VEGFA

VEGFA (англ. Vascular endothelial growth factor A) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 232 амінокислот, а молекулярна маса — 27 042[4].

VEGFA
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 1BJ1, 1CZ8, 1FLT, 1KAT, 1KMX, 1MJV, 1MKG, 1MKK, 1QTY, 1TZH, 1TZI, 1VGH, 1VPF, 1VPP, 2FJG, 2FJH, 2QR0, 2VGH, 2VPF, 3BDY, 3P9W, 3QTK, 3S1B, 3S1K, 3V2A, 4DEQ, 4GLN, 4GLS, 4KZN, 4QAF, 4WPB, 4ZFF, 5HHC, 5FV1, 5FV2, 5HHD, 5DN2
Ідентифікатори
Символи	VEGFA, MVCD1, VEGF, VPF, vascular endothelial growth factor A
Зовнішні ІД	OMIM: 192240 MGI: 103178 HomoloGene: 2534 GeneCards: VEGFA
Онтологія гена Молекулярна функція • heparin binding • extracellular matrix binding • cytokine activity • growth factor activity • neuropilin binding • vascular endothelial growth factor receptor 2 binding • receptor ligand activity • vascular endothelial growth factor receptor 1 binding • protein homodimerization activity • platelet-derived growth factor receptor binding • GO:0001948 protein binding • vascular endothelial growth factor receptor binding • fibronectin binding • chemoattractant activity • identical protein binding • protein heterodimerization activity Клітинна компонента • цитоплазма • мембрана • extracellular region • cell surface • secretory granule • platelet alpha granule lumen • extracellular space • GO:0005578 Позаклітинна матриця Біологічний процес • cardiac vascular smooth muscle cell development • positive regulation of protein phosphorylation • positive regulation of MAP kinase activity • vascular endothelial growth factor signaling pathway • positive regulation of receptor internalization • outflow tract morphogenesis • mammary gland alveolus development • monocyte differentiation • cell migration involved in sprouting angiogenesis • васкулогенез • positive regulation of retinal ganglion cell axon guidance • vascular endothelial growth factor receptor signaling pathway • positive regulation of vascular permeability • positive regulation of mesenchymal cell proliferation • Ангіогенез • positive regulation of blood vessel endothelial cell migration • positive regulation of ERK1 and ERK2 cascade • mesoderm development • positive regulation of positive chemotaxis • positive regulation of p38MAPK cascade • positive regulation of neuroblast proliferation • dopaminergic neuron differentiation • positive regulation of branching involved in ureteric bud morphogenesis • kidney development • lung development • coronary artery morphogenesis • in utero embryonic development • cell maturation • commissural neuron axon guidance • positive regulation of peptidyl-serine phosphorylation • positive regulation of CREB transcription factor activity • basophil chemotaxis • artery morphogenesis • regulation of transcription from RNA polymerase II promoter in response to hypoxia • positive regulation of peptidyl-tyrosine autophosphorylation • positive regulation of peptidyl-tyrosine phosphorylation • branching involved in blood vessel morphogenesis • positive regulation of protein localization to early endosome • primitive erythrocyte differentiation • positive regulation of protein kinase D signaling • Лактація • Диференціація клітин • epithelial cell differentiation • positive regulation of leukocyte migration • positive regulation of epithelial cell proliferation • negative regulation of apoptotic process • negative regulation of transcription by RNA polymerase II • нейробіологія розвитку • macrophage differentiation • positive regulation of angiogenesis • regulation of retinal ganglion cell axon guidance • lymph vessel morphogenesis • post-embryonic camera-type eye development • regulation of cell shape • ovarian follicle development • positive regulation of cellular component movement • branching morphogenesis of an epithelial tube • coronary vein morphogenesis • surfactant homeostasis • positive regulation of vascular endothelial growth factor receptor signaling pathway • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to hypoxia • positive regulation of endothelial cell proliferation • positive regulation of protein-containing complex assembly • positive regulation of protein kinase C signaling • positive regulation of cell migration • heart morphogenesis • platelet degranulation • positive regulation of axon extension involved in axon guidance • positive regulation of endothelial cell migration • multicellular organism development • positive regulation of histone deacetylase activity • tube formation • positive regulation of gene expression • positive regulation of protein autophosphorylation • endothelial cell chemotaxis • positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway • eye photoreceptor cell development • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • positive regulation of focal adhesion assembly • cellular response to vascular endothelial growth factor stimulus • activation of protein kinase activity • positive regulation of cell division • camera-type eye morphogenesis • positive regulation of transcription by RNA polymerase II • positive regulation of cell adhesion • cellular response to hypoxia • positive chemotaxis • regulation of transcription by RNA polymerase II • positive regulation of cell population proliferation • induction of positive chemotaxis • positive regulation of mast cell chemotaxis • motor neuron migration • positive regulation of tyrosine phosphorylation of STAT protein • growth • VEGF-activated neuropilin signaling pathway • positive regulation of phosphorylation • regulation of signaling receptor activity • negative regulation of gene expression • cytokine-mediated signaling pathway • positive regulation of cell migration involved in sprouting angiogenesis • cellular stress response to acid chemical • positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • positive regulation of sprouting angiogenesis • positive regulation of DNA biosynthetic process • sprouting angiogenesis • regulation of nitric oxide mediated signal transduction • positive regulation of cold-induced thermogenesis • Сигнальна трансдукція Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	7422	22339
Ensembl	ENSG00000112715	ENSMUSG00000023951
UniProt	P15692	Q00731
RefSeq (мРНК)	NM_003376 NM_001025366 NM_001025367 NM_001025368 NM_001025369 NM_001025370 NM_001033756 NM_001171622 NM_001171623 NM_001171624 NM_001171625 NM_001171626 NM_001171627 NM_001171628 NM_001171629 NM_001171630 NM_001204384 NM_001204385 NM_001287044 NM_001317010	NM_001025250 NM_001025257 NM_001110266 NM_001110267 NM_001110268 NM_001287056 NM_001287057 NM_001287058 NM_009505 NM_001317041
RefSeq (білок)	NP_001020537 NP_001020538 NP_001020539 NP_001020540 NP_001020541 NP_001028928 NP_001165093 NP_001165094 NP_001165095 NP_001165096 NP_001165097 NP_001165098 NP_001165099 NP_001165100 NP_001165101 NP_001191313 NP_001191314 NP_001273973 NP_001303939 NP_003367	NP_001020421 NP_001020428 NP_001103736 NP_001103737 NP_001103738 NP_001273985 NP_001273986 NP_001273987 NP_001303970 NP_033531
Локус (UCSC)	Хр. 6: 43.77 – 43.79 Mb	Хр. 17: 46.02 – 46.03 Mb
PubMed search	[1]	[2]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Кодований геном білок за функціями належить до факторів росту, мітогенів, білків розвитку. Задіяний у таких біологічних процесах, як ангіогенез, диференціація клітин, альтернативний сплайсинг. Білок має сайт для зв'язування з з молекулою гепарину. Секретований назовні.