MUC5AC
MUC5AC (англ. Mucin 5AC, oligomeric mucus/gel-forming) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 5 654 амінокислот, а молекулярна маса — 585 570[4].
Послідовність амінокислот
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSVGRRKLAL | LWALALALAC | TRHTGHAQDG | SSESSYKHHP | ALSPIARGPS | ||||
| GVPLRGATVF | PSLRTIPVVR | ASNPAHNGRV | CSTWGSFHYK | TFDGDVFRFP | ||||
| GLCNYVFSEH | CGAAYEDFNI | QLRRSQESAA | PTLSRVLMKV | DGVVIQLTKG | ||||
| SVLVNGHPVL | LPFSQSGVLI | QQSSSYTKVE | ARLGLVLMWN | HDDSLLLELD | ||||
| TKYANKTCGL | CGDFNGMPVV | SELLSHNTKL | TPMEFGNLQK | MDDPTDQCQD | ||||
| PVPEPPRNCS | TGFGICEELL | HGQLFSGCVA | LVDVGSYLEA | CRQDLCFCED | ||||
| TDLLSCVCHT | LAEYSRQCTH | AGGLPQDWRG | PDFCPQKCPN | NMQYHECRSP | ||||
| CADTCSNQEH | SRACEDHCVA | GCFCPEGTVL | DDIGQTGCVP | VSKCACVYNG | ||||
| AAYAPGATYS | TDCTNCTCSG | GRWSCQEVPC | PGTCSVLGGA | HFSTFDGKQY | ||||
| TVHGDCSYVL | TKPCDSSAFT | VLAELRRCGL | TDSETCLKSV | TLSLDGAQTV | ||||
| VVIKASGEVF | LNQIYTQLPI | SAANVTIFRP | STFFIIAQTS | LGLQLNLQLV | ||||
| PTMQLFMQLA | PKLRGQTCGL | CGNFNSIQAD | DFRTLSGVVE | ATAAAFFNTF | ||||
| KTQAACPNIR | NSFEDPCSLS | VENEKYAQHW | CSQLTDADGP | FGRCHAAVKP | ||||
| GTYYSNCMFD | TCNCERSEDC | LCAALSSYVH | ACAAKGVQLG | GWRDGVCTKP | ||||
| MTTCPKSMTY | HYHVSTCQPT | CRSLSEGDIT | CSVGFIPVDG | CICPKGTFLD | ||||
| DTGKCVQASN | CPCYHRGSMI | PNGESVHDSG | AICTCTHGKL | SCIGGQAPAP | ||||
| VCAAPMVFFD | CRNATPGDTG | AGCQKSCHTL | DMTCYSPQCV | PGCVCPDGLV | ||||
| ADGEGGCITA | EDCPCVHNEA | SYRAGQTIRV | GCNTCTCDSR | MWRCTDDPCL | ||||
| ATCAVYGDGH | YLTFDGQSYS | FNGDCEYTLV | QNHCGGKDST | QDSFRVVTEN | ||||
| VPCGTTGTTC | SKAIKIFLGG | FELKLSHGKV | EVIGTDESQE | VPYTIRQMGI | ||||
| YLVVDTDIGL | VLLWDKKTSI | FINLSPEFKG | RVCGLCGNFD | DIAVNDFATR | ||||
| SRSVVGDVLE | FGNSWKLSPS | CPDALAPKDP | CTANPFRKSW | AQKQCSILHG | ||||
| PTFAACHAHV | EPARYYEACV | NDACACDSGG | DCECFCTAVA | AYAQACHEVG | ||||
| LCVSWRTPSI | CPLFCDYYNP | EGQCEWHYQP | CGVPCLRTCR | NPRGDCLRDV | ||||
| RGLEGCYPKC | PPEAPIFDED | KMQCVATCPT | PPLPPRCHVH | GKSYRPGAVV | ||||
| PSDKNCQSCL | CTERGVECTY | KAEACVCTYN | GQRFHPGDVI | YHTTDGTGGC | ||||
| ISARCGANGT | IERRVYPCSP | TTPVPPTTFS | FSTPPLVVSS | THTPSNGPSS | ||||
| AHTGPPSSAW | PTTAGTSPRT | RLPTASASLP | PVCGEKCLWS | PWMDVSRPGR | ||||
| GTDSGDFDTL | ENLRAHGYRV | CESPRSVECR | AEDAPGVPLR | ALGQRVQCSP | ||||
| DVGLTCRNRE | QASGLCYNYQ | IRVQCCTPLP | CSTSSSPAQT | TPPTTSKTTE | ||||
| TRASGSSAPS | STPGTVSLST | ARTTPAPGTA | TSVKKTFSTP | SPPPVPATST | ||||
| SSMSTTAPGT | SVVSSKPTPT | EPSTSSCLQE | LCTWTEWIDG | SYPAPGINGG | ||||
| DFDTFQNLRD | EGYTFCESPR | SVQCRAESFP | NTPLADLGQD | VICSHTEGLI | ||||
