PRKN

PRKN (англ. Parkin RBR E3 ubiquitin protein ligase) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми.[4] Довжина поліпептидного ланцюга білка становить 465 амінокислот, а молекулярна маса — 51 641[5].

PRKN
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 1IYF, 2JMO, 4I1F, 4I1H, 4BM9, 5C1Z, 5C23, 5C9V
Ідентифікатори
Символи	PRKN, parkin RBR E3 ubiquitin protein ligase, AR-JP, LPRS2, PDJ, PARK2, Parkin
Зовнішні ІД	OMIM: 602544 MGI: 1355296 HomoloGene: 3355 GeneCards: PRKN
Пов'язані генетичні захворювання
рак підшлункової залози, autosomal recessive juvenile Parkinson disease 2[1]
Онтологія гена Молекулярна функція • phospholipase binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • SH3 domain binding • histone deacetylase binding • tubulin binding • cullin family protein binding • PDZ domain binding • heat shock protein binding • зв'язування з іоном металу • Hsp70 protein binding • kinase binding • enzyme binding • beta-catenin binding • zinc ion binding • GO:0001948 protein binding • ubiquitin conjugating enzyme binding • protein kinase binding • chaperone binding • GO:0000975 transcription cis-regulatory region binding • ubiquitin-protein transferase activity • F-box domain binding • ubiquitin binding • identical protein binding • actin binding • ubiquitin-specific protease binding • G protein-coupled receptor binding • ubiquitin protein ligase binding • transferase activity • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0032403 protein-containing complex binding Клітинна компонента • цитоплазма • гіалоплазма • мітохондрія • perinuclear region of cytoplasm • клітинне ядро • Тільця Леві • SCF ubiquitin ligase complex • aggresome • ендоплазматичний ретикулум • комплекс Ґольджі • Parkin-FBXW7-Cul1 ubiquitin ligase complex • ubiquitin ligase complex • LUBAC complex • presynapse • neuron projection • mitochondrion-derived vesicle • nuclear speck • protein-containing complex Біологічний процес • negative regulation of neuron apoptotic process • protein K29-linked ubiquitination • negative regulation of insulin secretion • ERAD pathway • positive regulation of mitochondrial fission • positive regulation of mitophagy in response to mitochondrial depolarization • positive regulation of protein catabolic process • synaptic transmission, glutamatergic • positive regulation of tumor necrosis factor-mediated signaling pathway • neuron cellular homeostasis • regulation of protein ubiquitination • cellular response to toxic substance • modulation of chemical synaptic transmission • regulation of synaptic vesicle transport • навчення • protein monoubiquitination • cellular protein catabolic process • synaptic transmission, dopaminergic • positive regulation of neurotransmitter uptake • regulation of glucose metabolic process • protein K6-linked ubiquitination • negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator • negative regulation of spontaneous neurotransmitter secretion • negative regulation by host of viral genome replication • positive regulation of DNA binding • macroautophagy • negative regulation of canonical Wnt signaling pathway • cellular response to unfolded protein • aggresome assembly • proteasome-mediated ubiquitin-dependent protein catabolic process • regulation of dopamine secretion • zinc ion homeostasis • free ubiquitin chain polymerization • regulation of transcription, DNA-templated • locomotory behavior • norepinephrine metabolic process • negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway • adult locomotory behavior • protein metabolic process • negative regulation of cell death • response to oxidative stress • protein K27-linked ubiquitination • negative regulation of gene expression • transcription, DNA-templated • response to endoplasmic reticulum stress • protein K11-linked ubiquitination • central nervous system development • negative regulation of oxidative stress-induced cell death • positive regulation of mitochondrial fusion • protein localization to mitochondrion • proteasomal protein catabolic process • cellular response to manganese ion • negative regulation of mitochondrial fusion • protein autoubiquitination • negative regulation of neuron death • negative regulation of protein phosphorylation • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • negative regulation of primary amine oxidase activity • startle response • mitochondrial fission • regulation of mitochondrion organization • regulation of canonical Wnt signaling pathway • negative regulation of release of cytochrome c from mitochondria • protein stabilization • mitochondrion organization • protein polyubiquitination • negative regulation of transcription by RNA polymerase II • regulation of reactive oxygen species metabolic process • regulation of neurotransmitter secretion • positive regulation of protein linear polyubiquitination • protein K48-linked ubiquitination • dopamine uptake involved in synaptic transmission • regulation of autophagy • regulation of protein targeting to mitochondrion • protein destabilization • negative regulation of glucokinase activity • positive regulation of proteasomal protein catabolic process • cellular protein metabolic process • protein K63-linked ubiquitination • cellular response to dopamine • regulation of lipid transport • negative regulation of actin filament bundle assembly • regulation of dopamine metabolic process • regulation of mitochondrial membrane potential • Автофагія • negative regulation of JNK cascade • dopamine metabolic process • positive regulation of gene expression • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of dendrite extension • negative regulation of reactive oxygen species metabolic process • positive regulation of transcription by RNA polymerase II • mitophagy • Убіквітин-залежний протеоліз • parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • protein deubiquitination • regulation of protein stability • positive regulation of protein binding • mitochondrion to lysosome transport • regulation of cellular response to oxidative stress • negative regulation of exosomal secretion • positive regulation of retrograde transport, endosome to Golgi • negative regulation of intralumenal vesicle formation • positive regulation of protein localization to membrane • autophagy of mitochondrion • negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • positive regulation of autophagy of mitochondrion • ubiquitin-dependent protein catabolic process • regulation of apoptotic process Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	5071	50873
Ensembl	ENSG00000185345	ENSMUSG00000023826
UniProt	O60260	Q9WVS6
RefSeq (мРНК)	NM_004562 NM_013987 NM_013988	NM_016694 NM_001317726
RefSeq (білок)	NP_004553 NP_054642 NP_054643	NP_001304655 NP_057903
Локус (UCSC)	Хр. 6: 161.35 – 162.73 Mb	Хр. 17: 11.06 – 12.28 Mb
PubMed search	[2]	[3]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Кодований геном білок за функціями належить до трансфераз, фосфопротеїнів. Задіяний у таких біологічних процесах, як транскрипція, регуляція транскрипції, убіквітинування білків, автофагія, альтернативний сплайсинг. Білок має сайт для зв'язування з іонами металів, іоном цинку. Локалізований у цитоплазмі, ядрі, мітохондрії, ендоплазматичному ретикулумі.