ABL1

ABL1 (англ. ABL proto-oncogene 1, non-receptor tyrosine kinase) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 9-ї хромосоми.[4] Довжина поліпептидного ланцюга білка становить 1 130 амінокислот, а молекулярна маса — 122 873[5].

ABL1
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 1AB2, 1AWO, 1BBZ, 1JU5, 1OPL, 1ZZP, 2ABL, 2E2B, 2FO0, 2G1T, 2G2F, 2G2H, 2G2I, 2GQG, 2HIW, 2HYY, 2HZ0, 2HZ4, 2HZI, 2V7A, 3CS9, 3EG0, 3EG1, 3EG2, 3EG3, 3EGU, 3K2M, 3QRI, 3QRJ, 3QRK, 3T04, 3UE4, 3UYO, 3PYY, 4J9B, 4J9C, 4J9D, 4J9E, 4J9F, 4J9G, 4J9H, 4J9I, 4JJB, 4JJC, 4JJD, 4TWP, 4WA9, 4XEY, 4YC8, 5DC9, 5DC4, 5DC0, 2O88, 5HU9
Ідентифікатори
Символи	ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase, ABL, JTK7, bcr/abl, c-ABL, c-p150, v-abl, CHDSKM, BCR-ABL, Genes, abl
Зовнішні ІД	OMIM: 189980 MGI: 87859 HomoloGene: 3783 GeneCards: ABL1
шифр КФ	2.7.10.2
Реагує на сполуку
bafetinib, Бозутиніб, Дазатиніб, Іматиніб, нілотиніб, ponatinib, saracatinib[1]
Онтологія гена Молекулярна функція • actin monomer binding • protein domain specific binding • SH3 domain binding • kinase activity • protein C-terminus binding • signaling receptor binding • ATP binding • protein kinase activity • nicotinate-nucleotide adenylyltransferase activity • non-membrane spanning protein tyrosine kinase activity • зв'язування з іоном металу • proline-rich region binding • magnesium ion binding • transferase activity • actin filament binding • GO:0001948 protein binding • syntaxin binding • protein kinase C binding • DNA binding • nucleotide binding • manganese ion binding • mitogen-activated protein kinase binding • protein tyrosine kinase activity • four-way junction DNA binding • bubble DNA binding • phosphotyrosine residue binding • GO:0001105 transcription coactivator activity • neuropilin binding • SH2 domain binding • ephrin receptor binding • supercoiled DNA binding • sequence-specific double-stranded DNA binding Клітинна компонента • цитоплазма • гіалоплазма • Ядерна мембрана • мембрана • extrinsic component of cytoplasmic side of plasma membrane • мітохондрія • actin cytoskeleton • perinuclear region of cytoplasm • Цитоскелет • клітинне ядро • Ядерце • Нуклеоплазма • cell leading edge • Ядерні тільця • Дендрит (нейробіологія) • protein-containing complex • neuronal cell body • postsynapse Біологічний процес • positive regulation of protein phosphorylation • B-1 B cell homeostasis • regulation of axon extension • neuromuscular process controlling balance • positive regulation of muscle cell differentiation • cellular response to DNA damage stimulus • protein phosphorylation • regulation of cell adhesion • cellular protein modification process • regulation of microtubule polymerization • DNA damage induced protein phosphorylation • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of ERK1 and ERK2 cascade • substrate adhesion-dependent cell spreading • platelet-derived growth factor receptor-beta signaling pathway • positive regulation of actin filament binding • B cell receptor signaling pathway • Апоптоз • negative regulation of endothelial cell apoptotic process • cerebellum morphogenesis • regulation of actin cytoskeleton reorganization • regulation of transcription, DNA-templated • epidermal growth factor receptor signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • establishment of protein localization • thymus development • negative regulation of phospholipase C activity • positive regulation of mitotic cell cycle • actin filament branching • spleen development • response to oxidative stress • Фагоцитоз • positive regulation of peptidyl-tyrosine phosphorylation • regulation of response to DNA damage stimulus • mitochondrial depolarization • positive regulation of Wnt signaling pathway, planar cell polarity pathway • platelet-derived growth factor receptor