UBB

UBB
Наявні структури
PDB	Пошук для людей: PDBe RCSB
Список кодів PDB
	2KHW, 2MBB, 2MRO, 2MSG, 4UEL, 4UF6, 4WLR, 4WUR, 4ZPZ, 5CAW, 3OJ3, 5DK8, 5CRA, 4ZFR, 5CVO, 3ZLZ, 4WHV, 4ZFT, 3ZNH, 5D0M, 2Y5B, 2KWV, 5D0K, 5DFL, 5CVM, 4WZP, 5EDV, 5CVN, 2KWU, 4XOF, 5BNB, 2N13, 4ZUX, 5IFR, 5IBK, 5KGF, 5JG6, 5K9P, 5E6J
Ідентифікатори
Символи	UBB, HEL-S-50, Ubiquitin B
Зовнішні ІД	OMIM: 191339 HomoloGene: 75104 GeneCards: UBB
Онтологія гена
Молекулярна функція	• GO:0001948 protein binding; • protein tag; • ubiquitin protein ligase binding;
Клітинна компонента	• цитоплазма; • endocytic vesicle membrane; • гіалоплазма; • мітохондрія; • neuron projection; • клітинне ядро; • Екзосома; • клітинна мембрана; • Нуклеоплазма; • neuronal cell body; • endosome membrane; • extracellular space; • мітохондріальна зовнішня мембрана; • endoplasmic reticulum quality control compartment; • везикула; • endoplasmic reticulum membrane; • host cell;
Біологічний процес	• DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • negative regulation of epidermal growth factor receptor signaling pathway; • interstrand cross-link repair; • nucleotide-excision repair, DNA damage recognition; • positive regulation of canonical Wnt signaling pathway; • tumor necrosis factor-mediated signaling pathway; • regulation of type I interferon production; • positive regulation of protein monoubiquitination; • TRIF-dependent toll-like receptor signaling pathway; • Fc-epsilon receptor signaling pathway; • endosomal transport; • global genome nucleotide-excision repair; • NIK/NF-kappaB signaling; • G2/M transition of mitotic cell cycle; • stress-activated MAPK cascade; • transforming growth factor beta receptor signaling pathway; • macroautophagy; • negative regulation of canonical Wnt signaling pathway; • nucleotide-excision repair, DNA gap filling; • error-free translesion synthesis; • regulation of tumor necrosis factor-mediated signaling pathway; • stimulatory C-type lectin receptor signaling pathway; • negative regulation of transforming growth factor beta receptor signaling pathway; • JNK cascade; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • nucleotide-excision repair, DNA incision; • I-kappaB kinase/NF-kappaB signaling; • Вроджений імунітет; • Notch signaling pathway; • neuron projection morphogenesis; • regulation of mRNA stability; • protein polyubiquitination; • negative regulation of apoptotic process; • negative regulation of transcription by RNA polymerase II; • virion assembly; • positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; • positive regulation of NF-kappaB transcription factor activity; • anaphase-promoting complex-dependent catabolic process; • negative regulation of type I interferon production; • nucleotide-binding oligomerization domain containing signaling pathway; • positive regulation of protein ubiquitination; • GO:0046795 intracellular transport of virus; • regulation of proteasomal protein catabolic process; • GO:0019067 viral life cycle; • MyD88-dependent toll-like receptor signaling pathway; • error-prone translesion synthesis; • MAPK cascade; • regulation of mitochondrial membrane potential; • fibroblast growth factor receptor signaling pathway; • ion transmembrane transport; • glycogen biosynthetic process; • regulation of neuron death; • positive regulation of apoptotic process; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • translesion synthesis; • transcription-coupled nucleotide-excision repair; • mitochondrion transport along microtubule; • T cell receptor signaling pathway; • MyD88-independent toll-like receptor signaling pathway; • positive regulation of transcription by RNA polymerase II; • regulation of signal transduction by p53 class mediator; • positive regulation of epidermal growth factor receptor signaling pathway; • Wnt signaling pathway; • nucleotide-excision repair, DNA duplex unwinding; • nucleotide-excision repair, DNA incision, 5'-to lesion; • ERBB2 signaling pathway; • Wnt signaling pathway, planar cell polarity pathway; • nucleotide-excision repair, preincision complex assembly; • proteasome-mediated ubiquitin-dependent protein catabolic process; • cellular protein metabolic process; • Згортання білків; • negative regulation of G2/M transition of mitotic cell cycle; • Убіквітин-залежний протеоліз; • protein deubiquitination; • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; • entry of bacterium into host cell; • transmembrane transport; • regulation of necroptotic process; • membrane organization; • endoplasmic reticulum mannose trimming; • cellular iron ion homeostasis; • regulation of hematopoietic stem cell differentiation; • protein targeting to peroxisome; • male meiosis I; • female meiosis I; • male gonad development; • female gonad development; • cytokine-mediated signaling pathway; • modification-dependent protein catabolic process; • hypothalamus gonadotrophin-releasing hormone neuron development; • adipose tissue development; • fat pad development; • interleukin-1-mediated signaling pathway; • seminiferous tubule development; • energy homeostasis;
	Джерела:Amigo / QuickGO
Шаблон експресії
	Більше даних
Ортологи
	7314
	н/д
	ENSG00000170315
	н/д
	P0CG47
	н/д
NM_018955; NM_001281716; NM_001281717; NM_001281718; NM_001281719;
	NM_001281720
	н/д
NP_001268645; NP_001268646; NP_001268647; NP_001268648; NP_001268649;
	NP_061828
	н/д
	Вікідані
Див./Ред. для людей

