SMAD3

SMAD3 (англ. SMAD family member 3) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 15-ї хромосоми.[4] Довжина поліпептидного ланцюга білка становить 425 амінокислот, а молекулярна маса — 48 081[5].

SMAD3
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 2LB2, 1MHD, 1MJS, 1MK2, 1OZJ, 1U7F, 2LAJ, 5OD6, 5ODG
Ідентифікатори
Символи	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, SMAD family member 3
Зовнішні ІД	OMIM: 603109 MGI: 1201674 HomoloGene: 55937 GeneCards: SMAD3
Пов'язані генетичні захворювання
inflammatory bowel diseases, Хвороба Крона, бронхіальна астма, ішемічна хвороба серця, колоректальний рак, aneurysm-osteoarthritis syndrome[1]
Онтологія гена Молекулярна функція • phosphatase binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • R-SMAD binding • co-SMAD binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • transcription factor binding • зв'язування з іоном металу • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • enzyme binding • transforming growth factor beta receptor binding • protein homodimerization activity • collagen binding • zinc ion binding • chromatin binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • GO:0001948 protein binding • double-stranded DNA binding • protein kinase binding • sequence-specific DNA binding • DNA binding • bHLH transcription factor binding • ubiquitin binding • identical protein binding • protein heterodimerization activity • chromatin DNA binding • ubiquitin protein ligase binding • beta-catenin binding • GO:0000983 RNA polymerase II general transcription initiation factor activity • DEAD/H-box RNA helicase binding • mineralocorticoid receptor binding • glucocorticoid receptor binding • primary miRNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • SMAD binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001104 transcription coregulator activity Клітинна компонента • цитоплазма • клітинне ядро • heteromeric SMAD protein complex • SMAD protein complex • transcription regulator complex • receptor complex • клітинна мембрана • внутрішньоклітинний • Нуклеоплазма • nuclear inner membrane • гіалоплазма • protein-containing complex Біологічний процес • somitogenesis • skeletal system development • ureteric bud development • endoderm development • regulation of transforming growth factor beta2 production • embryonic pattern specification • regulation of transcription by RNA polymerase II • negative regulation of osteoblast differentiation • heart looping • positive regulation of chondrocyte differentiation • positive regulation of alkaline phosphatase activity • positive regulation of interleukin-1 beta production • pericardium development • regulation of binding • negative regulation of wound healing • activation of cysteine-type endopeptidase activity involved in apoptotic process • transforming growth factor beta receptor signaling pathway • negative regulation of inflammatory response • positive regulation of positive chemotaxis • negative regulation of cell population proliferation • negative regulation of fat cell differentiation • cell-cell junction organization • regulation of transcription, DNA-templated • extrinsic apoptotic signaling pathway • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • signal transduction involved in regulation of gene expression • in utero embryonic development • negative regulation of transforming growth factor beta receptor signaling pathway • nodal signaling pathway • positive regulation of transcription, DNA-templated • negative regulation of cell growth • regulation of immune response • positive regulation of transforming growth factor beta3 production • T cell activation • activin receptor signaling pathway • regulation of striated muscle tissue development • embryonic foregut morphogenesis • positive regulation of bone mineralization • Загоєння ран • negative regulation of apoptotic process • positive regulation of extracellular matrix assembly • negative regulation of transcription by RNA polymerase II • positive regulation of epithelial to mesenchymal transition • mitigation of host defenses by virus • thyroid gland development • developmental growth • lens fiber cell differentiation • Гаструляція • Імунна відповідь • osteoblast differentiation • primary miRNA processing • negative regulation of osteoblast proliferation • osteoblast development • embryonic cranial skeleton morphogenesis • transdifferentiation • paraxial mesoderm morphogenesis • response to hypoxia • positive regulation of cell migration • mesoderm formation • regulation of transforming growth factor beta receptor signaling pathway • positive regulation of gene expression • immune system development • positive regulation of focal adhesion assembly • liver development • regulation of epithelial cell proliferation • positive regulation of stress fiber assembly • positive regulation of transcription by RNA polymerase II • negative regulation of mitotic cell cycle • negative regulation of cytosolic calcium ion concentration • canonical Wnt signaling pathway • protein stabilization • transcription, DNA-templated • negative regulation of protein catabolic process • protein deubiquitination • positive regulation of nitric oxide biosynthetic process • negative regulation of lung blood pressure • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of cardiac muscle hypertrophy in response to stress • cellular response to transforming growth factor beta stimulus • cellular response to cytokine stimulus • positive regulation of protein import into nucleus • positive regulation of DNA-binding transcription factor activity • SMAD protein signal transduction • positive regulation of canonical Wnt signaling pathway • SMAD protein complex assembly • adrenal gland development Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	4088	17127
Ensembl	ENSG00000166949	ENSMUSG00000032402
UniProt	P84022	Q8BUN5
RefSeq (мРНК)	NM_001145102 NM_001145103 NM_001145104 NM_005902	NM_016769
RefSeq (білок)	NP_001138574 NP_001138575 NP_001138576 NP_005893	NP_058049
Локус (UCSC)	Хр. 15: 67.06 – 67.2 Mb	Хр. 9: 63.65 – 63.76 Mb
PubMed search	[2]	[3]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у таких біологічних процесах, як транскрипція, регуляція транскрипції, ацетилювання, альтернативний сплайсинг. Білок має сайт для зв'язування з іонами металів, іоном цинку, ДНК. Локалізований у цитоплазмі, ядрі.