| CLNKNQLPPI | CYNYEIRIQC | CETVNVCRDI | TRLPKTVATT | RPTPHPTGAQ | ||||
| TQTTFTTHMP | SASTEQPTAT | SRGGPTATSV | TQGTHTTLVT | RNCHPRCTWT | ||||
| KWFDVDFPSP | GPHGGDKETY | NNIIRSGEKI | CRRPEEITRL | QCRAKSHPEV | ||||
| SIEHLGQVVQ | CSREEGLVCR | NQDQQGPFKM | CLNYEVRVLC | CETPRGCHMT | ||||
| STPGSTSSSP | AQTTPSTTSK | TTETQASGSS | APSSTPGTVS | LSTARTTPAP | ||||
| GTATSVKKTF | STPSPPPVPA | TSTSSMSTTA | PGTSVVSSKP | TPTEPSTSSC | ||||
| LQELCTWTEW | IDGSYPAPGI | NGGDFDTFQN | LRDEGYTFCE | SPRSVQCRAE | ||||
| SFPNTPLADL | GQDVICSHTE | GLICLNKNQL | PPICYNYEIR | IQCCETVNVC | ||||
| RDITRPPKTV | ATTRPTPHPT | GAQTQTTFTT | HMPSASTEQP | TATSRGGPTA | ||||
| TSVTQGTHTT | PVTRNCHPRC | TWTTWFDVDF | PSPGPHGGDK | ETYNNIIRSG | ||||
| EKICRRPEEI | TRLQCRAKSH | PEVSIEHLGQ | VVQCSREEGL | VCRNQDQQGP | ||||
| FKMCLNYEVR | VLCCETPKGC | PVTSTPVTAP | STPSGRATSP | TQSTSSWQKS | ||||
| RTTTLVTTST | TSTPQTSTTY | AHTTSTTSAP | TARTTSAPTT | RTTSASPAST | ||||
| TSGPGNTPSP | VPTTSTISAP | TTSITSAPTT | STTSAPTSST | TSGPGTTPSP | ||||
| VPTTSITSAP | TTSTTSAPTT | STTSARTSST | TSATTTSRIS | GPETTPSPVP | ||||
| TTSTTSATTT | STTSAPTTST | TSAPTSSTTS | SPQTSTTSAP | TTSTTSGPGT | ||||
| TPSPVPTTST | TSAPTTRTTS | APKSSTTSAA | TTSTTSGPET | TPRPVPTTST | ||||
| TSSPTTSTTS | APTTSTTSAS | TTSTTSGAGT | TPSPVPTTST | TSAPTTSTTS | ||||
| APISSTTSAT | TTSTTSGPGT | TPSPVPTTST | TSAPTTSTTS | GPGTTPSAVP | ||||
| TTSITSAPTT | STNSAPISST | TSATTTSRIS | GPETTPSPVP | TASTTSASTT | ||||
| STTSGPGTTP | SPVPTTSTIS | VPTTSTTSAS | TTSTTSASTT | STTSGPGTTP | ||||
| SPVPTTSTTS | APTTSTTSAP | TTSTISAPTT | STTSATTTST | TSAPTPRRTS | ||||
| APTTSTISAS | TTSTTSATTT | STTSATTTST | ISAPTTSTTL | SPTTSTTSTT | ||||
| ITSTTSAPIS | STTSTPQTST | TSAPTTSTTS | GPGTTSSPVP | TTSTTSAPTT | ||||
| STTSAPTTRT | TSVPTSSTTS | TATTSTTSGP | GTTPSPVPTT | STTSAPTTRT | ||||
| TSAPTTSTTS | APTTSTTSAP | TSSTTSATTT | STISVPTTST | TSVPGTTPSP | ||||
| VPTTSTISVP | TTSTTSASTT | STTSGPGTTP | SPVPTTSTTS | APTTSTTSAP | ||||
| TTSTISAPTT | STPSAPTTST | TLAPTTSTTS | APTTSTTSTP | TSSTTSSPQT | ||||
| STTSASTTSI | TSGPGTTPSP | VPTTSTTSAP | TTSTTSAATT | STISAPTTST | ||||
| TSAPTTSTTS | ASTASKTSGL | GTTPSPIPTT | STTSPPTTST | TSASTASKTS | ||||
| GPGTTPSPVP | TTSTIFAPRT | STTSASTTST | TPGPGTTPSP | VPTTSTASVS | ||||
| KTSTSHVSIS | KTTHSQPVTR | DCHLRCTWTK | WFDIDFPSPG | PHGGDKETYN | ||||
| NIIRSGEKIC | RRPEEITRLQ | CRAESHPEVS | IEHLGQVVQC | SREEGLVCRN | ||||
| QDQQGPFKMC | LNYEVRVLCC | ETPKGCPVTS | TPVTAPSTPS | GRATSPTQST | ||||
| SSWQKSRTTT | LVTTSTTSTP | QTSTTSAPTT | STTSAPTTST | TSAPTTSTTS | ||||
| TPQTSISSAP | TSSTTSAPTS | STISARTTSI | ISAPTTSTTS | SPTTSTTSAT | ||||
