Src (ген)

Src (англ. SRC proto-oncogene, non-receptor tyrosine kinase) – білок, який кодується геном SRC, розташованим у людини на довгому плечі 20-ї хромосоми.[4] Довжина поліпептидного ланцюга білка становить 536 амінокислот, а молекулярна маса — 59 835[5].

Src
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 1A07, 1A08, 1A09, 1A1A, 1A1B, 1A1C, 1A1E, 1FMK, 1HCS, 1HCT, 1KSW, 1O41, 1O42, 1O43, 1O44, 1O45, 1O46, 1O47, 1O48, 1O49, 1O4A, 1O4B, 1O4C, 1O4D, 1O4E, 1O4F, 1O4G, 1O4H, 1O4I, 1O4J, 1O4K, 1O4L, 1O4M, 1O4N, 1O4O, 1O4P, 1O4Q, 1O4R, 1SHD, 1Y57, 1YI6, 1YOJ, 1YOL, 1YOM, 2BDF, 2H8H, 3VRO, 3ZMP, 3ZMQ, 4F59, 4F5A, 4F5B, 4HXJ, 4K11, 4MXO, 4MXX, 4MXY, 4MXZ
Ідентифікатори
Символи	SRC, ASV, SRC1, c-p60-Src, SRC proto-oncogene, non-receptor tyrosine kinase, THC6
Зовнішні ІД	OMIM: 190090 MGI: 98397 HomoloGene: 21120 GeneCards: SRC
шифр КФ	2.7.10.2
Реагує на сполуку
Бозутиніб, Дазатиніб, saracatinib, SU6656[1]
Онтологія гена Молекулярна функція • transmembrane transporter binding • protein domain specific binding • GO:0032403 protein-containing complex binding • SH2 domain binding • kinase activity • signaling receptor binding • estrogen receptor binding • ATP binding • protein kinase activity • insulin receptor binding • non-membrane spanning protein tyrosine kinase activity • kinase binding • heme binding • enzyme binding • transferase activity • ephrin receptor binding • scaffold protein binding • integrin binding • GO:0001948 protein binding • protein kinase binding • cell adhesion molecule binding • protein kinase C binding • hormone receptor binding • nucleotide binding • growth factor receptor binding • phosphoprotein binding • protein tyrosine kinase activity • protein C-terminus binding • ubiquitin protein ligase binding • cadherin binding • connexin binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Клітинна компонента • цитоплазма • гіалоплазма • мембрана • extrinsic component of cytoplasmic side of plasma membrane • ruffle membrane • мітохондрія • perinuclear region of cytoplasm • caveola • neuron projection • Цитоскелет • клітинне ядро • Лізосома • Екзосома • late endosome • клітинна мембрана • Мікрофіламенти • GO:0097483, GO:0097481 Постсинаптичне ущільнення • мітохондріальна внутрішня мембрана • podosome • Нуклеоплазма • glutamatergic synapse • postsynaptic specialization, intracellular component Біологічний процес • response to mineralocorticoid • negative regulation of telomere maintenance via telomerase • response to interleukin-1 • positive regulation of MAP kinase activity • positive regulation of canonical Wnt signaling pathway • negative regulation of telomerase activity • cellular response to progesterone stimulus • regulation of intracellular estrogen receptor signaling pathway • stress fiber assembly • positive regulation of protein serine/threonine kinase activity • platelet activation • positive regulation of smooth muscle cell migration • protein phosphorylation • regulation of vascular permeability • vascular endothelial growth factor receptor signaling pathway • positive regulation of ERK1 and ERK2 cascade • regulation of podosome assembly • клітинний цикл • substrate adhesion-dependent cell spreading • osteoclast development • проліферація • transforming growth factor beta receptor signaling pathway • cellular response to hypoxia • cellular response to transforming growth factor beta stimulus • negative regulation of protein homooligomerization • positive regulation of protein kinase B signaling • positive regulation of lamellipodium morphogenesis • epidermal growth factor receptor signaling pathway • branching involved in mammary gland duct morphogenesis • Fc-gamma receptor signaling pathway involved in phagocytosis • negative regulation of intrinsic apoptotic signaling pathway • negative regulation of extrinsic apoptotic signaling pathway • response to mechanical stimulus • response to virus • positive regulation of epithelial cell migration • signal complex assembly • stimulatory C-type lectin receptor signaling pathway • positive regulation of platelet-derived growth factor receptor signaling pathway • Оогенез • positive regulation of transcription, DNA-templated • regulation of epithelial cell migration • response to nutrient levels • positive regulation of DNA biosynthetic process • cellular