BMP2

BMP2 (англ. Bone morphogenetic protein 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 20-ї хромосоми.[4] Довжина поліпептидного ланцюга білка становить 396 амінокислот, а молекулярна маса — 44 702[5].

BMP2
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 1ES7, 1REU, 1REW, 2GOO, 2H62, 2H64, 2QJ9, 2QJA, 2QJB, 3BK3, 3BMP, 4MID, 4N1D, 4UHY, 4UHZ, 4UI0, 4UI1, 4UI2
Ідентифікатори
Символи	BMP2, BDA2, BMP2A, bone morphogenetic protein 2, SSFSC, SSFSC1
Зовнішні ІД	OMIM: 112261 MGI: 88177 HomoloGene: 926 GeneCards: BMP2
Пов'язані генетичні захворювання
ожиріння, brachydactyly type A2[1]
Онтологія гена Молекулярна функція • signaling receptor binding • cytokine activity • co-receptor binding • phosphatase activator activity • growth factor activity • BMP receptor binding • GO:0001948 protein binding • NAD-retinol dehydrogenase activity • SMAD binding • protein heterodimerization activity • transforming growth factor beta receptor binding Клітинна компонента • extracellular region • cell surface • BMP receptor complex • extracellular space • внутрішньоклітинна мембранна органела Біологічний процес • skeletal system development • positive regulation of Wnt signaling pathway by BMP signaling pathway • positive regulation of protein phosphorylation • mesenchyme development • negative regulation of cell cycle • odontogenesis of dentin-containing tooth • telencephalon regionalization • protein phosphorylation • atrioventricular valve morphogenesis • proteoglycan metabolic process • mesenchymal cell differentiation • pericardium development • positive regulation of ERK1 and ERK2 cascade • BMP signaling pathway involved in heart induction • animal organ morphogenesis • inner ear development • cardiocyte differentiation • negative regulation of canonical Wnt signaling pathway • negative regulation of cell population proliferation • positive regulation of p38MAPK cascade • pathway-restricted SMAD protein phosphorylation • cell fate commitment • regulation of transcription, DNA-templated • SMAD protein signal transduction • ossification • in utero embryonic development • mesenchymal cell proliferation involved in ureteric bud development • regulation of odontogenesis of dentin-containing tooth • positive regulation of transcription, DNA-templated • positive regulation of Wnt signaling pathway • heart development • telencephalon development • branching involved in ureteric bud morphogenesis • negative regulation of Wnt signaling pathway involved in heart development • cartilage development • bone mineralization involved in bone maturation • positive regulation of cartilage development • positive regulation of neuron differentiation • positive regulation of cell differentiation • thyroid-stimulating hormone-secreting cell differentiation • inflammatory response • positive regulation of fat cell differentiation • negative regulation of steroid biosynthetic process • positive regulation of MAPK cascade • Notch signaling pathway • bone mineralization • Диференціація клітин • chondrocyte differentiation • corticotropin hormone secreting cell differentiation • positive regulation of astrocyte differentiation • positive regulation of bone mineralization • cellular response to organic cyclic compound • positive regulation of ossification • negative regulation of transcription by RNA polymerase II • positive regulation of epithelial to mesenchymal transition • positive regulation of phosphatase activity • negative regulation of calcium-independent cell-cell adhesion • positive regulation of osteoblast differentiation • protein destabilization • embryonic heart tube anterior/posterior pattern specification • osteoblast differentiation • Епітеліально-мезенхімальний перехід • positive regulation of protein binding • negative regulation of transcription, DNA-templated • positive regulation of odontogenesis • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus • negative regulation of aldosterone biosynthetic process • positive regulation of osteoblast proliferation • response to hypoxia • positive regulation of endothelial cell proliferation • positive regulation of cell migration • negative regulation of cortisol biosynthetic process • cell-cell signaling • positive regulation of pathway-restricted SMAD protein phosphorylation • cellular response to growth factor stimulus • cellular response to BMP stimulus • cardiac muscle tissue morphogenesis • endocardial cushion morphogenesis • multicellular organism development • negative regulation of cardiac muscle cell differentiation • positive regulation of apoptotic process • negative regulation of insulin-like growth factor receptor signaling pathway • positive regulation of transcription by RNA polymerase II • cardiac epithelial to mesenchymal transition • positive regulation of pri-miRNA transcription by RNA polymerase II • positive regulation of gene expression • BMP signaling pathway • cardiac muscle cell differentiation • cell development • regulation of signaling receptor activity • negative regulation of gene expression • response to bacterium • regulation of apoptotic process • regulation of MAPK cascade Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	650	12156
Ensembl	ENSG00000125845	ENSMUSG00000027358
UniProt	P12643	P21274
RefSeq (мРНК)	NM_001200	NM_007553
RefSeq (білок)	NP_001191	NP_031579
Локус (UCSC)	Хр. 20: 6.77 – 6.78 Mb	Хр. 2: 133.55 – 133.56 Mb
PubMed search	[2]	[3]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Кодований геном білок за функціями належить до цитокінів, факторів росту, білків розвитку. Задіяний у таких біологічних процесах, як остеогенез, диференціація клітин. Секретований назовні.