| TTSTTSAPTS | STTSTPQTSK | TSAATSSTTS | GSGTTPSPVT | TTSTASVSKT | ||||
| STSHVSVSKT | THSQPVTRDC | HPRCTWTKWF | DVDFPSPGPH | GGDKETYNNI | ||||
| IRSGEKICRR | PEEITRLQCR | AKSHPEVSIE | HLGQVVQCSR | EEGLVCRNQD | ||||
| QQGPFKMCLN | YEVRVLCCET | PKGCPVTSTS | VTAPSTPSGR | ATSPTQSTSS | ||||
| WQKSRTTTLV | TSSITSTTQT | STTSAPTTST | TPASIPSTTS | APTTSTTSAP | ||||
| TTSTTSAPTT | STTSTPQTTT | SSAPTSSTTS | APTTSTISAP | TTSTISAPTT | ||||
| STTSAPTAST | TSAPTSTSSA | PTTNTTSAPT | TSTTSAPITS | TISAPTTSTT | ||||
| STPQTSTISS | PTTSTTSTPQ | TSTTSSPTTS | TTSAPTTSTT | SAPTTSTTST | ||||
| PQTSISSAPT | SSTTSAPTAS | TISAPTTSTT | SFHTTSTTSP | PTSSTSSTPQ | ||||
| TSKTSAATSS | TTSGSGTTPS | PVPTTSTASV | SKTSTSHVSV | SKTTHSQPVT | ||||
| RDCHPRCTWT | KWFDVDFPSP | GPHGGDKETY | NNIIRSGEKI | CRRPEEITRL | ||||
| QCRAESHPEV | SIEHLGQVVQ | CSREEGLVCR | NQDQQGPFKM | CLNYEVRVLC | ||||
| CETPKGCPVT | STPVTAPSTP | SGRATSPTQS | TSSWQKSRTT | TLVTTSTTST | ||||
| PQTSTTSAPT | TSTIPASTPS | TTSAPTTSTT | SAPTTSTTSA | PTHRTTSGPT | ||||
| TSTTLAPTTS | TTSAPTTSTN | SAPTTSTISA | STTSTISAPT | TSTISSPTSS | ||||
| TTSTPQTSKT | SAATSSTTSG | SGTTPSPVPT | TSTTSASTTS | TTSAPTTSTT | ||||
| SGPGTTPSPV | PSTSTTSAAT | TSTTSAPTTR | TTSAPTSSMT | SGPGTTPSPV | ||||
| PTTSTTSAPT | TSTTSGPGTT | PSPVPTTSTT | SAPITSTTSG | PGSTPSPVPT | ||||
| TSTTSAPTTS | TTSASTASTT | SGPGTTPSPV | PTTSTTSAPT | TRTTSASTAS | ||||
| TTSGPGSTPS | PVPTTSTTSA | PTTRTTPAST | ASTTSGPGTT | PSPVPTTSTT | ||||
| SASTTSTISL | PTTSTTSAPI | TSMTSGPGTT | PSPVPTTSTT | SAPTTSTTSA | ||||
| STASTTSGPG | TTPSPVPTTS | TTSAPTTSTT | SASTASTTSG | PGTSLSPVPT | ||||
| TSTTSAPTTS | TTSGPGTTPS | PVPTTSTTSA | PTTSTTSGPG | TTPSPVPTTS | ||||
| TTPVSKTSTS | HLSVSKTTHS | QPVTSDCHPL | CAWTKWFDVD | FPSPGPHGGD | ||||
| KETYNNIIRS | GEKICRRPEE | ITRLQCRAES | HPEVNIEHLG | QVVQCSREEG | ||||
| LVCRNQDQQG | PFKMCLNYEV | RVLCCETPRG | CPVTSVTPYG | TSPTNALYPS | ||||
| LSTSMVSASV | ASTSVASSSV | ASSSVAYSTQ | TCFCNVADRL | YPAGSTIYRH | ||||
| RDLAGHCYYA | LCSQDCQVVR | GVDSDCPSTT | LPPAPATSPS | ISTSEPVTEL | ||||
| GCPNAVPPRK | KGETWATPNC | SEATCEGNNV | ISLRPRTCPR | VEKPTCANGY | ||||
| PAVKVADQDG | CCHHYQCQCV | CSGWGDPHYI | TFDGTYYTFL | DNCTYVLVQQ | ||||
| IVPVYGHFRV | LVDNYFCGAE | DGLSCPRSII | LEYHQDRVVL | TRKPVHGVMT | ||||
| NEIIFNNKVV | SPGFRKNGIV | VSRIGVKMYA | TIPELGVQVM | FSGLIFSVEV | ||||
| PFSKFANNTE | GQCGTCTNDR | KDECRTPRGT | VVASCSEMSG | LWNVSIPDQP | ||||
| ACHRPHPTPT | TVGPTTVGST | TVGPTTVGST | TVGPTTPPAP | CLPSPICQLI | ||||
| LSKVFEPCHT | VIPPLLFYEG | CVFDRCHMTD | LDVVCSSLEL | YAALCASHDI | ||||
| CIDWRGRTGH | MCPFTCPADK | VYQPCGPSNP | SYCYGNDSAS | LGALPEAGPI | ||||
