CCL5

CCL5 (англ. C-C motif chemokine ligand 5) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 91 амінокислот, а молекулярна маса — 9 990[4].

CCL5
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 1B3A, 1EQT, 1HRJ, 1RTN, 1RTO, 1U4L, 1U4M, 1U4P, 1U4R, 2L9H, 2VXW, 5CMD, 5DNF, 5COY
Ідентифікатори
Символи	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, C-C motif chemokine ligand 5
Зовнішні ІД	OMIM: 187011 MGI: 98262 HomoloGene: 2244 GeneCards: CCL5
Онтологія гена Молекулярна функція • CCR5 chemokine receptor binding • receptor signaling protein tyrosine kinase activator activity • chemokine activity • protein self-association • CCR4 chemokine receptor binding • phosphatidylinositol phospholipase C activity • protein kinase activity • cytokine activity • CCR1 chemokine receptor binding • phospholipase activator activity • chemokine receptor binding • protein homodimerization activity • chemokine receptor antagonist activity • GO:0001948 protein binding • chemoattractant activity • identical protein binding • CCR chemokine receptor binding Клітинна компонента • цитоплазма • extracellular region • extracellular space Біологічний процес • leukocyte cell-cell adhesion • positive regulation of cell-cell adhesion mediated by integrin • regulation of T cell activation • positive regulation of smooth muscle cell migration • activation of phospholipase D activity • negative regulation of viral genome replication • positive regulation of ERK1 and ERK2 cascade • positive regulation of innate immune response • cellular response to interferon-gamma • positive regulation of macrophage chemotaxis • calcium ion transport • Екзоцитоз • positive regulation of calcium ion transport • response to cytokine • regulation of insulin secretion • chemokine-mediated signaling pathway • positive regulation of cellular biosynthetic process • response to virus • positive regulation of monocyte chemotaxis • cellular response to fibroblast growth factor stimulus • neutrophil chemotaxis • response to tumor necrosis factor • negative regulation of T cell apoptotic process • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • negative regulation of macrophage apoptotic process • positive regulation of T cell proliferation • positive regulation of phosphorylation • inflammatory response • positive regulation of translational initiation • response to toxic substance • positive regulation of epithelial cell proliferation • positive regulation of tyrosine phosphorylation of STAT protein • cellular response to organic cyclic compound • cellular calcium ion homeostasis • protein tetramerization • хемотаксис • positive regulation of homotypic cell-cell adhesion • cellular response to interleukin-1 • Імунна відповідь • positive regulation of viral genome replication • positive regulation of receptor signaling pathway via JAK-STAT • lipopolysaccharide-mediated signaling pathway • positive regulation of T cell migration • regulation of chronic inflammatory response • positive regulation of smooth muscle cell proliferation • neutrophil activation • protein kinase B signaling • positive regulation of cell migration • positive regulation of natural killer cell chemotaxis • cell-cell signaling • eosinophil chemotaxis • dendritic cell chemotaxis • MAPK cascade • macrophage chemotaxis • positive regulation of T cell chemotaxis • regulation of neuron death • positive regulation of phosphatidylinositol 3-kinase signaling • negative regulation of G protein-coupled receptor signaling pathway • positive regulation of T cell apoptotic process • positive regulation of cell adhesion • negative regulation of chemokine-mediated signaling pathway • monocyte chemotaxis • positive chemotaxis • positive regulation of protein tyrosine kinase activity • cellular response to tumor necrosis factor • positive regulation of activation of Janus kinase activity • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • cytokine-mediated signaling pathway • lymphocyte chemotaxis Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	6352	20304
Ensembl	ENSG00000271503 ENSG00000274233	ENSMUSG00000035042
UniProt	P13501	P30882
RefSeq (мРНК)	NM_002985 NM_001278736	NM_013653
RefSeq (білок)	NP_001265665 NP_002976	NP_038681
Локус (UCSC)	Хр. 17: 35.87 – 35.88 Mb	Хр. 11: 83.42 – 83.42 Mb
PubMed search	[1]	[2]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Кодований геном білок за функцією належить до цитокінів. Задіяний у таких біологічних процесах, як запальна відповідь, хемотаксис. Секретований назовні.