UBB (англ. Ubiquitin B) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17-ї хромосоми.[2] Довжина поліпептидного ланцюга білка становить 229 амінокислот, а молекулярна маса — 25 762[3].

Послідовність амінокислот

10	20	30	40	50
MQIFVKTLTG	KTITLEVEPS	DTIENVKAKI	QDKEGIPPDQ	QRLIFAGKQL
EDGRTLSDYN	IQKESTLHLV	LRLRGGMQIF	VKTLTGKTIT	LEVEPSDTIE
NVKAKIQDKE	GIPPDQQRLI	FAGKQLEDGR	TLSDYNIQKE	STLHLVLRLR
GGMQIFVKTL	TGKTITLEVE	PSDTIENVKA	KIQDKEGIPP	DQQRLIFAGK
QLEDGRTLSD	YNIQKESTLH	LVLRLRGGC

A: Аланін

C: Цистеїн

D: Аспарагінова кислота

E: Глутамінова кислота

F: Фенілаланін

G: Гліцин

H: Гістидин

I: Ізолейцин

K: Лізин

L: Лейцин

M: Метіонін

N: Аспарагін

P: Пролін

Q: Глутамін

R: Аргінін

S: Серин

T: Треонін

V: Валін

Y: Тирозин

Кодований геном білок за функцією належить до фосфопротеїнів. Локалізований у цитоплазмі, ядрі.

Література

Baker R.T., Board P.G. (1987). The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily.. Nucleic Acids Res. 15: 443 — 463. PubMed DOI:10.1093/nar/15.2.443
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14: 2121 — 2127. 2004. PubMed DOI:10.1101/gr.2596504
Schlesinger D.H., Goldstein G. (1975). Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man.. Nature 255: 423 — 424. PubMed DOI:10.1038/255423a0
Huang F., Kirkpatrick D., Jiang X., Gygi S.P., Sorkin A. (2006). Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.. Mol. Cell 21: 737 — 748. PubMed DOI:10.1016/j.molcel.2006.02.018
Okumura F., Hatakeyama S., Matsumoto M., Kamura T., Nakayama K. (2004). Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis.. J. Biol. Chem. 279: 53533 — 53543. PubMed DOI:10.1074/jbc.M402916200
Komander D. (2009). The emerging complexity of protein ubiquitination.. Biochem. Soc. Trans. 37: 937 — 953. PubMed DOI:10.1042/BST0370937

Примітки

Human PubMed Reference:.
HUGO Gene Nomenclature Commitee, HGNC:12463 (англ.). Процитовано 12 вересня 2017.
UniProt, P0CG47 (англ.). Процитовано 12 вересня 2017.

Див. також

Хромосома 17

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] Human PubMed Reference:.

[HGNC-2] HUGO Gene Nomenclature Commitee, HGNC:12463 (англ.). Процитовано 12 вересня 2017.

[UniProt-3] UniProt, P0CG47 (англ.). Процитовано 12 вересня 2017.