| TEGCFCPEGM | TLFSTSAQVC | VPTGCPRCLG | PHGEPVKVGH | TVGMDCQECT | ||||
| CEAATWTLTC | RPKLCPLPPA | CPLPGFVPVP | AAPQAGQCCP | QYSCACNTSR | ||||
| CPAPVGCPEG | ARAIPTYQEG | ACCPVQNCSW | TVCSINGTLY | QPGAVVSSSL | ||||
| CETCRCELPG | GPPSDAFVVS | CETQICNTHC | PVGFEYQEQS | GQCCGTCVQV | ||||
| ACVTNTSKSP | AHLFYPGETW | SDAGNHCVTH | QCEKHQDGLV | VVTTKKACPP | ||||
| LSCSLDEARM | SKDGCCRFCP | PPPPPYQNQS | TCAVYHRSLI | IQQQGCSSSE | ||||
| PVRLAYCRGN | CGDSSSMYSL | EGNTVEHRCQ | CCQELRTSLR | NVTLHCTDGS | ||||
| SRAFSYTEVE | ECGCMGRRCP | APGDTQHSEE | AEPEPSQEAE | SGSWERGVPV | ||||
| SPMH |
| MUC5AC | |||||||||||||||||
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| Ідентифікатори | |||||||||||||||||
| Символи | MUC5AC, MUC5, TBM, leB, mucin, mucin 5AC, oligomeric mucus/gel-forming | ||||||||||||||||
| Зовнішні ІД | OMIM: 158373 MGI: 104697 HomoloGene: 137237 GeneCards: MUC5AC | ||||||||||||||||
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| Види | Людина | Миша | |||||||||||||||
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| RefSeq (мРНК) |
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| RefSeq (білок) |
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| Локус (UCSC) | Хр. 11: 1.16 – 1.2 Mb | Хр. 7: 141.79 – 141.82 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
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Секретований назовні.
Література
- Escande F., Aubert J.-P., Porchet N., Buisine M.P. (2001). Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region.. Biochem. J. 358: 763 — 772. PubMed DOI:10.1042/0264-6021:3580763
- Li D., Gallup M., Fan N., Szymkowski D.E., Basbaum C.B. (1998). Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts.. J. Biol. Chem. 273: 6812 — 6820. PubMed DOI:10.1074/jbc.273.12.6812
- Klomp L.W., Van Rens L., Strous G.J. (1995). Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains.. Biochem. J. 308: 831 — 838. PubMed DOI:10.1042/bj3080831
- Lidell M.E., Hansson G.C. (2006). Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC mucin.. Biochem. J. 399: 121 — 129. PubMed DOI:10.1042/BJ20060443
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14: 2121 — 2127. 2004. PubMed DOI:10.1101/gr.2596504
- Perez-Vilar J., Randell S.H., Boucher R.C. (2004). C-Mannosylation of MUC5AC and MUC5B Cys subdomains.. Glycobiology 14: 325 — 337. PubMed DOI:10.1093/glycob/cwh041
Примітки
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:7515 (англ.). Процитовано 8 вересня 2017.
- UniProt, P98088 (англ.). Процитовано 8 вересня 2017.
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