response to insulin stimulus • protein autophosphorylation • GO:0022415 viral process • negative regulation of focal adhesion assembly • response to acidic pH • response to fatty acid • regulation of cell projection assembly • фосфорилювання • immune system process • negative regulation of mitochondrial depolarization • positive regulation of integrin activation • negative regulation of apoptotic process • cellular response to platelet-derived growth factor stimulus • positive regulation of podosome assembly • positive regulation of glucose metabolic process • Цитопемпсис • cellular response to fluid shear stress • response to electrical stimulus • positive regulation of protein transport • uterus development • protein destabilization • regulation of cell-cell adhesion • peptidyl-tyrosine autophosphorylation • integrin-mediated signaling pathway • positive regulation of insulin receptor signaling pathway • progesterone receptor signaling pathway • negative regulation of transcription, DNA-templated • adherens junction organization • negative regulation of anoikis • response to hydrogen peroxide • leukocyte migration • activation of protein kinase B activity • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0007243 intracellular signal transduction • regulation of early endosome to late endosome transport • ephrin receptor signaling pathway • T cell costimulation • GO:0010740 positive regulation of intracellular signal transduction • regulation of caveolin-mediated endocytosis • regulation of cell cycle • positive regulation of phosphatidylinositol 3-kinase activity • cellular response to reactive oxygen species • cellular response to peptide hormone stimulus • positive regulation of gene expression • cellular response to fatty acid • regulation of cell population proliferation • angiotensin-activated signaling pathway involved in heart process • peptidyl-serine phosphorylation • positive regulation of protein autophosphorylation • positive regulation of cyclin-dependent protein serine/threonine kinase activity • positive regulation of apoptotic process • forebrain development • regulation of protein binding • cellular response to lipopolysaccharide • regulation of bone resorption • cell migration • Сигнальна трансдукція • positive regulation of cell adhesion • адгезія клітин • positive regulation of protein processing • Вроджений імунітет • positive regulation of peptidyl-tyrosine phosphorylation • neurotrophin TRK receptor signaling pathway • positive regulation of small GTPase mediated signal transduction • bone resorption • central nervous system development • positive regulation of protein localization to nucleus • platelet-derived growth factor receptor signaling pathway • ERBB2 signaling pathway • intracellular estrogen receptor signaling pathway • axon guidance • macroautophagy • peptidyl-tyrosine phosphorylation • entry of bacterium into host cell • cell-cell adhesion • primary ovarian follicle growth • positive regulation of ovarian follicle development • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of phosphatidylinositol 3-kinase signaling • Диференціація клітин • phosphatidylinositol phosphate biosynthetic process • regulation of postsynaptic neurotransmitter receptor activity • positive regulation of non-membrane spanning protein tyrosine kinase activity • G protein-coupled receptor signaling pathway • cellular response to hydrogen peroxide • positive regulation of platelet-derived growth factor receptor-beta signaling pathway • odontogenesis Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	6714	20779
Ensembl	ENSG00000197122	ENSMUSG00000027646
UniProt	P12931	P05480
RefSeq (мРНК)	NM_005417 NM_198291	NM_001025395 NM_009271
RefSeq (білок)	NP_005408 NP_938033	NP_001020566 NP_033297
Локус (UCSC)	Хр. 20: 37.34 – 37.41 Mb	Хр. 2: 157.42 – 157.47 Mb
PubMed search	[2]	[3]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Кодований геном білок за функціями належить до тирозинових протеїнкіназ родини Src-протеїнкіназ.

Задіяний у таких біологічних процесах, як клітинна адгезія, імунітет, взаємодія хазяїн-вірус, клітинний цикл, альтернативний сплайсинг. Білок є ліпопротеїном, має сайт для зв'язування з АТФ. Локалізований у клітинній мембрані, цитоплазмі, цитоскелеті, ядрі, внутрішній мембрані мітохондрії.