ASPM
ASPM (англ. Abnormal spindle microtubule assembly) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. [3] Довжина поліпептидного ланцюга білка становить 3 477 амінокислот, а молекулярна маса — 409 800[4].
Послідовність амінокислот
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MANRRVGRGC | WEVSPTERRP | PAGLRGPAAE | EEASSPPVLS | LSHFCRSPFL | ||||
| CFGDVLLGAS | RTLSLALDNP | NEEVAEVKIS | HFPAADLGFS | VSQRCFVLQP | ||||
| KEKIVISVNW | TPLKEGRVRE | IMTFLVNDVL | KHQAILLGNA | EEQKKKKRSL | ||||
| WDTIKKKKIS | ASTSHNRRVS | NIQNVNKTFS | VSQKVDRVRS | PLQACENLAM | ||||
| NEGGPPTENN | SLILEENKIP | ISPISPAFNE | CHGATCLPLS | VRRSTTYSSL | ||||
| HASENRELLN | VHSANVSKVS | FNEKAVTETS | FNSVNVNGQR | GENSKLSLTP | ||||
| NCSSTLNITQ | SQIHFLSPDS | FVNNSHGANN | ELELVTCLSS | DMFMKDNSQP | ||||
| VHLESTIAHE | IYQKILSPDS | FIKDNYGLNQ | DLESESVNPI | LSPNQFLKDN | ||||
| MAYMCTSQQT | CKVPLSNENS | QVPQSPEDWR | KSEVSPRIPE | CQGSKSPKAI | ||||
| FEELVEMKSN | YYSFIKQNNP | KFSAVQDISS | HSHNKQPKRR | PILSATVTKR | ||||
| KATCTRENQT | EINKPKAKRC | LNSAVGEHEK | VINNQKEKED | FHSYLPIIDP | ||||
| ILSKSKSYKN | EVTPSSTTAS | VARKRKSDGS | MEDANVRVAI | TEHTEVREIK | ||||
| RIHFSPSEPK | TSAVKKTKNV | TTPISKRISN | REKLNLKKKT | DLSIFRTPIS | ||||
| KTNKRTKPII | AVAQSSLTFI | KPLKTDIPRH | PMPFAAKNMF | YDERWKEKQE | ||||
| QGFTWWLNFI | LTPDDFTVKT | NISEVNAATL | LLGIENQHKI | SVPRAPTKEE | ||||
| MSLRAYTARC | RLNRLRRAAC | RLFTSEKMVK | AIKKLEIEIE | ARRLIVRKDR | ||||
| HLWKDVGERQ | KVLNWLLSYN | PLWLRIGLET | TYGELISLED | NSDVTGLAMF | ||||
| ILNRLLWNPD | IAAEYRHPTV | PHLYRDGHEE | ALSKFTLKKL | LLLVCFLDYA | ||||
| KISRLIDHDP | CLFCKDAEFK | ASKEILLAFS | RDFLSGEGDL | SRHLGLLGLP | ||||
| VNHVQTPFDE | FDFAVTNLAV | DLQCGVRLVR | TMELLTQNWD | LSKKLRIPAI | ||||
| SRLQKMHNVD | IVLQVLKSRG | IELSDEHGNT | ILSKDIVDRH | REKTLRLLWK | ||||
| IAFAFQVDIS | LNLDQLKEEI | AFLKHTKSIK | KTISLLSCHS | DDLINKKKGK | ||||
| RDSGSFEQYS | ENIKLLMDWV | NAVCAFYNKK | VENFTVSFSD | GRVLCYLIHH | ||||
| YHPCYVPFDA | ICQRTTQTVE | CTQTGSVVLN | SSSESDDSSL | DMSLKAFDHE | ||||
| NTSELYKELL | ENEKKNFHLV | RSAVRDLGGI | PAMINHSDMS | NTIPDEKVVI | ||||
| TYLSFLCARL | LDLRKEIRAA | RLIQTTWRKY | KLKTDLKRHQ | EREKAARIIQ | ||||
| LAVINFLAKQ | RLRKRVNAAL | VIQKYWRRVL | AQRKLLMLKK | EKLEKVQNKA | ||||
| ASLIQGYWRR | YSTRQRFLKL | KYYSIILQSR | IRMIIAVTSY | KRYLWATVTI | ||||
| QRHWRAYLRR | KQDQQRYEML | KSSTLIIQSM | FRKWKQRKMQ | SQVKATVILQ | ||||
| RAFREWHLRK | QAKEENSAII | IQSWYRMHKE | LRKYIYIRSC | VVIIQKRFRC | ||||
| FQAQKLYKRR | KESILTIQKY | YKAYLKGKIE | RTNYLQKRAA | AIQLQAAFRR | ||||
| LKAHNLCRQI | RAACVIQSYW | RMRQDRVRFL | NLKKTIIKFQ | AHVRKHQQRQ | ||||
| KYKKMKKAAV | IIQTHFRAYI | FAMKVLASYQ | KTRSAVIVLQ | SAYRGMQARK | ||||
| MYIHILTSVI | KIQSYYRAYV | SKKEFLSLKN | ATIKLQSTVK | MKQTRKQYLH | ||||
| LRAAALFIQQ | CYRSKKIAAQ | KREEYMQMRE | SCIKLQAFVR | GYLVRKQMRL | ||||
| QRKAVISLQS | YFRMRKARQY | YLKMYKAIIV | IQNYYHAYKA | QVNQRKNFLQ | ||||
| VKKAATCLQA | AYRGYKVRQL | IKQQSIAALK | IQSAFRGYNK | RVKYQSVLQS | ||||
| IIKIQRWYRA | YKTLHDTRTH | FLKTKAAVIS | LQSAYRGWKV | RKQIRREHQA | ||||
