HMGB1

HMGB1 (англ. High mobility group box 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 13-ї хромосоми. [3] Довжина поліпептидного ланцюга білка становить 215 амінокислот, а молекулярна маса — 24 894[4].

HMGB1
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 2LY4, 2RTU, 2YRQ
Ідентифікатори
Символи	HMGB1, HMG1, HMG3, SBP-1, HMG-1, high mobility group box 1
Зовнішні ІД	OMIM: 163905 HomoloGene: 110676 GeneCards: HMGB1
Онтологія гена Молекулярна функція • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • bubble DNA binding • DNA polymerase binding • C-X-C chemokine binding • transcription factor binding • phosphatidylserine binding • lipopolysaccharide binding • lyase activity • single-stranded DNA binding • damaged DNA binding • GO:0001948 protein binding • DNA binding, bending • supercoiled DNA binding • DNA binding • four-way junction DNA binding • RAGE receptor binding • chemoattractant activity • RNA binding • double-stranded DNA binding • double-stranded RNA binding • single-stranded RNA binding • cytokine activity • calcium-dependent protein kinase regulator activity • protein kinase activator activity • GO:0001105 transcription coactivator activity • integrin binding Клітинна компонента • цитоплазма • Ендосома • мембрана • transcription repressor complex • extracellular region • клітинне ядро • cell surface • клітинна мембрана • Нуклеоплазма • хромосома • condensed chromosome • endoplasmic reticulum-Golgi intermediate compartment • secretory granule lumen • ficolin-1-rich granule lumen • extracellular space • early endosome • neuron projection • alphav-beta3 integrin-HMGB1 complex Біологічний процес • T-helper 1 cell activation • apoptotic DNA fragmentation • adaptive immune response • regulation of transcription by RNA polymerase II • positive regulation of DNA ligation • positive regulation of JNK cascade • cellular response to DNA damage stimulus • apoptotic cell clearance • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of toll-like receptor 9 signaling pathway • negative regulation of RNA polymerase II transcription preinitiation complex assembly • positive regulation of dendritic cell differentiation • positive regulation of DNA binding • neuron projection development • negative regulation of blood vessel endothelial cell migration • positive regulation of interleukin-12 production • positive regulation of monocyte chemotaxis • activation of innate immune response • DNA ligation involved in DNA repair • Вроджений імунітет • inflammatory response • Репарація ДНК • positive regulation of MAPK cascade • positive regulation of activated T cell proliferation • DNA geometric change • DNA recombination • inflammatory response to antigenic stimulus • positive regulation of interleukin-10 production • immune system process • negative regulation of transcription by RNA polymerase II • regulation of restriction endodeoxyribonuclease activity • хемотаксис • positive regulation of mismatch repair • negative regulation of CD4-positive, alpha-beta T cell differentiation • positive regulation of cytosolic calcium ion concentration • T-helper 1 cell differentiation • dendritic cell chemotaxis • Автофагія • neutrophil clearance • V(D)J-рекомбінація • positive regulation of apoptotic process • DNA topological change • positive chemotaxis • toll-like receptor signaling pathway • neutrophil degranulation • розвиток ока • myeloid dendritic cell activation • positive regulation of protein phosphorylation • endothelial cell proliferation • plasmacytoid dendritic cell activation • macrophage activation involved in immune response • regulation of tolerance induction • regulation of T cell mediated immune response to tumor cell • base-excision repair • regulation of autophagy • lung development • chromatin assembly • activation of protein kinase activity • positive regulation of interferon-alpha production • positive regulation of interferon-beta production • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • positive regulation of toll-like receptor 2 signaling pathway • positive regulation of toll-like receptor 4 signaling pathway • endothelial cell chemotaxis • positive regulation of innate immune response • positive regulation of myeloid cell differentiation • positive regulation of glycogen catabolic process • regulation of protein kinase activity • positive regulation of transcription by RNA polymerase II • response to glucocorticoid • positive regulation of ERK1 and ERK2 cascade • positive regulation of wound healing • positive regulation of NIK/NF-kappaB signaling • positive regulation of sprouting angiogenesis • negative regulation of apoptotic cell clearance • regulation of nucleotide-excision repair • regulation of signaling receptor activity • Ремоделювання хроматину • positive regulation of autophagy • developmental process • positive regulation of blood vessel endothelial cell migration • cell chemotaxis • cellular response to lipopolysaccharide • positive regulation of vascular endothelial cell proliferation • negative regulation of interferon-gamma production • positive regulation of monocyte chemotactic protein-1 production • cellular response to interleukin-7 Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	3146	321622
Ensembl	ENSG00000189403	ENSDARG00000099175
UniProt	P09429	Q6NX86
RefSeq (мРНК)	NM_001313892 NM_001313893 NM_002128	NM_199555
RefSeq (білок)	NP_001300821 NP_001300822 NP_002119 NP_001350590 NP_001357268 NP_001357269 NP_001357270 NP_001300821.1 NP_001300822.1 NP_002119.1	NP_955849
Локус (UCSC)	Хр. 13: 30.46 – 30.62 Mb	н/д
PubMed search	[1]	[2]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Задіяний у таких біологічних процесах як адаптивний імунітет, імунітет, вроджений імунітет, запальна відповідь, пошкодження ДНК, репарація ДНК, хемотаксис, рекомбінація ДНК, автофагія. Білок має сайт для зв'язування з ДНК. Локалізований у клітинній мембрані, цитоплазмі, ядрі, мембрані, хромосомах, ендосомах. Також секретований назовні.