding • fibrinogen binding • low-density lipoprotein particle binding • integrin binding • laminin binding • fibronectin binding • identical protein binding • transforming growth factor beta binding • GO:0001948 protein binding • extracellular matrix structural constituent Клітинна компонента • endoplasmic reticulum lumen • platelet alpha granule • cell surface • Ендоплазматичний ретикулум • Екзосома • GO:0005578 Позаклітинна матриця • secretory granule • platelet alpha granule lumen • Фібриноген • sarcoplasmic reticulum • external side of plasma membrane • цитоплазма • extracellular space • extracellular region • collagen-containing extracellular matrix Біологічний процес • positive regulation of transforming growth factor beta receptor signaling pathway • cellular response to heat • negative regulation of fibrinolysis • protein O-linked fucosylation • response to progesterone • response to magnesium ion • positive regulation of translation • negative regulation of endothelial cell migration • negative regulation of cell-matrix adhesion • negative regulation of long-chain fatty acid import across plasma membrane • positive regulation of reactive oxygen species metabolic process • positive regulation of blood coagulation • positive regulation of blood vessel endothelial cell migration • positive regulation of macrophage chemotaxis • positive regulation of protein kinase B signaling • negative regulation of plasminogen activation • negative regulation of blood vessel endothelial cell migration • negative regulation of extrinsic apoptotic signaling pathway • response to endoplasmic reticulum stress • positive regulation of endothelial cell apoptotic process • response to unfolded protein • positive regulation of chemotaxis • negative regulation of cGMP-mediated signaling • positive regulation of phosphorylation • inflammatory response • negative regulation of focal adhesion assembly • chronic inflammatory response • negative regulation of nitric oxide mediated signal transduction • engulfment of apoptotic cell • extracellular matrix organization • positive regulation of macrophage activation • sprouting angiogenesis • negative regulation of apoptotic process • response to glucose • positive regulation of angiogenesis • response to calcium ion • positive regulation of transforming growth factor beta1 production • Адгезія клітин • behavioral response to pain • Імунна відповідь • negative regulation of interleukin-12 production • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to hypoxia • positive regulation of cell migration • platelet degranulation • negative regulation of endothelial cell chemotaxis • negative regulation of endothelial cell proliferation • positive regulation of endothelial cell migration • negative regulation of fibroblast growth factor receptor signaling pathway • peptide cross-linking • negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • negative regulation of dendritic cell antigen processing and presentation • negative regulation of angiogenesis • cell migration • positive regulation of fibroblast migration • response to testosterone • cellular response to tumor necrosis factor • cellular response to growth factor stimulus • positive regulation of transforming growth factor beta production • response to mechanical stimulus • positive regulation of cell population proliferation • positive regulation of smooth muscle cell proliferation • regulation of megakaryocyte differentiation • negative regulation of cell migration involved in sprouting angiogenesis • negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • negative regulation of sprouting angiogenesis Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	7057	21825
Ensembl	ENSG00000137801	ENSMUSG00000040152
UniProt	P07996	P35441
RefSeq (мРНК)	NM_003246	NM_011580 NM_001313914
RefSeq (білок)	NP_003237	н/д
Локус (UCSC)	Хр. 15: 39.58 – 39.6 Mb	Хр. 2: 118.11 – 118.13 Mb
PubMed search	[1]	[2]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Задіяний у таких біологічних процесах як клітинна адгезія, відповідь на порушення конформації білку. Білок має сайт для зв'язування з іоном кальцію, з молекулою гепарину. Локалізований у ендоплазматичному ретикулумі, саркоплазматичному ретикулумі.