| ALKIQSAFRM | AKAQKQFRLF | KTAALVIQQN | FRAWTAGRKQ | CMEYIELRHA | ||||
| VLVLQSMWKG | KTLRRQLQRQ | HKCAIIIQSY | YRMHVQQKKW | KIMKKAALLI | ||||
| QKYYRAYSIG | REQNHLYLKT | KAAVVTLQSA | YRGMKVRKRI | KDCNKAAVTI | ||||
| QSKYRAYKTK | KKYATYRASA | IIIQRWYRGI | KITNHQHKEY | LNLKKTAIKI | ||||
| QSVYRGIRVR | RHIQHMHRAA | TFIKAMFKMH | QSRISYHTMR | KAAIVIQVRC | ||||
| RAYYQGKMQR | EKYLTILKAV | KVLQASFRGV | RVRRTLRKMQ | TAATLIQSNY | ||||
| RRYRQQTYFN | KLKKITKTVQ | QRYWAMKERN | IQFQRYNKLR | HSVIYIQAIF | ||||
| RGKKARRHLK | MMHIAATLIQ | RRFRTLMMRR | RFLSLKKTAI | LIQRKYRAHL | ||||
| CTKHHLQFLQ | VQNAVIKIQS | SYRRWMIRKR | MREMHRAATF | IQSTFRMHRL | ||||
| HMRYQALKQA | SVVIQQQYQA | NRAAKLQRQH | YLRQRHSAVI | LQAAFRGMKT | ||||
| RRHLKSMHSS | ATLIQSRFRS | LLVRRRFISL | KKATIFVQRK | YRATICAKHK | ||||
| LYQFLHLRKA | AITIQSSYRR | LMVKKKLQEM | QRAAVLIQAT | FRMYRTYITF | ||||
| QTWKHASILI | QQHYRTYRAA | KLQRENYIRQ | WHSAVVIQAA | YKGMKARQLL | ||||
| REKHKASIVI | QSTYRMYRQY | CFYQKLQWAT | KIIQEKYRAN | KKKQKVFQHN | ||||
| ELKKETCVQA | GFQDMNIKKQ | IQEQHQAAII | IQKHCKAFKI | RKHYLHLRAT | ||||
| VVSIQRRYRK | LTAVRTQAVI | CIQSYYRGFK | VRKDIQNMHR | AATLIQSFYR | ||||
| MHRAKVDYET | KKTAIVVIQN | YYRLYVRVKT | ERKNFLAVQK | SVRTIQAAFR | ||||
| GMKVRQKLKN | VSEEKMAAIV | NQSALCCYRS | KTQYEAVQSE | GVMIQEWYKA | ||||
| SGLACSQEAE | YHSQSRAAVT | IQKAFCRMVT | RKLETQKCAA | LRIQFFLQMA | ||||
| VYRRRFVQQK | RAAITLQHYF | RTWQTRKQFL | LYRKAAVVLQ | NHYRAFLSAK | ||||
| HQRQVYLQIR | SSVIIIQARS | KGFIQKRKFQ | EIKNSTIKIQ | AMWRRYRAKK | ||||
| YLCKVKAACK | IQAWYRCWRA | HKEYLAILKA | VKIIQGCFYT | KLERTRFLNV | ||||
| RASAIIIQRK | WRAILPAKIA | HEHFLMIKRH | RAACLIQAHY | RGYKGRQVFL | ||||
| RQKSAALIIQ | KYIRAREAGK | HERIKYIEFK | KSTVILQALV | RGWLVRKRFL | ||||
| EQRAKIRLLH | FTAAAYYHLN | AVRIQRAYKL | YLAVKNANKQ | VNSVICIQRW | ||||
| FRARLQEKRF | IQKYHSIKKI | EHEGQECLSQ | RNRAASVIQK | AVRHFLLRKK | ||||
| QEKFTSGIIK | IQALWRGYSW | RKKNDCTKIK | AIRLSLQVVN | REIREENKLY | ||||
| KRTALALHYL | LTYKHLSAIL | EALKHLEVVT | RLSPLCCENM | AQSGAISKIF | ||||
| VLIRSCNRSI | PCMEVIRYAV | QVLLNVSKYE | KTTSAVYDVE | NCIDILLELL | ||||
| QIYREKPGNK | VADKGGSIFT | KTCCLLAILL | KTTNRASDVR | SRSKVVDRIY | ||||
| SLYKLTAHKH | KMNTERILYK | QKKNSSISIP | FIPETPVRTR | IVSRLKPDWV | ||||
| LRRDNMEEIT | NPLQAIQMVM | DTLGIPY |
Задіяний у таких біологічних процесах як клітинний цикл, поділ клітини, мітоз. Білок має сайт для зв'язування з молекулою кальмодуліну. Локалізований у цитоплазмі, цитоскелеті, ядрі.
Література
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14: 2121 — 2127. 2004. PubMed DOI:10.1101/gr.2596504
- Wang J.-K., Li Y., Su B. (2008). A common SNP of MCPH1 is associated with cranial volume variation in Chinese population.. Hum. Mol. Genet. 17: 1329 — 1335. PubMed DOI:10.1093/hmg/ddn021
- Zhang J. (2003). Evolution of the human ASPM gene, a major determinant of brain size.. Genetics 165: 2063 — 2070. PubMed
Примітки
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:19048 (англ.). Процитовано 25 серпня 2017.
- UniProt, Q8IZT6 (англ.). Процитовано 25 серпня 2017.
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