signaling pathway • regulation of endocytosis • activation of protein kinase C activity • regulation of actin cytoskeleton organization • фосфорилювання • signal transduction in response to DNA damage • positive regulation of oxidoreductase activity • positive regulation of release of sequestered calcium ion into cytosol • negative regulation of I-kappaB kinase/NF-kappaB signaling • regulation of cell motility • positive regulation of microtubule binding • Адгезія клітин • regulation of autophagy • peptidyl-tyrosine autophosphorylation • alpha-beta T cell differentiation • regulation of cellular senescence • negative regulation of protein serine/threonine kinase activity • actin cytoskeleton organization • negative regulation of cellular senescence • positive regulation of osteoblast proliferation • GO:0007067 мітоз • activated T cell proliferation • Ендоцитоз • negative regulation of cell-cell adhesion • B cell proliferation involved in immune response • cellular response to dopamine • positive regulation of cytosolic calcium ion concentration • positive regulation of neuron death • regulation of cell cycle • negative regulation of BMP signaling pathway • Автофагія • B cell proliferation • negative regulation of ubiquitin-protein transferase activity • microspike assembly • positive regulation of apoptotic process • regulation of extracellular matrix organization • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of ERK1 and ERK2 cascade • transitional one stage B cell differentiation • mismatch repair • Bergmann glial cell differentiation • peptidyl-tyrosine phosphorylation • collateral sprouting • cellular response to lipopolysaccharide • negative regulation of mitotic cell cycle • cellular response to hydrogen peroxide • Репарація ДНК • Вроджений імунітет • neural tube closure • post-embryonic development • neuron differentiation • cellular response to oxidative stress • regulation of cell population proliferation • protein autophosphorylation • neuroepithelial cell differentiation • integrin-mediated signaling pathway • positive regulation of endothelial cell migration • Диференціація клітин • regulation of Cdc42 protein signal transduction • neuropilin signaling pathway • endothelial cell migration • regulation of T cell differentiation • positive regulation of transcription by RNA polymerase II • T cell receptor signaling pathway • positive regulation of stress fiber assembly • positive regulation of focal adhesion assembly • DNA conformation change • positive regulation of cell migration involved in sprouting angiogenesis • positive regulation of substrate adhesion-dependent cell spreading • negative regulation of long-term synaptic potentiation • regulation of hematopoietic stem cell differentiation • regulation of modification of synaptic structure • positive regulation of blood vessel branching • positive regulation of actin cytoskeleton reorganization Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	25	11350
Ensembl	ENSG00000097007	ENSMUSG00000026842
UniProt	P00519	P00520
RefSeq (мРНК)	NM_007313 NM_005157	NM_001112703 NM_009594 NM_001283045 NM_001283046 NM_001283047
RefSeq (білок)	NP_005148 NP_009297	NP_001106174 NP_001269974 NP_001269975 NP_001269976 NP_033724
Локус (UCSC)	Хр. 9: 130.71 – 130.89 Mb	Хр. 2: 31.69 – 31.8 Mb
PubMed search	[2]	[3]
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Кодований геном білок за функціями належить до трансфераз, кіназ, тирозинових протеїнкіназ, фосфопротеїнів. Задіяний у таких біологічних процесах, як апоптоз, клітинна адгезія, пошкодження ДНК, репарація ДНК, ендоцитоз, автофагія, ацетилювання, альтернативний сплайсинг. Білок має сайт для зв'язування з АТФ, нуклеотидами, іонами металів, ДНК, іоном магнію, іоном марганцю. Локалізований у цитоплазмі, цитоскелеті, ядрі, мембрані, мітохондрії.